LRAD2_HUMAN
ID LRAD2_HUMAN Reviewed; 272 AA.
AC Q5SZI1; B9EJB3; Q6ZSN5;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Low-density lipoprotein receptor class A domain-containing protein 2;
DE Flags: Precursor;
GN Name=LDLRAD2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-134.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- SIMILARITY: Belongs to the LDLR family. {ECO:0000305}.
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DR EMBL; AK127275; BAC86913.1; -; mRNA.
DR EMBL; AL590103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471134; EAW94993.1; -; Genomic_DNA.
DR EMBL; BC146860; AAI46861.1; -; mRNA.
DR CCDS; CCDS30624.1; -.
DR RefSeq; NP_001013715.2; NM_001013693.2.
DR AlphaFoldDB; Q5SZI1; -.
DR SMR; Q5SZI1; -.
DR BioGRID; 135281; 1.
DR STRING; 9606.ENSP00000340988; -.
DR GlyGen; Q5SZI1; 1 site.
DR iPTMnet; Q5SZI1; -.
DR PhosphoSitePlus; Q5SZI1; -.
DR BioMuta; LDLRAD2; -.
DR DMDM; 74744157; -.
DR PaxDb; Q5SZI1; -.
DR PeptideAtlas; Q5SZI1; -.
DR PRIDE; Q5SZI1; -.
DR Antibodypedia; 30016; 136 antibodies from 24 providers.
DR DNASU; 401944; -.
DR Ensembl; ENST00000344642.7; ENSP00000340988.2; ENSG00000187942.12.
DR Ensembl; ENST00000543870.1; ENSP00000444097.1; ENSG00000187942.12.
DR GeneID; 401944; -.
DR KEGG; hsa:401944; -.
DR MANE-Select; ENST00000344642.7; ENSP00000340988.2; NM_001013693.3; NP_001013715.2.
DR UCSC; uc001bfg.1; human.
DR CTD; 401944; -.
DR DisGeNET; 401944; -.
DR GeneCards; LDLRAD2; -.
DR HGNC; HGNC:32071; LDLRAD2.
DR HPA; ENSG00000187942; Low tissue specificity.
DR MalaCards; LDLRAD2; -.
DR neXtProt; NX_Q5SZI1; -.
DR OpenTargets; ENSG00000187942; -.
DR PharmGKB; PA142671555; -.
DR VEuPathDB; HostDB:ENSG00000187942; -.
DR eggNOG; ENOG502R5YQ; Eukaryota.
DR GeneTree; ENSGT00390000004581; -.
DR HOGENOM; CLU_062033_1_0_1; -.
DR InParanoid; Q5SZI1; -.
DR OMA; APDTDCW; -.
DR OrthoDB; 967017at2759; -.
DR PhylomeDB; Q5SZI1; -.
DR TreeFam; TF333091; -.
DR PathwayCommons; Q5SZI1; -.
DR BioGRID-ORCS; 401944; 11 hits in 1061 CRISPR screens.
DR ChiTaRS; LDLRAD2; human.
DR GenomeRNAi; 401944; -.
DR Pharos; Q5SZI1; Tdark.
DR PRO; PR:Q5SZI1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5SZI1; protein.
DR Bgee; ENSG00000187942; Expressed in sural nerve and 93 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 2.60.120.290; -; 1.
DR Gene3D; 4.10.400.10; -; 1.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR042333; LDLRAD2.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24652; PTHR24652; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR SMART; SM00192; LDLa; 1.
DR SUPFAM; SSF49854; SSF49854; 1.
DR SUPFAM; SSF57424; SSF57424; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Lipoprotein; Membrane; Receptor;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..272
FT /note="Low-density lipoprotein receptor class A domain-
FT containing protein 2"
FT /id="PRO_0000299377"
FT TOPO_DOM 26..233
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..250
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 251..272
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 172..214
FT /note="LDL-receptor class A"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT REGION 202..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 173..184
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 179..199
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 191..213
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT VARIANT 134
FT /note="N -> T (in dbSNP:rs10917051)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_034812"
FT CONFLICT 114
FT /note="Q -> R (in Ref. 1; BAC86913)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 272 AA; 28581 MW; 31F9F3861DDD721B CRC64;
MEACCLLQLP QRLLLLGAAA LTATALETAD LAELCGQTWQ GDGLLLRSHA ASRRFYFVAP
DTDCGLWVQA AAPGDRIRFQ FRFFLVYSLT PAPPALNTSS PAPADPCAPG SYLQFYEGPP
GAPRPLGSPL CGLNIPVPVA SSGPFLGLRL VTRGRQPRVD FVGEVTSFRL GPCGAYFRCQ
NGRCIPSSLV CDPWGMDNCG DGSDQGSWSP ADCRGPSPVP SQTGSTDAHT SRSLTPSPAL
GSAGSLWIAA ERSSPAGRDP TRQDAALEGS TE
