LRC10_HUMAN
ID LRC10_HUMAN Reviewed; 277 AA.
AC Q5BKY1; Q6ZVY4;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Leucine-rich repeat-containing protein 10;
GN Name=LRRC10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pericardium;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play important roles in cardiac development and/or
CC cardiac function. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC85724.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK123908; BAC85724.1; ALT_INIT; mRNA.
DR EMBL; BC090881; AAH90881.1; -; mRNA.
DR CCDS; CCDS31856.1; -.
DR RefSeq; NP_963844.2; NM_201550.3.
DR AlphaFoldDB; Q5BKY1; -.
DR SMR; Q5BKY1; -.
DR BioGRID; 132004; 38.
DR IntAct; Q5BKY1; 6.
DR STRING; 9606.ENSP00000355166; -.
DR iPTMnet; Q5BKY1; -.
DR PhosphoSitePlus; Q5BKY1; -.
DR BioMuta; LRRC10; -.
DR DMDM; 74762168; -.
DR MassIVE; Q5BKY1; -.
DR PaxDb; Q5BKY1; -.
DR PeptideAtlas; Q5BKY1; -.
DR PRIDE; Q5BKY1; -.
DR ProteomicsDB; 62709; -.
DR Antibodypedia; 44319; 51 antibodies from 13 providers.
DR DNASU; 376132; -.
DR Ensembl; ENST00000361484.5; ENSP00000355166.3; ENSG00000198812.5.
DR GeneID; 376132; -.
DR KEGG; hsa:376132; -.
DR MANE-Select; ENST00000361484.5; ENSP00000355166.3; NM_201550.4; NP_963844.2.
DR UCSC; uc001svc.4; human.
DR CTD; 376132; -.
DR DisGeNET; 376132; -.
DR GeneCards; LRRC10; -.
DR HGNC; HGNC:20264; LRRC10.
DR HPA; ENSG00000198812; Tissue enriched (heart).
DR MIM; 610846; gene.
DR neXtProt; NX_Q5BKY1; -.
DR OpenTargets; ENSG00000198812; -.
DR PharmGKB; PA134896853; -.
DR VEuPathDB; HostDB:ENSG00000198812; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000155040; -.
DR HOGENOM; CLU_000288_18_15_1; -.
DR InParanoid; Q5BKY1; -.
DR OMA; RNSIRYF; -.
DR OrthoDB; 987531at2759; -.
DR PhylomeDB; Q5BKY1; -.
DR TreeFam; TF332853; -.
DR PathwayCommons; Q5BKY1; -.
DR SignaLink; Q5BKY1; -.
DR BioGRID-ORCS; 376132; 9 hits in 1068 CRISPR screens.
DR GenomeRNAi; 376132; -.
DR Pharos; Q5BKY1; Tdark.
DR PRO; PR:Q5BKY1; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q5BKY1; protein.
DR Bgee; ENSG00000198812; Expressed in apex of heart and 9 other tissues.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030017; C:sarcomere; IBA:GO_Central.
DR GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR GO; GO:0051393; F:alpha-actinin binding; IEA:Ensembl.
DR GO; GO:0055013; P:cardiac muscle cell development; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR PROSITE; PS51450; LRR; 7.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..277
FT /note="Leucine-rich repeat-containing protein 10"
FT /id="PRO_0000084470"
FT REPEAT 53..74
FT /note="LRR 1"
FT REPEAT 76..97
FT /note="LRR 2"
FT REPEAT 99..120
FT /note="LRR 3"
FT REPEAT 122..143
FT /note="LRR 4"
FT REPEAT 145..167
FT /note="LRR 5"
FT REPEAT 168..189
FT /note="LRR 6"
FT REPEAT 191..212
FT /note="LRR 7"
SQ SEQUENCE 277 AA; 31642 MW; 95F326D838980589 CRC64;
MGNTIRALVA FIPADRCQNY VVRDLREMPL DKMVDLSGSQ LRRFPLHVCS FRELVKLYLS
DNHLNSLPPE LGQLQNLQIL ALDFNNFKAL PQVVCTLKQL CILYLGNNKL CDLPSELSLL
QNLRTLWIEA NCLTQLPDVV CELSLLKTLH AGSNALRLLP GQLRRLQELR TIWLSGNRLT
DFPTVLLHMP FLEVIDVDWN SIRYFPSLAH LSSLKLVIYD HNPCRNAPKV AKGVRRVGRW
AEETPEPDPR KARRYALVRE ESQELQAPVP LLPPTNS
