LR37B_HUMAN
ID LR37B_HUMAN Reviewed; 947 AA.
AC Q96QE4; Q17RC9; Q5YKG6;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Leucine-rich repeat-containing protein 37B;
DE AltName: Full=C66 SLIT-like testicular protein;
DE Flags: Precursor;
GN Name=LRRC37B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=10843809; DOI=10.1006/geno.2000.6179;
RA Jenne D.E., Tinschert S., Stegmann E., Reimann H., Nuernberg P., Horn D.,
RA Naumann I., Buske A., Thiel G.;
RT "A common set of at least 11 functional genes is lost in the majority of
RT NF1 patients with gross deletions.";
RL Genomics 66:93-97(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RA Wolkowicz M.J., Shetty J., Herr J.C.;
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96QE4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96QE4-2; Sequence=VSP_054513;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAR28082.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AJ314647; CAC44536.1; -; mRNA.
DR EMBL; AY386261; AAR28082.1; ALT_INIT; mRNA.
DR EMBL; AC090616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC117373; AAI17374.1; -; mRNA.
DR EMBL; BC143581; AAI43582.1; -; mRNA.
DR CCDS; CCDS32609.1; -. [Q96QE4-1]
DR RefSeq; NP_443120.2; NM_052888.2. [Q96QE4-1]
DR AlphaFoldDB; Q96QE4; -.
DR SMR; Q96QE4; -.
DR BioGRID; 125332; 33.
DR IntAct; Q96QE4; 1.
DR MINT; Q96QE4; -.
DR STRING; 9606.ENSP00000340519; -.
DR GlyGen; Q96QE4; 2 sites.
DR iPTMnet; Q96QE4; -.
DR PhosphoSitePlus; Q96QE4; -.
DR BioMuta; LRRC37B; -.
DR DMDM; 296439308; -.
DR jPOST; Q96QE4; -.
DR MassIVE; Q96QE4; -.
DR PaxDb; Q96QE4; -.
DR PeptideAtlas; Q96QE4; -.
DR PRIDE; Q96QE4; -.
DR ProteomicsDB; 61147; -.
DR ProteomicsDB; 77864; -. [Q96QE4-1]
DR Antibodypedia; 2696; 77 antibodies from 14 providers.
DR DNASU; 114659; -.
DR Ensembl; ENST00000341671.11; ENSP00000340519.7; ENSG00000185158.12. [Q96QE4-1]
DR Ensembl; ENST00000394713.7; ENSP00000378202.4; ENSG00000185158.12. [Q96QE4-1]
DR GeneID; 114659; -.
DR KEGG; hsa:114659; -.
DR UCSC; uc060dst.1; human. [Q96QE4-1]
DR CTD; 114659; -.
DR DisGeNET; 114659; -.
DR GeneCards; LRRC37B; -.
DR HGNC; HGNC:29070; LRRC37B.
DR HPA; ENSG00000185158; Tissue enhanced (bone).
DR MIM; 616558; gene.
DR neXtProt; NX_Q96QE4; -.
DR OpenTargets; ENSG00000185158; -.
DR PharmGKB; PA142671525; -.
DR VEuPathDB; HostDB:ENSG00000185158; -.
DR eggNOG; ENOG502QVVG; Eukaryota.
DR GeneTree; ENSGT00530000063282; -.
DR HOGENOM; CLU_015957_0_0_1; -.
DR InParanoid; Q96QE4; -.
DR OrthoDB; 181606at2759; -.
DR PhylomeDB; Q96QE4; -.
DR TreeFam; TF341959; -.
DR PathwayCommons; Q96QE4; -.
DR SignaLink; Q96QE4; -.
DR BioGRID-ORCS; 114659; 252 hits in 1078 CRISPR screens.
DR ChiTaRS; LRRC37B; human.
DR GenomeRNAi; 114659; -.
DR Pharos; Q96QE4; Tdark.
DR PRO; PR:Q96QE4; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q96QE4; protein.
DR Bgee; ENSG00000185158; Expressed in cerebellar cortex and 97 other tissues.
DR ExpressionAtlas; Q96QE4; baseline and differential.
DR Genevisible; Q96QE4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR015753; LRRC37.
DR InterPro; IPR032754; LRRC37_N.
DR InterPro; IPR029423; LRRC37AB_C.
DR PANTHER; PTHR23045; PTHR23045; 3.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF15779; LRRC37; 2.
DR Pfam; PF14914; LRRC37AB_C; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR PROSITE; PS51450; LRR; 4.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Glycoprotein; Leucine-rich repeat;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..947
FT /note="Leucine-rich repeat-containing protein 37B"
FT /id="PRO_0000232653"
FT TOPO_DOM 28..905
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 906..926
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 927..947
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 556..577
FT /note="LRR 1"
FT REPEAT 580..601
FT /note="LRR 2"
FT REPEAT 604..625
FT /note="LRR 3"
FT REPEAT 628..649
FT /note="LRR 4"
FT REPEAT 655..676
FT /note="LRR 5"
FT REPEAT 679..699
FT /note="LRR 6"
FT REGION 42..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 867..897
FT /evidence="ECO:0000255"
FT COMPBIAS 42..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 358
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 789
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 608..658
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_054513"
FT CONFLICT 6..24
FT /note="FWGPWPLLTWQLLSLLVKE -> ITAMAPPYVATIVFTSQG (in Ref.
FT 1; CAC44536)"
FT /evidence="ECO:0000305"
FT CONFLICT 198
FT /note="E -> G (in Ref. 2; AAR28082)"
FT /evidence="ECO:0000305"
FT CONFLICT 336
FT /note="Y -> H (in Ref. 2; AAR28082)"
FT /evidence="ECO:0000305"
FT CONFLICT 469
FT /note="K -> E (in Ref. 2; AAR28082)"
FT /evidence="ECO:0000305"
FT CONFLICT 604
FT /note="Y -> S (in Ref. 1; CAC44536)"
FT /evidence="ECO:0000305"
FT CONFLICT 621
FT /note="Q -> H (in Ref. 1; CAC44536 and 2; AAR28082)"
FT /evidence="ECO:0000305"
FT CONFLICT 641
FT /note="K -> E (in Ref. 1; CAC44536)"
FT /evidence="ECO:0000305"
FT CONFLICT 702
FT /note="T -> S (in Ref. 2; AAR28082)"
FT /evidence="ECO:0000305"
FT CONFLICT 772
FT /note="S -> G (in Ref. 2; AAR28082)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 947 AA; 105567 MW; 2C599D50C8C637AC CRC64;
MSWLRFWGPW PLLTWQLLSL LVKEAQPLVW VKDPLQLTSN PLGPPEPWSS RSSHLPWESP
HAPAPPAAPG DFDYLGPSAS SQMSALPQEP TENLAPFLKE LDSAGELPLG PEPFLAAHQD
LNDKRTPEER LPEVVPLLNR DQNQALVQLP RLKWVQTTDL DRAAGHQADE ILVPLDSKVS
RPTKFVVSPK NLKKDLAERW SLPEIVGIPH QLSKPQRQKQ TLPDDYLSMD TLYPGSLPPE
LRVNADEPPG PPEQVGLSQF HLEPKSQNPE TLEDIQSSSL QEEAPAQLLQ LPQEVEPSTQ
QEAPALPPES SMESLAQTPL NHEVTVQPPG EDQAHYNLPK FTVKPADVEV TMTSEPKNET
ESTQAQQEAP IQPPEEAEPS STALRTTDPP PEHPEVTLPP SDKGQAQHSH LTEATVQPLD
LELSITTEPT TEVKPSPTTE ETSAQPPDPG LAITPEPTTE IGHSTALEKT RAPHPDQVQT
LHRSLTEVTG PPTKLESSQD SLVQSETAPE EQKASTSTNI CELCTCGDET LSCVGLSPKQ
RLRQVPVPEP DTYNGIFTTL NFQGNYISYL DGNVWKAYSW TEKLILSENY LTELPKDSFE
GLLYLQYLDL SCNKIRYIER QTFESLPFLQ YINLGCNLIT KLSLGTFQAW HGMQFLHNLI
LNRNPLTTVE DPYLFELPAL KYLDMGTTHI TLTTLKNILT MTVELEKLIL PSHMACCLCQ
FKNSIEAVCK TVKLHCNTAC LTNSIHCPEE ASVGNPEGAF MKMLQARKQH MSTQLTIESE
APSDSSGINL SGFGGDQLEI QLTEQLRSLI PNEDVRKFMS HVIRTLKMEC SETHVQGSCA
KLMLRTGLLM KLLSEQQEAK ALNVEWDTDQ QKTNYINENM EQNEQKEQKS SELMKEVPGD
DYKNKLIFAI SVTVILIILI IIFCLIEVNS HKRASEKYKD NPSISGA
