LRC10_MOUSE
ID LRC10_MOUSE Reviewed; 274 AA.
AC Q8K3W2; Q8BUL2;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Leucine-rich repeat-containing protein 10;
DE AltName: Full=Heart-restricted leucine-rich repeat protein;
GN Name=Lrrc10; Synonyms=Hrlrrp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Heart;
RA Chen X.G., Li Y., Zhao R.-B., Pei X.-R., Zang M.-X., Fang L.-F., Chen J.;
RT "Molecular cloning, characterization and expression of Lrrc10, a novel
RT mouse heart specific member of leucine rich repeat superfamily.";
RL Sheng Wu Hua Xue Yu Sheng Wu Wu Li Jin Zhan 30:617-622(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Embryo;
RX PubMed=14751244; DOI=10.1016/j.bbrc.2003.12.202;
RA Nakane T., Satoh T., Inada Y., Nakayama J., Itoh F., Chiba S.;
RT "Molecular cloning and expression of HRLRRP, a novel heart-restricted
RT leucine-rich repeat protein.";
RL Biochem. Biophys. Res. Commun. 314:1086-1092(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play important roles in cardiac development and/or
CC cardiac function.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14751244}.
CC -!- TISSUE SPECIFICITY: Detected specifically in the heart.
CC {ECO:0000269|PubMed:14751244}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF527781; AAM89260.1; -; mRNA.
DR EMBL; AB091100; BAC57985.1; -; mRNA.
DR EMBL; AK084466; BAC39192.1; -; mRNA.
DR EMBL; AK085779; BAC39536.1; -; mRNA.
DR EMBL; BC086911; AAH86911.1; -; mRNA.
DR CCDS; CCDS24189.1; -.
DR RefSeq; NP_666354.1; NM_146242.2.
DR AlphaFoldDB; Q8K3W2; -.
DR SMR; Q8K3W2; -.
DR IntAct; Q8K3W2; 2.
DR STRING; 10090.ENSMUSP00000073502; -.
DR iPTMnet; Q8K3W2; -.
DR PhosphoSitePlus; Q8K3W2; -.
DR PaxDb; Q8K3W2; -.
DR PRIDE; Q8K3W2; -.
DR ProteomicsDB; 290148; -.
DR Antibodypedia; 44319; 51 antibodies from 13 providers.
DR DNASU; 237560; -.
DR Ensembl; ENSMUST00000073834; ENSMUSP00000073502; ENSMUSG00000060187.
DR GeneID; 237560; -.
DR KEGG; mmu:237560; -.
DR UCSC; uc007hcr.1; mouse.
DR CTD; 376132; -.
DR MGI; MGI:2448063; Lrrc10.
DR VEuPathDB; HostDB:ENSMUSG00000060187; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000155040; -.
DR HOGENOM; CLU_000288_18_15_1; -.
DR InParanoid; Q8K3W2; -.
DR OMA; RNSIRYF; -.
DR OrthoDB; 987531at2759; -.
DR PhylomeDB; Q8K3W2; -.
DR TreeFam; TF332853; -.
DR BioGRID-ORCS; 237560; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q8K3W2; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8K3W2; protein.
DR Bgee; ENSMUSG00000060187; Expressed in heart and 14 other tissues.
DR GO; GO:0005856; C:cytoskeleton; IDA:MGI.
DR GO; GO:0005739; C:mitochondrion; IDA:MGI.
DR GO; GO:0030016; C:myofibril; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0030017; C:sarcomere; IDA:MGI.
DR GO; GO:0003779; F:actin binding; IDA:MGI.
DR GO; GO:0051393; F:alpha-actinin binding; IDA:MGI.
DR GO; GO:0055013; P:cardiac muscle cell development; IMP:MGI.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 5.
DR PROSITE; PS51450; LRR; 7.
PE 1: Evidence at protein level;
KW Leucine-rich repeat; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..274
FT /note="Leucine-rich repeat-containing protein 10"
FT /id="PRO_0000084471"
FT REPEAT 30..51
FT /note="LRR 1"
FT REPEAT 52..74
FT /note="LRR 2"
FT REPEAT 76..97
FT /note="LRR 3"
FT REPEAT 98..120
FT /note="LRR 4"
FT REPEAT 121..143
FT /note="LRR 5"
FT REPEAT 145..166
FT /note="LRR 6"
FT REPEAT 167..189
FT /note="LRR 7"
FT REPEAT 191..213
FT /note="LRR 8"
FT REGION 236..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..260
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 26
FT /note="R -> Q (in Ref. 3; BAC39192)"
FT /evidence="ECO:0000305"
FT CONFLICT 75
FT /note="Q -> R (in Ref. 3; BAC39192)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 274 AA; 31263 MW; 826B76D4FA4EDDD0 CRC64;
MGNTIRAFVA FIPTDRCQSY VVGDLREMPL DRMVDLSGSQ LRRFPLHVCS FTELVKLYLS
DNHLHSLPPD LAQLQNLQIL ALDFNNFKAL PRVVCTLKQL CILYLGNNKL CDLPDELSLL
QNLRTLWLES NCLTRLPDVV CELSLLKTLH AGSNALRLLP GQLRRLRELR TIWLSGNQLA
DFPSVLLRMP FLEVIDVDRN SIRYFPSLAH LTNLKLVIYD HNPCRNAPKV GKGVRRVGRW
AEETPEPDPR KARRYALAKE ENQEPPPPLL PSSS
