LRAT2_HUMAN
ID LRAT2_HUMAN Reviewed; 310 AA.
AC Q96KN1;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Protein LRATD2 {ECO:0000305};
DE AltName: Full=Breast cancer membrane protein 101;
DE AltName: Full=LRAT domain-containing 2 {ECO:0000312|HGNC:HGNC:24166};
DE AltName: Full=Protein FAM84B {ECO:0000305};
DE AltName: Full=Protein NSE2;
GN Name=LRATD2 {ECO:0000312|HGNC:HGNC:24166};
GN Synonyms=BCMP101, FAM84B {ECO:0000312|HGNC:HGNC:24166}, NSE2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Hughes P.J., Stanway G.;
RT "A novel NS-containing protein.";
RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=16490593; DOI=10.1016/j.cancergencyto.2005.07.009;
RA Huang X.-P., Rong T.-H., Wang J.-Y., Tang Y.-Q., Li B.-J., Xu D.-R.,
RA Zhao M.-Q., Zhang L.-J., Fang Y., Su X.-D., Liang Q.-W.;
RT "Negative implication of C-MYC as an amplification target in esophageal
RT cancer.";
RL Cancer Genet. Cytogenet. 165:20-24(2006).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- INTERACTION:
CC Q96KN1; Q9BXS5: AP1M1; NbExp=3; IntAct=EBI-9057780, EBI-541426;
CC Q96KN1; O96017: CHEK2; NbExp=3; IntAct=EBI-9057780, EBI-1180783;
CC Q96KN1; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-9057780, EBI-742054;
CC Q96KN1; Q06609: RAD51; NbExp=4; IntAct=EBI-9057780, EBI-297202;
CC Q96KN1; Q86VP1: TAX1BP1; NbExp=3; IntAct=EBI-9057780, EBI-529518;
CC Q96KN1; P06132: UROD; NbExp=7; IntAct=EBI-9057780, EBI-2871776;
CC -!- TISSUE SPECIFICITY: Expressed in esophageal squamous cell carcinomas.
CC {ECO:0000269|PubMed:16490593}.
CC -!- SIMILARITY: Belongs to the LRATD family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ417849; CAD10629.1; -; mRNA.
DR EMBL; BC052957; AAH52957.1; -; mRNA.
DR CCDS; CCDS6358.1; -.
DR RefSeq; NP_777571.1; NM_174911.4.
DR RefSeq; XP_016868596.1; XM_017013107.1.
DR AlphaFoldDB; Q96KN1; -.
DR SMR; Q96KN1; -.
DR BioGRID; 127609; 30.
DR IntAct; Q96KN1; 19.
DR MINT; Q96KN1; -.
DR STRING; 9606.ENSP00000302578; -.
DR iPTMnet; Q96KN1; -.
DR PhosphoSitePlus; Q96KN1; -.
DR BioMuta; FAM84B; -.
DR DMDM; 74732219; -.
DR EPD; Q96KN1; -.
DR jPOST; Q96KN1; -.
DR MassIVE; Q96KN1; -.
DR MaxQB; Q96KN1; -.
DR PaxDb; Q96KN1; -.
DR PeptideAtlas; Q96KN1; -.
DR PRIDE; Q96KN1; -.
DR ProteomicsDB; 77084; -.
DR Antibodypedia; 43130; 334 antibodies from 24 providers.
DR DNASU; 157638; -.
DR Ensembl; ENST00000304916.4; ENSP00000302578.3; ENSG00000168672.4.
DR Ensembl; ENST00000652209.1; ENSP00000498944.1; ENSG00000168672.4.
DR GeneID; 157638; -.
DR KEGG; hsa:157638; -.
DR MANE-Select; ENST00000304916.4; ENSP00000302578.3; NM_174911.5; NP_777571.1.
DR UCSC; uc003yrz.3; human.
DR CTD; 157638; -.
DR DisGeNET; 157638; -.
DR GeneCards; LRATD2; -.
DR HGNC; HGNC:24166; LRATD2.
DR HPA; ENSG00000168672; Tissue enhanced (salivary).
DR MIM; 609483; gene.
DR neXtProt; NX_Q96KN1; -.
DR OpenTargets; ENSG00000168672; -.
DR PharmGKB; PA142671855; -.
DR VEuPathDB; HostDB:ENSG00000168672; -.
DR eggNOG; ENOG502QSKN; Eukaryota.
DR GeneTree; ENSGT00940000159198; -.
DR HOGENOM; CLU_082142_0_0_1; -.
DR InParanoid; Q96KN1; -.
DR OMA; MGNQMDK; -.
DR OrthoDB; 953643at2759; -.
DR PhylomeDB; Q96KN1; -.
DR TreeFam; TF330836; -.
DR PathwayCommons; Q96KN1; -.
DR SignaLink; Q96KN1; -.
DR BioGRID-ORCS; 157638; 21 hits in 1068 CRISPR screens.
DR ChiTaRS; FAM84B; human.
DR GenomeRNAi; 157638; -.
DR Pharos; Q96KN1; Tbio.
DR PRO; PR:Q96KN1; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q96KN1; protein.
DR Bgee; ENSG00000168672; Expressed in parotid gland and 181 other tissues.
DR Genevisible; Q96KN1; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:HGNC-UCL.
DR GO; GO:0005886; C:plasma membrane; IDA:HGNC-UCL.
DR InterPro; IPR007053; LRAT_dom.
DR InterPro; IPR043299; LRATD1_LRATD2.
DR InterPro; IPR028815; LRATD2.
DR PANTHER; PTHR46341; PTHR46341; 1.
DR PANTHER; PTHR46341:SF2; PTHR46341:SF2; 1.
DR Pfam; PF04970; LRAT; 1.
DR PROSITE; PS51934; LRAT; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..310
FT /note="Protein LRATD2"
FT /id="PRO_0000234348"
FT DOMAIN 122..217
FT /note="LRAT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01283"
FT REGION 1..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..75
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 310 AA; 34474 MW; B587A33F9CB41938 CRC64;
MGNQVEKLTH LSYKEVPTAD PTGVDRDDGP RIGVSYIFSN DDEDVEPQPP PQGPDGGGLP
DGGDGPPPPQ PQPYDPRLHE VECSVFYRDE CIYQKSFAPG SAALSTYTPE NLLNKCKPGD
LVEFVSQAQY PHWAVYVGNF QVVHLHRLEV INSFLTDASQ GRRGRVVNDL YRYKPLSSSA
VVRNALAHVG AKERELSWRN SESFAAWCRY GKREFKIGGE LRIGKQPYRL QIQLSAQRSH
TLEFQSLEDL IMEKRRNDQI GRAAVLQELA THLHPAEPEE GDSNVARTTP PPGRPPAPSS
EEEDGEAVAH
