LRAD1_HUMAN
ID LRAD1_HUMAN Reviewed; 205 AA.
AC Q5T700; A0PJY0; B7ZME3; Q5T6Z9;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Low-density lipoprotein receptor class A domain-containing protein 1;
GN Name=LDLRAD1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q5T700; Q96K78: ADGRG7; NbExp=7; IntAct=EBI-10173166, EBI-10290200;
CC Q5T700; Q86W74-2: ANKRD46; NbExp=3; IntAct=EBI-10173166, EBI-12109402;
CC Q5T700; P29972: AQP1; NbExp=3; IntAct=EBI-10173166, EBI-745213;
CC Q5T700; Q12982: BNIP2; NbExp=3; IntAct=EBI-10173166, EBI-752094;
CC Q5T700; Q12983: BNIP3; NbExp=6; IntAct=EBI-10173166, EBI-749464;
CC Q5T700; O60238: BNIP3L; NbExp=4; IntAct=EBI-10173166, EBI-849893;
CC Q5T700; Q96FZ5: CMTM7; NbExp=3; IntAct=EBI-10173166, EBI-2807956;
CC Q5T700; Q4LDR2: CTXN3; NbExp=3; IntAct=EBI-10173166, EBI-12019274;
CC Q5T700; Q07325: CXCL9; NbExp=3; IntAct=EBI-10173166, EBI-3911467;
CC Q5T700; Q15125: EBP; NbExp=3; IntAct=EBI-10173166, EBI-3915253;
CC Q5T700; P54852: EMP3; NbExp=3; IntAct=EBI-10173166, EBI-3907816;
CC Q5T700; Q96F15: GIMAP5; NbExp=6; IntAct=EBI-10173166, EBI-6166686;
CC Q5T700; O00155: GPR25; NbExp=3; IntAct=EBI-10173166, EBI-10178951;
CC Q5T700; P24593: IGFBP5; NbExp=3; IntAct=EBI-10173166, EBI-720480;
CC Q5T700; Q13571: LAPTM5; NbExp=3; IntAct=EBI-10173166, EBI-2865663;
CC Q5T700; P21145: MAL; NbExp=7; IntAct=EBI-10173166, EBI-3932027;
CC Q5T700; Q13021: MALL; NbExp=7; IntAct=EBI-10173166, EBI-750078;
CC Q5T700; Q9P0N8: MARCHF2; NbExp=7; IntAct=EBI-10173166, EBI-10317612;
CC Q5T700; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-10173166, EBI-10317425;
CC Q5T700; Q6UX06: OLFM4; NbExp=7; IntAct=EBI-10173166, EBI-2804156;
CC Q5T700; P26678: PLN; NbExp=4; IntAct=EBI-10173166, EBI-692836;
CC Q5T700; Q8IY26: PLPP6; NbExp=3; IntAct=EBI-10173166, EBI-11721828;
CC Q5T700; P53801: PTTG1IP; NbExp=3; IntAct=EBI-10173166, EBI-3906138;
CC Q5T700; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-10173166, EBI-8652744;
CC Q5T700; P43005: SLC1A1; NbExp=4; IntAct=EBI-10173166, EBI-745376;
CC Q5T700; Q96JW4: SLC41A2; NbExp=3; IntAct=EBI-10173166, EBI-10290130;
CC Q5T700; Q9BVK8: TMEM147; NbExp=7; IntAct=EBI-10173166, EBI-348587;
CC Q5T700; Q8WZ59: TMEM190; NbExp=7; IntAct=EBI-10173166, EBI-10278423;
CC Q5T700; A2RU14: TMEM218; NbExp=8; IntAct=EBI-10173166, EBI-10173151;
CC Q5T700; Q9BSE2: TMEM79; NbExp=3; IntAct=EBI-10173166, EBI-8649725;
CC Q5T700; Q9H1C4: UNC93B1; NbExp=3; IntAct=EBI-10173166, EBI-4401271;
CC Q5T700; O75379: VAMP4; NbExp=3; IntAct=EBI-10173166, EBI-744953;
CC Q5T700; Q9UEU0: VTI1B; NbExp=8; IntAct=EBI-10173166, EBI-723716;
CC Q5T700; O95159: ZFPL1; NbExp=3; IntAct=EBI-10173166, EBI-718439;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q5T700-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5T700-2; Sequence=VSP_027617;
CC Name=3;
CC IsoId=Q5T700-3; Sequence=VSP_027618;
CC Name=4;
CC IsoId=Q5T700-4; Sequence=VSP_054532;
CC -!- SIMILARITY: Belongs to the LDLR family. {ECO:0000305}.
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DR EMBL; AL353898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC103740; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC127708; AAI27709.1; -; mRNA.
DR EMBL; BC127709; AAI27710.1; -; mRNA.
DR EMBL; BC140760; AAI40761.1; -; mRNA.
DR EMBL; BC144466; AAI44467.1; -; mRNA.
DR CCDS; CCDS30725.1; -. [Q5T700-1]
DR CCDS; CCDS60145.1; -. [Q5T700-3]
DR CCDS; CCDS60146.1; -. [Q5T700-4]
DR CCDS; CCDS60147.1; -. [Q5T700-2]
DR RefSeq; NP_001010978.2; NM_001010978.3. [Q5T700-1]
DR RefSeq; NP_001263321.1; NM_001276392.1. [Q5T700-2]
DR RefSeq; NP_001263322.1; NM_001276393.1. [Q5T700-4]
DR RefSeq; NP_001263323.1; NM_001276394.1. [Q5T700-3]
DR AlphaFoldDB; Q5T700; -.
DR BioGRID; 132783; 209.
DR IntAct; Q5T700; 34.
DR STRING; 9606.ENSP00000360411; -.
DR PhosphoSitePlus; Q5T700; -.
DR BioMuta; LDLRAD1; -.
DR DMDM; 74745299; -.
DR MassIVE; Q5T700; -.
DR PaxDb; Q5T700; -.
DR PeptideAtlas; Q5T700; -.
DR PRIDE; Q5T700; -.
DR ProteomicsDB; 64626; -. [Q5T700-1]
DR ProteomicsDB; 64627; -. [Q5T700-2]
DR ProteomicsDB; 64628; -. [Q5T700-3]
DR ProteomicsDB; 7255; -.
DR Antibodypedia; 46892; 111 antibodies from 23 providers.
DR DNASU; 388633; -.
DR Ensembl; ENST00000371360.2; ENSP00000360411.1; ENSG00000203985.11. [Q5T700-1]
DR Ensembl; ENST00000371362.7; ENSP00000360413.3; ENSG00000203985.11. [Q5T700-3]
DR Ensembl; ENST00000420619.5; ENSP00000411017.1; ENSG00000203985.11. [Q5T700-2]
DR Ensembl; ENST00000545928.5; ENSP00000445871.1; ENSG00000203985.11. [Q5T700-4]
DR GeneID; 388633; -.
DR KEGG; hsa:388633; -.
DR MANE-Select; ENST00000371360.2; ENSP00000360411.1; NM_001010978.4; NP_001010978.2.
DR UCSC; uc001cwm.3; human. [Q5T700-1]
DR CTD; 388633; -.
DR DisGeNET; 388633; -.
DR GeneCards; LDLRAD1; -.
DR HGNC; HGNC:32069; LDLRAD1.
DR HPA; ENSG00000203985; Tissue enriched (fallopian).
DR neXtProt; NX_Q5T700; -.
DR OpenTargets; ENSG00000203985; -.
DR PharmGKB; PA142671554; -.
DR VEuPathDB; HostDB:ENSG00000203985; -.
DR eggNOG; ENOG502S044; Eukaryota.
DR GeneTree; ENSGT00390000008557; -.
DR HOGENOM; CLU_115457_0_0_1; -.
DR InParanoid; Q5T700; -.
DR OMA; CSCIPRR; -.
DR OrthoDB; 1360842at2759; -.
DR PhylomeDB; Q5T700; -.
DR TreeFam; TF343451; -.
DR PathwayCommons; Q5T700; -.
DR SignaLink; Q5T700; -.
DR BioGRID-ORCS; 388633; 10 hits in 1060 CRISPR screens.
DR GenomeRNAi; 388633; -.
DR Pharos; Q5T700; Tdark.
DR PRO; PR:Q5T700; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5T700; protein.
DR Bgee; ENSG00000203985; Expressed in right uterine tube and 38 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 4.10.400.10; -; 2.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR040093; LRAD1.
DR PANTHER; PTHR22722:SF5; PTHR22722:SF5; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00192; LDLa; 3.
DR SUPFAM; SSF57424; SSF57424; 2.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Disulfide bond; Lipoprotein; Membrane; Receptor;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..205
FT /note="Low-density lipoprotein receptor class A domain-
FT containing protein 1"
FT /id="PRO_0000299376"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 71..114
FT /note="LDL-receptor class A 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 115..161
FT /note="LDL-receptor class A 2; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 162..203
FT /note="LDL-receptor class A 3; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 72..89
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 83..102
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 96..113
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 141..160
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 163..180
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 170..193
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT VAR_SEQ 1..66
FT /note="MNKVFPQGENGYTAAESKAHPGGEAGGGHLCCSRRGACLSASLLLLLATVAA
FT LIALVTILGLPSCT -> MQGTRAELSAHSPSRAAGNRRHEQGLP (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027617"
FT VAR_SEQ 25..114
FT /note="AGGGHLCCSRRGACLSASLLLLLATVAALIALVTILGLPSCTPGAQACITLT
FT NRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCR -> G (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027618"
FT VAR_SEQ 25..67
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_054532"
SQ SEQUENCE 205 AA; 21834 MW; 49CF4F64F9EC6C9A CRC64;
MNKVFPQGEN GYTAAESKAH PGGEAGGGHL CCSRRGACLS ASLLLLLATV AALIALVTIL
GLPSCTPGAQ ACITLTNRTG FLCHDQRSCI PASGVCDGVR TCTHGEDEDE SLCRDVPQSL
PHFLVAHCGD PASWIYSDQK CDGTNNCGDC SDELSPVTVC PPCGPGWWRC PSTFFKYCDC
IPRHLCRDHV QHCSDWSDEY ACPGP
