LR75A_MOUSE
ID LR75A_MOUSE Reviewed; 339 AA.
AC Q7TSF4; Q3UIX7; Q811G5;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Leucine-rich repeat-containing protein 75A;
DE AltName: Full=Leucine-rich repeat-containing protein FAM211A;
GN Name=Lrrc75a; Synonyms=Fam211a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Amnion;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=Czech II; TISSUE=Limb, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-322, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-322 AND THR-325, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7TSF4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7TSF4-2; Sequence=VSP_025136;
CC -!- SIMILARITY: Belongs to the LRRC75 family. {ECO:0000305}.
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DR EMBL; AK146714; BAE27379.1; -; mRNA.
DR EMBL; AL596181; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC046404; AAH46404.1; -; mRNA.
DR EMBL; BC053455; AAH53455.1; -; mRNA.
DR CCDS; CCDS24828.1; -. [Q7TSF4-1]
DR RefSeq; NP_942561.1; NM_198861.1. [Q7TSF4-1]
DR RefSeq; XP_006532640.1; XM_006532577.3.
DR AlphaFoldDB; Q7TSF4; -.
DR STRING; 10090.ENSMUSP00000062489; -.
DR iPTMnet; Q7TSF4; -.
DR PhosphoSitePlus; Q7TSF4; -.
DR MaxQB; Q7TSF4; -.
DR PaxDb; Q7TSF4; -.
DR PeptideAtlas; Q7TSF4; -.
DR PRIDE; Q7TSF4; -.
DR ProteomicsDB; 252663; -. [Q7TSF4-1]
DR ProteomicsDB; 252664; -. [Q7TSF4-2]
DR Antibodypedia; 25337; 19 antibodies from 10 providers.
DR DNASU; 192976; -.
DR Ensembl; ENSMUST00000057194; ENSMUSP00000062489; ENSMUSG00000046417. [Q7TSF4-1]
DR GeneID; 192976; -.
DR KEGG; mmu:192976; -.
DR UCSC; uc007jjm.1; mouse. [Q7TSF4-1]
DR CTD; 388341; -.
DR MGI; MGI:2682293; Lrrc75a.
DR VEuPathDB; HostDB:ENSMUSG00000046417; -.
DR eggNOG; ENOG502QVX0; Eukaryota.
DR GeneTree; ENSGT00940000161370; -.
DR HOGENOM; CLU_050536_0_0_1; -.
DR InParanoid; Q7TSF4; -.
DR OMA; ISMIQDM; -.
DR OrthoDB; 824676at2759; -.
DR PhylomeDB; Q7TSF4; -.
DR TreeFam; TF332831; -.
DR BioGRID-ORCS; 192976; 2 hits in 70 CRISPR screens.
DR ChiTaRS; Lrrc75a; mouse.
DR PRO; PR:Q7TSF4; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q7TSF4; protein.
DR Bgee; ENSMUSG00000046417; Expressed in ear vesicle and 184 other tissues.
DR Genevisible; Q7TSF4; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
PE 1: Evidence at protein level;
KW Alternative splicing; Leucine-rich repeat; Phosphoprotein;
KW Reference proteome; Repeat.
FT CHAIN 1..339
FT /note="Leucine-rich repeat-containing protein 75A"
FT /id="PRO_0000286625"
FT REPEAT 203..216
FT /note="LRR 1"
FT REPEAT 228..241
FT /note="LRR 2"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 322
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 325
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 1..85
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025136"
SQ SEQUENCE 339 AA; 37574 MW; A5674A624291CE84 CRC64;
MGTRQTKGSL AERASPGAAP GPRRERPDFW ASLLLRAGDK AGRAGSGLPP YHRRVGMVQE
LLRMVRQGRR EEAGTLLQHL RQDLGMESTS LDDVLYRYAS FRNLVDPITH DLIISLARYI
HCPKPEGDAM GAMEKLCRQL TYHLSPHSQW RRHRGLKRKP QACLKALLSG NPPDNMVDLS
GIPLTSRDLE RVTSYLQRCG EQVDSVELGF TGLTDDMVLQ LLPALSTLPR LTTLALNGNR
LTRALLRDLT DTLKDPSKFP NVTWIDLGNN VDIFSLPQPF LLSLRKRSPK QGHLPTILEL
GEGPGTGEEA REGTDQQDPI GSPVTPARGQ ESTECVIQT
