LR75B_HUMAN
ID LR75B_HUMAN Reviewed; 315 AA.
AC Q2VPJ9; Q8N0S9; Q8N8B1;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Leucine-rich repeat-containing protein 75B;
DE AltName: Full=Leucine-rich repeat-containing protein FAM211B;
GN Name=LRRC75B; Synonyms=C22orf36, FAM211B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q2VPJ9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q2VPJ9-2; Sequence=VSP_021172, VSP_021173;
CC -!- SIMILARITY: Belongs to the LRRC75 family. {ECO:0000305}.
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DR EMBL; AK097054; BAC04937.1; -; mRNA.
DR EMBL; BC032388; AAH32388.1; -; mRNA.
DR EMBL; BC108684; AAI08685.1; -; mRNA.
DR CCDS; CCDS42991.1; -. [Q2VPJ9-1]
DR RefSeq; NP_997527.2; NM_207644.2. [Q2VPJ9-1]
DR AlphaFoldDB; Q2VPJ9; -.
DR BioGRID; 132882; 1.
DR STRING; 9606.ENSP00000320520; -.
DR PhosphoSitePlus; Q2VPJ9; -.
DR BioMuta; LRRC75B; -.
DR DMDM; 118573588; -.
DR PaxDb; Q2VPJ9; -.
DR PeptideAtlas; Q2VPJ9; -.
DR PRIDE; Q2VPJ9; -.
DR Antibodypedia; 265; 61 antibodies from 13 providers.
DR DNASU; 388886; -.
DR Ensembl; ENST00000318753.13; ENSP00000320520.8; ENSG00000178026.13. [Q2VPJ9-1]
DR GeneID; 388886; -.
DR KEGG; hsa:388886; -.
DR MANE-Select; ENST00000318753.13; ENSP00000320520.8; NM_207644.3; NP_997527.2.
DR UCSC; uc003aaq.3; human. [Q2VPJ9-1]
DR CTD; 388886; -.
DR DisGeNET; 388886; -.
DR GeneCards; LRRC75B; -.
DR HGNC; HGNC:33155; LRRC75B.
DR HPA; ENSG00000178026; Low tissue specificity.
DR neXtProt; NX_Q2VPJ9; -.
DR OpenTargets; ENSG00000178026; -.
DR PharmGKB; PA162378982; -.
DR VEuPathDB; HostDB:ENSG00000178026; -.
DR eggNOG; ENOG502QRJY; Eukaryota.
DR GeneTree; ENSGT00940000162815; -.
DR HOGENOM; CLU_050536_2_0_1; -.
DR InParanoid; Q2VPJ9; -.
DR OMA; PQACCTR; -.
DR PhylomeDB; Q2VPJ9; -.
DR TreeFam; TF332831; -.
DR PathwayCommons; Q2VPJ9; -.
DR BioGRID-ORCS; 388886; 12 hits in 1071 CRISPR screens.
DR GenomeRNAi; 388886; -.
DR Pharos; Q2VPJ9; Tdark.
DR PRO; PR:Q2VPJ9; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q2VPJ9; protein.
DR Bgee; ENSG00000178026; Expressed in kidney epithelium and 155 other tissues.
DR ExpressionAtlas; Q2VPJ9; baseline and differential.
DR Genevisible; Q2VPJ9; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
PE 2: Evidence at transcript level;
KW Alternative splicing; Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..315
FT /note="Leucine-rich repeat-containing protein 75B"
FT /id="PRO_0000254046"
FT REPEAT 182..195
FT /note="LRR 1"
FT REPEAT 207..220
FT /note="LRR 2"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 60..152
FT /note="DLGLERTLLPDILYRDVAFLNPVDPISHDLLVNLARDLQCPKKDYELWKSSD
FT KICRQLIYHLTPHSKQQQGSSLRQRKTQSCLKSSLQKTLLA -> AREGAVRPWAGGQG
FT GSGGLGVWEARGYGLWACIRREARRSWSLARAGGFRGRDRLQHAGSCVGERATAWSEGW
FT VRSADRVEEGAAECVRVFGV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_021172"
FT VAR_SEQ 153..315
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_021173"
FT VARIANT 140
FT /note="S -> R (in dbSNP:rs743370)"
FT /id="VAR_051125"
SQ SEQUENCE 315 AA; 34740 MW; 099B03832A2DD370 CRC64;
MGARLGRRAG PEAGSEAGAA AGCGPAPYER RVRWLREIQS TLRERRPERA RQLLRLLRQD
LGLERTLLPD ILYRDVAFLN PVDPISHDLL VNLARDLQCP KKDYELWKSS DKICRQLIYH
LTPHSKQQQG SSLRQRKTQS CLKSSLQKTL LAGETVDLSG IPLSTQDVQH ITRYLSSHGA
VLAVLDLSFT GLSDELLHLL LPSLWALPRL TQLLLNGNRL TRATARKLTD AIKDTTKFPA
LAWVDLGNNV DVASLPQPLL VGLRRRLSQR TSLPTIYEGL DLEPEGSAAG ATTPASTWDS
TAAGLGPEPQ ACCAR
