ID   LRC14_BOVIN             Reviewed;         493 AA.
AC   A5PJJ5;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Leucine-rich repeat-containing protein 14 {ECO:0000250|UniProtKB:Q15048};
GN   Name=LRRC14 {ECO:0000250|UniProtKB:Q15048};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negatively regulates Toll-like receptor-mediated NF-kappa-B
CC       signaling by disrupting IKK core complex formation through interaction
CC       with IKBKB. {ECO:0000250|UniProtKB:Q15048}.
CC   -!- SUBUNIT: Interacts with IKBKB; disrupts IKBKB-IKBKG interaction
CC       preventing I-kappa-B-kinase (IKK) core complex formation and leading to
CC       a decrease of IKBKB phosphorylation and NF-kappaB activation. Interacts
CC       with CHUK. {ECO:0000250|UniProtKB:Q15048}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q15048}.
CC   -!- SIMILARITY: Belongs to the PRAME family. LRRC14 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC142136; AAI42137.1; -; mRNA.
DR   RefSeq; NP_001095849.1; NM_001102379.1.
DR   RefSeq; XP_015329847.1; XM_015474361.1.
DR   RefSeq; XP_015329848.1; XM_015474362.1.
DR   RefSeq; XP_015329849.1; XM_015474363.1.
DR   AlphaFoldDB; A5PJJ5; -.
DR   STRING; 9913.ENSBTAP00000006542; -.
DR   PaxDb; A5PJJ5; -.
DR   PRIDE; A5PJJ5; -.
DR   Ensembl; ENSBTAT00000006542; ENSBTAP00000006542; ENSBTAG00000004969.
DR   Ensembl; ENSBTAT00000083761; ENSBTAP00000060875; ENSBTAG00000004969.
DR   GeneID; 539952; -.
DR   KEGG; bta:539952; -.
DR   CTD; 9684; -.
DR   VEuPathDB; HostDB:ENSBTAG00000004969; -.
DR   VGNC; VGNC:30999; LRRC14.
DR   eggNOG; ENOG502QWSJ; Eukaryota.
DR   GeneTree; ENSGT01030000234531; -.
DR   HOGENOM; CLU_039635_0_1_1; -.
DR   InParanoid; A5PJJ5; -.
DR   OMA; VTECELM; -.
DR   OrthoDB; 563553at2759; -.
DR   TreeFam; TF332708; -.
DR   Proteomes; UP000009136; Chromosome 14.
DR   Bgee; ENSBTAG00000004969; Expressed in retina and 104 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0019900; F:kinase binding; IBA:GO_Central.
DR   GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0034122; P:negative regulation of toll-like receptor signaling pathway; ISS:UniProtKB.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR026292; LRRC14.
DR   PANTHER; PTHR14224:SF9; PTHR14224:SF9; 1.
DR   Pfam; PF13516; LRR_6; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..493
FT                   /note="Leucine-rich repeat-containing protein 14"
FT                   /id="PRO_0000343680"
FT   REPEAT          111..146
FT                   /note="LRR 1; degenerate"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          194..218
FT                   /note="LRR 2; degenerate"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          219..246
FT                   /note="LRR 3; degenerate"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          247..282
FT                   /note="LRR 4; degenerate"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          283..307
FT                   /note="LRR 5"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          308..339
FT                   /note="LRR 6"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          340..360
FT                   /note="LRR 7"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          364..391
FT                   /note="LRR 8"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          392..416
FT                   /note="LRR 9"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
SQ   SEQUENCE   493 AA;  54918 MW;  9DA2857016814323 CRC64;
     MHTLVFLSTR QVLQCQSAAC QALPLLPREL FPLLFKVAFM DKKTVVLREL VHTWPFPLLS
     FQQLLQECAH CSRALLQERP STESMQAVIL GLTARLHTPE TEPGTQPLCR KHTLRVLDMT
     GLLDDGVEQD PGTMSMWDCT AAVARTCIEQ QQGRTAEPGQ APVPVEVRVD LRVNRASYAF
     LREALRSSVG SPLRLCCRDL RAEDLPMRNT VALLQLLDAG CLRRVDLRFN NLGLRGLSVI
     IPHVARFQHL ASLRLHYVHG DSRQPSVDGE DNFRYFLAQM GRFTCLRELS MGSSLLSGRL
     DQLLSTLQSP LESLELAFCA LLPEDLRFLA RSSHAVHLKK LDLSGNDLSG SQLEPFQGLL
     QAAAATLLHL ELTECQLADT QLLATLPVLT RCASLRYLGL YGNPLSVAGL RELLRDSVVQ
     AELRTVVHPF PVDCYEGLPW PPPASVLLEA SINEEKFARV EAELHQLLLA SGRAHVLWTT
     DIYGRLAADY FSL