LR74A_HUMAN
ID LR74A_HUMAN Reviewed; 488 AA.
AC Q0VAA2; Q6ZUG6; Q9Y627;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Leucine-rich repeat-containing protein 74A {ECO:0000312|HGNC:HGNC:23346};
DE AltName: Full=Leucine-rich repeat-containing protein 74 {ECO:0000312|HGNC:HGNC:23346};
GN Name=LRRC74A {ECO:0000312|HGNC:HGNC:23346};
GN Synonyms=C14orf166B {ECO:0000312|HGNC:HGNC:23346},
GN LRRC74 {ECO:0000312|HGNC:HGNC:23346};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 14-488 (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q0VAA2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q0VAA2-2; Sequence=VSP_028425, VSP_028426, VSP_028427;
CC -!- CAUTION: It is uncertain whether Met-1 or Met-27 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD44364.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAI21160.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI21161.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=EAW81265.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK125722; BAC86259.1; -; mRNA.
DR EMBL; AF111169; AAD44364.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH471061; EAW81265.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC121159; AAI21160.1; ALT_INIT; mRNA.
DR EMBL; BC121160; AAI21161.1; ALT_INIT; mRNA.
DR CCDS; CCDS9853.2; -. [Q0VAA2-1]
DR RefSeq; NP_919263.2; NM_194287.2. [Q0VAA2-1]
DR AlphaFoldDB; Q0VAA2; -.
DR SMR; Q0VAA2; -.
DR BioGRID; 126917; 3.
DR IntAct; Q0VAA2; 2.
DR MINT; Q0VAA2; -.
DR STRING; 9606.ENSP00000377369; -.
DR iPTMnet; Q0VAA2; -.
DR PhosphoSitePlus; Q0VAA2; -.
DR BioMuta; LRRC74A; -.
DR DMDM; 308153427; -.
DR MassIVE; Q0VAA2; -.
DR PaxDb; Q0VAA2; -.
DR PeptideAtlas; Q0VAA2; -.
DR PRIDE; Q0VAA2; -.
DR ProteomicsDB; 58787; -. [Q0VAA2-1]
DR Antibodypedia; 25952; 26 antibodies from 13 providers.
DR DNASU; 145497; -.
DR Ensembl; ENST00000393774.7; ENSP00000377369.3; ENSG00000100565.16. [Q0VAA2-1]
DR GeneID; 145497; -.
DR KEGG; hsa:145497; -.
DR UCSC; uc001xsx.3; human. [Q0VAA2-1]
DR CTD; 145497; -.
DR GeneCards; LRRC74A; -.
DR HGNC; HGNC:23346; LRRC74A.
DR HPA; ENSG00000100565; Tissue enriched (testis).
DR neXtProt; NX_Q0VAA2; -.
DR OpenTargets; ENSG00000100565; -.
DR PharmGKB; PA134862662; -.
DR VEuPathDB; HostDB:ENSG00000100565; -.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00940000154297; -.
DR HOGENOM; CLU_017147_3_2_1; -.
DR InParanoid; Q0VAA2; -.
DR OMA; YEAMAPK; -.
DR OrthoDB; 1463268at2759; -.
DR PhylomeDB; Q0VAA2; -.
DR TreeFam; TF329403; -.
DR PathwayCommons; Q0VAA2; -.
DR SignaLink; Q0VAA2; -.
DR BioGRID-ORCS; 145497; 15 hits in 1066 CRISPR screens.
DR ChiTaRS; LRRC74A; human.
DR GenomeRNAi; 145497; -.
DR Pharos; Q0VAA2; Tdark.
DR PRO; PR:Q0VAA2; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q0VAA2; protein.
DR Bgee; ENSG00000100565; Expressed in left testis and 72 other tissues.
DR ExpressionAtlas; Q0VAA2; baseline and differential.
DR Genevisible; Q0VAA2; HS.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13516; LRR_6; 4.
PE 2: Evidence at transcript level;
KW Alternative splicing; Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..488
FT /note="Leucine-rich repeat-containing protein 74A"
FT /id="PRO_0000306172"
FT REPEAT 134..155
FT /note="LRR 1"
FT REPEAT 162..182
FT /note="LRR 2"
FT REPEAT 191..212
FT /note="LRR 3"
FT REPEAT 219..239
FT /note="LRR 4"
FT REPEAT 247..268
FT /note="LRR 5"
FT REPEAT 275..296
FT /note="LRR 6"
FT REPEAT 303..324
FT /note="LRR 7"
FT REPEAT 331..351
FT /note="LRR 8"
FT VAR_SEQ 1..92
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_028425"
FT VAR_SEQ 273..311
FT /note="NVTLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGG -> KSSDSTAAW
FT STWISVAMTSAMKGPPKSAKDWNPMKASEF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_028426"
FT VAR_SEQ 312..488
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_028427"
SQ SEQUENCE 488 AA; 54535 MW; F1D0B73BFCCCE933 CRC64;
MHIQFPSKPT LPRACWEGRI TAGSPGMPPD EIEIEPVRQS SDKMLYCEAE SPPTVEKVKP
ARENSETDLE IEDDEKFFTT GQKELYLEAC KLMGVVPVSY FIRNMEESYV NLNHHGLGPR
GTKAIAIALV SNMAVTKLEL EDNCIMEEGV LSLVEMLQEN YYLQEMNISN NHLGLEGARI
ISDFFERNSS SIWSLELSGN DFKEDSAALL CQALSTNYQI KKLDLSHNQF SDVGGEHLGQ
MLAINVGLTS LDLSWNNFHT RGAVALCNGL RGNVTLTKLD LSMNGFGNEV ALALGEVLRL
NRCLVYLDIG GNDIGNEGAS KISKGLESNE SLRVLKLFLN PINMDGAILL ILAIKRNPKS
RMEELDISNV LVSEQFMKTL DGVYAVHPQL DVVFKAVQGL SPKKTIFLLT NPMKLIQSYA
DQHKITIVDF FKSLNPTGTM KMSVDEFQKV MIEQNKVPLN QYQVREVIKK LDEKTGMVNF
SFLNTMKP
