ID   LRAD3_XENTR             Reviewed;         337 AA.
AC   A4IHY6;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Low-density lipoprotein receptor class A domain-containing protein 3 {ECO:0000250|UniProtKB:Q86YD5};
DE   Flags: Precursor;
GN   Name=ldlrad3 {ECO:0000250|UniProtKB:Q86YD5};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LDLR family. {ECO:0000305}.
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DR   EMBL; BC135753; AAI35754.1; -; mRNA.
DR   RefSeq; NP_001096330.1; NM_001102860.1.
DR   AlphaFoldDB; A4IHY6; -.
DR   STRING; 8364.ENSXETP00000047077; -.
DR   PaxDb; A4IHY6; -.
DR   DNASU; 100124916; -.
DR   GeneID; 100124916; -.
DR   KEGG; xtr:100124916; -.
DR   CTD; 143458; -.
DR   Xenbase; XB-GENE-989860; ldlrad3.
DR   eggNOG; KOG1215; Eukaryota.
DR   InParanoid; A4IHY6; -.
DR   OrthoDB; 885061at2759; -.
DR   Reactome; R-XTR-9758890; Transport of RCbl within the body.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000007552; Expressed in skeletal muscle tissue and 9 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0006898; P:receptor-mediated endocytosis; IBA:GO_Central.
DR   CDD; cd00112; LDLa; 3.
DR   Gene3D; 4.10.400.10; -; 3.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   Pfam; PF00057; Ldl_recept_a; 3.
DR   PRINTS; PR00261; LDLRECEPTOR.
DR   SMART; SM00192; LDLa; 3.
DR   SUPFAM; SSF57424; SSF57424; 3.
DR   PROSITE; PS01209; LDLRA_1; 3.
DR   PROSITE; PS50068; LDLRA_2; 3.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; Glycoprotein; Lipoprotein; Membrane;
KW   Receptor; Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..13
FT                   /evidence="ECO:0000255"
FT   CHAIN           14..337
FT                   /note="Low-density lipoprotein receptor class A domain-
FT                   containing protein 3"
FT                   /id="PRO_0000299380"
FT   TOPO_DOM        14..169
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        191..337
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          24..61
FT                   /note="LDL-receptor class A 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          66..103
FT                   /note="LDL-receptor class A 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          108..144
FT                   /note="LDL-receptor class A 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   REGION          243..337
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        279..322
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        20
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        101
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        25..38
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DISULFID        33..51
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DISULFID        45..60
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DISULFID        67..80
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DISULFID        74..93
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DISULFID        87..102
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DISULFID        109..121
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DISULFID        116..134
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DISULFID        128..143
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
SQ   SEQUENCE   337 AA;  37288 MW;  362E6485B7CE06B8 CRC64;
     MWLLYLILGS VESQLLPGNN HTTECNIPGN FMCSNGRCIP GGWQCDGNPD CFDESDEKEC
     PRARSRCGPN FFPCTSGIHC IIARFQCNGF EDCPDGSDEE NCTAHPLLCS NSRFHCKNHL
     CIDKSFVCDG QNNCLDNSDE EHCHSPQEPG SEQDYVSSEN QLLYYPSITY TIIGSSVIFV
     LVVALLALVL HHQRKRNLMS LPVHRLQHPL LLSRLVVLDH PHHCRVTYNV NNGIQYMSGQ
     GYQQPVSVES PPSYTEAVLD HSSRPPWFDL PPPPYPSDME SVSQTELPPY RSRTGSSASA
     GSTEHPRGTP CGTESPTEPQ DPTAAPSDDL PSTEVDV