LR74B_HUMAN
ID LR74B_HUMAN Reviewed; 392 AA.
AC Q6ZQY2;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-NOV-2014, sequence version 3.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Leucine-rich repeat-containing protein 74B {ECO:0000312|HGNC:HGNC:34301};
GN Name=LRRC74B {ECO:0000312|HGNC:HGNC:34301};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Fetal brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6ZQY2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZQY2-2; Sequence=VSP_031321;
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DR EMBL; AK128646; BAC87547.1; -; mRNA.
DR EMBL; AC002472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC028231; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS77654.1; -. [Q6ZQY2-1]
DR RefSeq; NP_001277935.1; NM_001291006.1. [Q6ZQY2-1]
DR AlphaFoldDB; Q6ZQY2; -.
DR SMR; Q6ZQY2; -.
DR STRING; 9606.ENSP00000394078; -.
DR GlyGen; Q6ZQY2; 1 site, 1 O-linked glycan (1 site).
DR PhosphoSitePlus; Q6ZQY2; -.
DR BioMuta; LRRC74B; -.
DR MassIVE; Q6ZQY2; -.
DR PaxDb; Q6ZQY2; -.
DR PeptideAtlas; Q6ZQY2; -.
DR PRIDE; Q6ZQY2; -.
DR Antibodypedia; 62520; 25 antibodies from 9 providers.
DR DNASU; 400891; -.
DR Ensembl; ENST00000442047.2; ENSP00000394078.2; ENSG00000187905.10. [Q6ZQY2-1]
DR GeneID; 400891; -.
DR KEGG; hsa:400891; -.
DR MANE-Select; ENST00000442047.3; ENSP00000394078.2; NM_001291006.2; NP_001277935.1.
DR UCSC; uc062bxn.1; human. [Q6ZQY2-1]
DR CTD; 400891; -.
DR GeneCards; LRRC74B; -.
DR HGNC; HGNC:34301; LRRC74B.
DR HPA; ENSG00000187905; Group enriched (brain, choroid plexus, fallopian tube, lung, testis).
DR neXtProt; NX_Q6ZQY2; -.
DR OpenTargets; ENSG00000187905; -.
DR VEuPathDB; HostDB:ENSG00000187905; -.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00940000154297; -.
DR HOGENOM; CLU_017147_0_0_1; -.
DR OMA; CIKTGAC; -.
DR OrthoDB; 819226at2759; -.
DR PathwayCommons; Q6ZQY2; -.
DR SignaLink; Q6ZQY2; -.
DR BioGRID-ORCS; 400891; 0 hits in 103 CRISPR screens.
DR GenomeRNAi; 400891; -.
DR Pharos; Q6ZQY2; Tdark.
DR PRO; PR:Q6ZQY2; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q6ZQY2; protein.
DR Bgee; ENSG00000187905; Expressed in right uterine tube and 56 other tissues.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13516; LRR_6; 7.
PE 2: Evidence at transcript level;
KW Alternative splicing; Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..392
FT /note="Leucine-rich repeat-containing protein 74B"
FT /id="PRO_0000318964"
FT REPEAT 106..129
FT /note="LRR 1"
FT REPEAT 134..157
FT /note="LRR 2"
FT REPEAT 162..185
FT /note="LRR 3"
FT REPEAT 192..213
FT /note="LRR 4"
FT REPEAT 220..241
FT /note="LRR 5"
FT REPEAT 248..269
FT /note="LRR 6"
FT REPEAT 276..297
FT /note="LRR 7"
FT REPEAT 304..325
FT /note="LRR 8"
FT REPEAT 334..356
FT /note="LRR 9"
FT REGION 24..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 139..392
FT /note="DVDLSENQLGVAGAQALCAALTVNQAMRKMQLSGNGLEEQAAQHLAELLLAH
FT TDLKSLDLSYNQLNDQAGETLGPALAENTGLTELNVSWNHLRGPGAVAFARGLEANIFL
FT KVLDISYNGFGDPGASAVGEALKANNVLEELNMSNNRISAMGALSLGLGLRVNQTLRIL
FT VVSRNPMRSEGCFGLLKSVQDNPASALELLDFSDIQVNAEFDGLASSVRGILPELCIKT
FT GACRVEYKKELLPVFRSALPASVPK -> GRCWVWGRWAGVSSFSSGMCLHR (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_031321"
FT VARIANT 3
FT /note="G -> R (in dbSNP:rs12170538)"
FT /id="VAR_038923"
FT VARIANT 77
FT /note="R -> C (in dbSNP:rs9620774)"
FT /id="VAR_038924"
SQ SEQUENCE 392 AA; 41621 MW; F75C5F94A2158C66 CRC64;
MRGSCERSGE DEEQKEEAMV ACGRLSGVPE AEQGPEANWD SDLETEGTDG LGELVRDTLY
LRSCRAHSVV PISCFLRQGS AQELNLRHRG LGPQGARALA SSLSSNPYVK RLDLRDNGLC
GAGAEALAGA LSKSSSIHDV DLSENQLGVA GAQALCAALT VNQAMRKMQL SGNGLEEQAA
QHLAELLLAH TDLKSLDLSY NQLNDQAGET LGPALAENTG LTELNVSWNH LRGPGAVAFA
RGLEANIFLK VLDISYNGFG DPGASAVGEA LKANNVLEEL NMSNNRISAM GALSLGLGLR
VNQTLRILVV SRNPMRSEGC FGLLKSVQDN PASALELLDF SDIQVNAEFD GLASSVRGIL
PELCIKTGAC RVEYKKELLP VFRSALPASV PK
