LR75B_MOUSE
ID LR75B_MOUSE Reviewed; 306 AA.
AC Q7TPD7; Q3V1Q4;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Leucine-rich repeat-containing protein 75B;
DE AltName: Full=Leucine-rich repeat-containing protein FAM211B;
GN Name=Lrrc75b; Synonyms=Fam211b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 24-306.
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SIMILARITY: Belongs to the LRRC75 family. {ECO:0000305}.
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DR EMBL; BC055322; AAH55322.1; -; mRNA.
DR EMBL; BC056492; AAH56492.1; -; mRNA.
DR EMBL; AK132309; BAE21096.1; -; mRNA.
DR CCDS; CCDS35937.1; -.
DR RefSeq; NP_942560.1; NM_198860.2.
DR AlphaFoldDB; Q7TPD7; -.
DR STRING; 10090.ENSMUSP00000053085; -.
DR iPTMnet; Q7TPD7; -.
DR PhosphoSitePlus; Q7TPD7; -.
DR PaxDb; Q7TPD7; -.
DR PRIDE; Q7TPD7; -.
DR ProteomicsDB; 252497; -.
DR Antibodypedia; 265; 61 antibodies from 13 providers.
DR DNASU; 192734; -.
DR Ensembl; ENSMUST00000051129; ENSMUSP00000053085; ENSMUSG00000046807.
DR GeneID; 192734; -.
DR KEGG; mmu:192734; -.
DR UCSC; uc029qyw.1; mouse.
DR CTD; 388886; -.
DR MGI; MGI:2143657; Lrrc75b.
DR VEuPathDB; HostDB:ENSMUSG00000046807; -.
DR eggNOG; ENOG502QRJY; Eukaryota.
DR GeneTree; ENSGT00940000162815; -.
DR HOGENOM; CLU_050536_2_0_1; -.
DR InParanoid; Q7TPD7; -.
DR OMA; PQACCTR; -.
DR OrthoDB; 824676at2759; -.
DR PhylomeDB; Q7TPD7; -.
DR TreeFam; TF332831; -.
DR BioGRID-ORCS; 192734; 0 hits in 71 CRISPR screens.
DR PRO; PR:Q7TPD7; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q7TPD7; protein.
DR Bgee; ENSMUSG00000046807; Expressed in vestibular membrane of cochlear duct and 157 other tissues.
DR ExpressionAtlas; Q7TPD7; baseline and differential.
DR Genevisible; Q7TPD7; MM.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..306
FT /note="Leucine-rich repeat-containing protein 75B"
FT /id="PRO_0000254047"
FT REPEAT 173..186
FT /note="LRR 1"
FT REPEAT 198..211
FT /note="LRR 2"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 306 AA; 34160 MW; BD61505F7789FB7A CRC64;
MGARLGRRAR ADAPAAPSAG PAPYERRVRW LREIQSTLRE RRPERARQLL RLLRQDLGLE
GNLLTDILHR NVTFLNLVDP ISHDLLVNLA RDLQCPKKDH ELWKSSDKIC RQLIYHLTPH
SKRKHHRKTQ SSLKSSLQKT LLVGETVDLS GIPLSARDVQ HISRYLDTRG VELVVLDLSF
TELSDELLHL LLPSLWALPR LTQLLLNGNR LTRAAARELT EAIKDTAKFP VLAWVDLGNN
VDVSSLPQPL LVGLRRRLSQ HTSLPTIYEG LDLEPGGGMA ETTAAVSTWG SAATEAGPEP
QGCCAR
