LR74B_MOUSE
ID LR74B_MOUSE Reviewed; 391 AA.
AC Q14BP6; Q3UPS2; Q8BYL7;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Leucine-rich repeat-containing protein 74B {ECO:0000312|MGI:MGI:1921935};
GN Name=Lrrc74b {ECO:0000312|MGI:MGI:1921935};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Head, Hypothalamus, and Oviduct;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q14BP6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q14BP6-2; Sequence=VSP_028428;
CC Name=3;
CC IsoId=Q14BP6-3; Sequence=VSP_028429, VSP_028430;
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DR EMBL; AK039092; BAC30235.1; -; mRNA.
DR EMBL; AK132588; BAE21248.1; -; mRNA.
DR EMBL; AK143245; BAE25323.1; -; mRNA.
DR EMBL; AK161226; BAE36250.1; -; mRNA.
DR EMBL; BC115678; AAI15679.1; -; mRNA.
DR EMBL; BC115679; AAI15680.1; -; mRNA.
DR CCDS; CCDS28006.2; -. [Q14BP6-1]
DR CCDS; CCDS49777.1; -. [Q14BP6-2]
DR RefSeq; NP_001138907.1; NM_001145435.1. [Q14BP6-2]
DR RefSeq; NP_083329.2; NM_029053.3. [Q14BP6-1]
DR AlphaFoldDB; Q14BP6; -.
DR SMR; Q14BP6; -.
DR STRING; 10090.ENSMUSP00000097699; -.
DR iPTMnet; Q14BP6; -.
DR PhosphoSitePlus; Q14BP6; -.
DR EPD; Q14BP6; -.
DR MaxQB; Q14BP6; -.
DR PaxDb; Q14BP6; -.
DR PRIDE; Q14BP6; -.
DR ProteomicsDB; 252494; -. [Q14BP6-1]
DR ProteomicsDB; 252495; -. [Q14BP6-2]
DR ProteomicsDB; 252496; -. [Q14BP6-3]
DR Antibodypedia; 62520; 25 antibodies from 9 providers.
DR Ensembl; ENSMUST00000023442; ENSMUSP00000023442; ENSMUSG00000022759. [Q14BP6-2]
DR Ensembl; ENSMUST00000100123; ENSMUSP00000097699; ENSMUSG00000022759. [Q14BP6-1]
DR Ensembl; ENSMUST00000232637; ENSMUSP00000155867; ENSMUSG00000022759. [Q14BP6-3]
DR GeneID; 74685; -.
DR KEGG; mmu:74685; -.
DR UCSC; uc007yle.2; mouse. [Q14BP6-1]
DR UCSC; uc007ylf.2; mouse. [Q14BP6-2]
DR CTD; 400891; -.
DR MGI; MGI:1921935; Lrrc74b.
DR VEuPathDB; HostDB:ENSMUSG00000022759; -.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00940000154297; -.
DR HOGENOM; CLU_017147_0_0_1; -.
DR InParanoid; Q14BP6; -.
DR OMA; CIKTGAC; -.
DR OrthoDB; 819226at2759; -.
DR PhylomeDB; Q14BP6; -.
DR TreeFam; TF329403; -.
DR BioGRID-ORCS; 74685; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Lrrc74b; mouse.
DR PRO; PR:Q14BP6; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q14BP6; protein.
DR Bgee; ENSMUSG00000022759; Expressed in knee joint and 98 other tissues.
DR Genevisible; Q14BP6; MM.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13516; LRR_6; 7.
DR PROSITE; PS51450; LRR; 4.
PE 2: Evidence at transcript level;
KW Alternative splicing; Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..391
FT /note="Leucine-rich repeat-containing protein 74B"
FT /id="PRO_0000306173"
FT REPEAT 106..126
FT /note="LRR 1"
FT REPEAT 134..154
FT /note="LRR 2"
FT REPEAT 162..182
FT /note="LRR 3"
FT REPEAT 190..211
FT /note="LRR 4"
FT REPEAT 218..239
FT /note="LRR 5"
FT REPEAT 246..259
FT /note="LRR 6"
FT REPEAT 274..294
FT /note="LRR 7"
FT REPEAT 302..323
FT /note="LRR 8"
FT REPEAT 332..354
FT /note="LRR 9"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 371..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 308..339
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028428"
FT VAR_SEQ 308..310
FT /note="ISK -> VCW (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028429"
FT VAR_SEQ 311..391
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028430"
SQ SEQUENCE 391 AA; 41701 MW; 6D631E3347329DFC CRC64;
MKGPCEVQKN EDQEGEAAAT GPQAETLEAE RSWTADSHSA LEAEGTHGLG ERVMATLYLK
SCRANSVVPV SCLLRQEGAS ELNLRHRGLG PQGVRALASV LTSNPYIKRL DLRDNGLCGA
GAEALADVLR KNSIISDVDL SENQIGAAGL QAICTALALN PTVEKMQLQG NRLEEQAAQH
LAALLLHHRG LKSLDLSYNQ LNDLAGEILG PAVAENTGLT ELNLSWNHLR GLGATAFARG
LEANIFLKVL DISHNGFGDS GASAIGDALR VNNVLEELNM RNNRISVSGA LKLGLGLQVN
QTLRILIISK NPIRSDGCVG LLKSVRNNKS SALELLDVSD IQVSRECEDL ASSMSEILPG
LCIKRYTSRR KDWPQASTPS QPASAPSDSG L
