LRAT1_HUMAN
ID LRAT1_HUMAN Reviewed; 292 AA.
AC Q96KN4; A6NP76; Q86UZ2; Q8NAH7; Q8TAM5;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Protein LRATD1 {ECO:0000305};
DE AltName: Full=LRAT domain-containing 1 {ECO:0000312|HGNC:HGNC:20743};
DE AltName: Full=Neurologic sensory protein 1;
DE Short=NSE1;
DE AltName: Full=Protein FAM84A;
GN Name=LRATD1 {ECO:0000312|HGNC:HGNC:20743}; Synonyms=FAM84A, NSE1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Hughes P.J., Stanway G.;
RT "Identification of a novel member of the H-rev107 protein family.";
RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Prostate;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP TISSUE SPECIFICITY, SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-38, AND
RP MUTAGENESIS OF SER-38 AND SER-67.
RX PubMed=16820875;
RA Kobayashi T., Masaki T., Sugiyama M., Atomi Y., Furukawa Y., Nakamura Y.;
RT "A gene encoding a family with sequence similarity 84, member A (FAM84A)
RT enhanced migration of human colon cancer cells.";
RL Int. J. Oncol. 29:341-347(2006).
CC -!- FUNCTION: May play a role in cell morphology and motility.
CC {ECO:0000269|PubMed:16820875}.
CC -!- INTERACTION:
CC Q96KN4; Q12774: ARHGEF5; NbExp=5; IntAct=EBI-11477916, EBI-602199;
CC Q96KN4; Q9UBB4: ATXN10; NbExp=3; IntAct=EBI-11477916, EBI-702390;
CC Q96KN4; Q8WWM9: CYGB; NbExp=3; IntAct=EBI-11477916, EBI-6309037;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16820875}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96KN4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96KN4-2; Sequence=VSP_018314;
CC -!- TISSUE SPECIFICITY: Only detected in testis. Highly expressed in colon
CC cancer cells. {ECO:0000269|PubMed:16820875}.
CC -!- SIMILARITY: Belongs to the LRATD family. {ECO:0000305}.
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DR EMBL; AJ417080; CAD10038.1; -; mRNA.
DR EMBL; AK092654; BAC03938.1; -; mRNA.
DR EMBL; AC011897; AAY15041.1; -; Genomic_DNA.
DR EMBL; CH471053; EAX00905.1; -; Genomic_DNA.
DR EMBL; BC026346; AAH26346.1; -; mRNA.
DR EMBL; BC052284; AAH52284.1; -; mRNA.
DR CCDS; CCDS1684.1; -. [Q96KN4-1]
DR RefSeq; NP_660158.2; NM_145175.3. [Q96KN4-1]
DR AlphaFoldDB; Q96KN4; -.
DR SMR; Q96KN4; -.
DR BioGRID; 127371; 15.
DR IntAct; Q96KN4; 4.
DR MINT; Q96KN4; -.
DR STRING; 9606.ENSP00000295092; -.
DR iPTMnet; Q96KN4; -.
DR PhosphoSitePlus; Q96KN4; -.
DR BioMuta; FAM84A; -.
DR DMDM; 97049335; -.
DR jPOST; Q96KN4; -.
DR MassIVE; Q96KN4; -.
DR MaxQB; Q96KN4; -.
DR PaxDb; Q96KN4; -.
DR PeptideAtlas; Q96KN4; -.
DR PRIDE; Q96KN4; -.
DR ProteomicsDB; 77087; -. [Q96KN4-1]
DR ProteomicsDB; 77088; -. [Q96KN4-2]
DR Antibodypedia; 26913; 92 antibodies from 21 providers.
DR DNASU; 151354; -.
DR Ensembl; ENST00000295092.3; ENSP00000295092.2; ENSG00000162981.14. [Q96KN4-1]
DR Ensembl; ENST00000331243.4; ENSP00000330681.4; ENSG00000162981.14. [Q96KN4-1]
DR GeneID; 151354; -.
DR KEGG; hsa:151354; -.
DR MANE-Select; ENST00000295092.3; ENSP00000295092.2; NM_145175.4; NP_660158.2.
DR UCSC; uc002rbz.3; human. [Q96KN4-1]
DR CTD; 151354; -.
DR DisGeNET; 151354; -.
DR GeneCards; LRATD1; -.
DR HGNC; HGNC:20743; LRATD1.
DR HPA; ENSG00000162981; Tissue enhanced (epididymis, intestine).
DR MIM; 611234; gene.
DR neXtProt; NX_Q96KN4; -.
DR OpenTargets; ENSG00000162981; -.
DR PharmGKB; PA142671854; -.
DR VEuPathDB; HostDB:ENSG00000162981; -.
DR eggNOG; ENOG502QPSG; Eukaryota.
DR GeneTree; ENSGT00940000161165; -.
DR HOGENOM; CLU_082142_0_0_1; -.
DR InParanoid; Q96KN4; -.
DR OMA; AQAPHWA; -.
DR OrthoDB; 953643at2759; -.
DR PhylomeDB; Q96KN4; -.
DR TreeFam; TF330836; -.
DR PathwayCommons; Q96KN4; -.
DR SignaLink; Q96KN4; -.
DR BioGRID-ORCS; 151354; 11 hits in 1064 CRISPR screens.
DR ChiTaRS; FAM84A; human.
DR GenomeRNAi; 151354; -.
DR Pharos; Q96KN4; Tbio.
DR PRO; PR:Q96KN4; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q96KN4; protein.
DR Bgee; ENSG00000162981; Expressed in ileal mucosa and 154 other tissues.
DR Genevisible; Q96KN4; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000902; P:cell morphogenesis; IMP:UniProtKB.
DR GO; GO:0048870; P:cell motility; IMP:UniProtKB.
DR InterPro; IPR007053; LRAT_dom.
DR InterPro; IPR043299; LRATD1_LRATD2.
DR PANTHER; PTHR46341; PTHR46341; 1.
DR Pfam; PF04970; LRAT; 1.
DR PROSITE; PS51934; LRAT; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..292
FT /note="Protein LRATD1"
FT /id="PRO_0000234425"
FT DOMAIN 133..228
FT /note="LRAT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01283"
FT MOD_RES 38
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:16820875"
FT VAR_SEQ 146..292
FT /note="VYVGGGQIIHLHQGEIRQDSLYEAGAANVGRVVNSWYRYRPLVAELVVQNAC
FT GHLGLKSEEICWTNSESFAAWCRFGKREFKAGGEVPAGTQPPQQQYYLKVHLGENKVHT
FT ARFHSLEDLIREKRRIDASGRLRVLQELADLVDDKE -> SRARRSAGRTRRASPPGAA
FT LASGSSRREGRCRQARSPRSSSTISRCTWERTRSTPPGFTAWKTSSARSAVSTPAAACE
FT CSRSSPTSWTTRSSRLGAAGPSASPAPRSLPFPAPGLRSQRFSTSAPPRHARPPPVARA
FT RAAPPHPQASGRKSQELPQGRKGAAASAWLTATAVVTVLGDPACAFPLRCKPGTGKGLR
FT GERTWPSPRVHGQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_018314"
FT MUTAGEN 38
FT /note="S->A: Abolishes phosphorylation."
FT /evidence="ECO:0000269|PubMed:16820875"
FT MUTAGEN 67
FT /note="S->A: No effect on phosphorylation."
FT /evidence="ECO:0000269|PubMed:16820875"
FT CONFLICT 72
FT /note="H -> Q (in Ref. 1; CAD10038)"
FT /evidence="ECO:0000305"
FT CONFLICT 133
FT /note="P -> H (in Ref. 3; AAH26346)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 292 AA; 32491 MW; 652F11029F517626 CRC64;
MGNQLDRITH LNYSELPTGD PSGIEKDELR VGVAYFFSDD EEDLDERGQP DKFGVKAPPG
CTPCPESPSR HHHHLLHQLV LNETQFSAFR GQECIFSKVS GGPQGADLSV YAVTALPALC
EPGDLLELLW LQPAPEPPAP APHWAVYVGG GQIIHLHQGE IRQDSLYEAG AANVGRVVNS
WYRYRPLVAE LVVQNACGHL GLKSEEICWT NSESFAAWCR FGKREFKAGG EVPAGTQPPQ
QQYYLKVHLG ENKVHTARFH SLEDLIREKR RIDASGRLRV LQELADLVDD KE
