ID   LR2BP_RAT               Reviewed;         346 AA.
AC   Q569C2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=LRP2-binding protein;
GN   Name=Lrp2bp;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May act as an adapter that regulates LRP2 function.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with LRP2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Detected in a
CC       vesicular staining pattern close to the plasma membrane and throughout
CC       the cytoplasm. {ECO:0000250}.
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DR   EMBL; BC092575; AAH92575.1; -; mRNA.
DR   RefSeq; NP_001017443.1; NM_001017443.1.
DR   AlphaFoldDB; Q569C2; -.
DR   SMR; Q569C2; -.
DR   STRING; 10116.ENSRNOP00000041732; -.
DR   PaxDb; Q569C2; -.
DR   GeneID; 290753; -.
DR   KEGG; rno:290753; -.
DR   CTD; 55805; -.
DR   RGD; 1305896; Lrp2bp.
DR   eggNOG; KOG1550; Eukaryota.
DR   InParanoid; Q569C2; -.
DR   OrthoDB; 1039341at2759; -.
DR   PhylomeDB; Q569C2; -.
DR   PRO; PR:Q569C2; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR006597; Sel1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   Pfam; PF08238; Sel1; 5.
DR   SMART; SM00671; SEL1; 5.
DR   PROSITE; PS50005; TPR; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..346
FT                   /note="LRP2-binding protein"
FT                   /id="PRO_0000315710"
FT   REPEAT          58..91
FT                   /note="TPR"
FT   REPEAT          92..124
FT                   /note="Sel1-like 1"
FT   REPEAT          132..167
FT                   /note="Sel1-like 2"
FT   REPEAT          172..205
FT                   /note="Sel1-like 3"
FT   REPEAT          206..241
FT                   /note="Sel1-like 4"
FT   REPEAT          242..276
FT                   /note="Sel1-like 5"
FT   REPEAT          296..331
FT                   /note="Sel1-like 6"
SQ   SEQUENCE   346 AA;  39633 MW;  22B88E61ED6E7A99 CRC64;
     MKLTSEKLPK NPFSLSQYAA KQQTFFQWKK EKPDYYRHAN LVDTALQFLK ERIRKGDAMA
     YFLRGQLYFE EGWYEEALAQ FEEIQEKDHQ AIYQLGVMYY DGLGTVADAE KGVGYMKKIL
     DSSCPQTMHL KFAAAYNLGR AYFEGKGVKR SDEEAERLWL YAADNGNPKA SVKAQSILGL
     FYSMKEPKDL EKAFFWHSEA CGNGNLESQG ALGLMYLYGQ GIRQDTDAAL HCLREAAERG
     NVYAQGILVE YYYKMKFFTK CVSFSKRIAD YDEVHDIPMI AHVTDCLPEF ISKGMAMASF
     YYARCLQLGL GITKDEASAK HYYSKACRLN PTLADELHSL LIHQRI