ID   LR74A_RAT               Reviewed;         479 AA.
AC   A0JPI9; Q4KLZ5;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Leucine-rich repeat-containing protein 74A {ECO:0000250|UniProtKB:Q0VAA2};
DE   AltName: Full=Leucine-rich repeat-containing protein 74 {ECO:0000312|RGD:1564488};
GN   Name=Lrrc74a {ECO:0000250|UniProtKB:Q0VAA2};
GN   Synonyms=Lrrc74 {ECO:0000312|RGD:1564488};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A0JPI9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A0JPI9-2; Sequence=VSP_028431, VSP_028432;
CC   -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC       premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC       decay. {ECO:0000305}.
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DR   EMBL; BC098927; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BC127444; AAI27445.1; -; mRNA.
DR   RefSeq; NP_001032872.2; NM_001037783.2. [A0JPI9-1]
DR   AlphaFoldDB; A0JPI9; -.
DR   SMR; A0JPI9; -.
DR   PhosphoSitePlus; A0JPI9; -.
DR   PRIDE; A0JPI9; -.
DR   Ensembl; ENSRNOT00000098897; ENSRNOP00000086029; ENSRNOG00000052456. [A0JPI9-1]
DR   GeneID; 314328; -.
DR   KEGG; rno:314328; -.
DR   UCSC; RGD:1564488; rat. [A0JPI9-1]
DR   CTD; 145497; -.
DR   RGD; 1564488; Lrrc74a.
DR   GeneTree; ENSGT00940000154297; -.
DR   InParanoid; A0JPI9; -.
DR   OrthoDB; 1463268at2759; -.
DR   PhylomeDB; A0JPI9; -.
DR   PRO; PR:A0JPI9; -.
DR   Proteomes; UP000002494; Chromosome 6.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13516; LRR_6; 6.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..479
FT                   /note="Leucine-rich repeat-containing protein 74A"
FT                   /id="PRO_0000306174"
FT   REPEAT          119..140
FT                   /note="LRR 1"
FT   REPEAT          147..167
FT                   /note="LRR 2"
FT   REPEAT          176..197
FT                   /note="LRR 3"
FT   REPEAT          204..225
FT                   /note="LRR 4"
FT   REPEAT          232..253
FT                   /note="LRR 5"
FT   REPEAT          260..281
FT                   /note="LRR 6"
FT   REPEAT          288..309
FT                   /note="LRR 7"
FT   REPEAT          316..336
FT                   /note="LRR 8"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         257..262
FT                   /note="TNVTLK -> LPSPGD (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_028431"
FT   VAR_SEQ         263..479
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_028432"
SQ   SEQUENCE   479 AA;  53227 MW;  257E8BC701CEA73E CRC64;
     MDDDDIEPLE YETKDETEAA LAPQSSEDTL YCEAEAAPSV EKEKPTREDS ETDLEIEDTE
     KFFSIGQKEL YLEACKLVGV VPVSYFIRNM EESCMNLNHH GLGPMGIKAI AITLVSNTTV
     LKLELEDNSI QEEGILSLME MLHENYYLQE LNVSDNNLGL EGARIISDFL QENNSSLWKL
     KLSGNKFKEE CALLLCQALS SNYRIRSLNL SHNEFSDTAG EYLGQMLALN VGLQSLNLSW
     NHFNVRGAVA LCNGLRTNVT LKKLDVSMNG FGNDGALALG DTLKLNSCLV YVDVSRNGIT
     NEGASRISKG LENNECLQVL KLFLNPVSLE GAYSLILAIK RNPKSRMEDL DISNVLVSEQ
     FVKVLDGVCA IHPQLDVVYK GLQGLSTKKT VSLETNPIKL IQNYTDQNKI SVVEFFKSLN
     PSGLMTMPVG DFRKAIIQQT NIPINRYQAR ELIKKLEEKN GMVNFSGFKS LKVTAAGQL