LRC15_HUMAN
ID LRC15_HUMAN Reviewed; 581 AA.
AC Q8TF66; Q495Q6; Q7RTN7;
DT 09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 31-MAY-2011, sequence version 2.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Leucine-rich repeat-containing protein 15;
DE AltName: Full=Leucine-rich repeat protein induced by beta-amyloid homolog;
DE Short=hLib;
DE Flags: Precursor;
GN Name=LRRC15; Synonyms=LIB;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS ILE-264 AND LEU-286.
RC TISSUE=Brain;
RX PubMed=11785964; DOI=10.1006/bbrc.2001.6272;
RA Satoh K., Hata M., Yokota H.;
RT "A novel member of the leucine-rich repeat superfamily induced in rat
RT astrocytes by beta-amyloid.";
RL Biochem. Biophys. Res. Commun. 290:756-762(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION, ALTERNATIVE SPLICING (ISOFORM 2), AND VARIANTS ILE-264 AND
RP LEU-286.
RX PubMed=12923058; DOI=10.1101/gad.1110703;
RA Reynolds P.A., Smolen G.A., Palmer R.E., Sgroi D., Yajnik V., Gerald W.L.,
RA Haber D.A.;
RT "Identification of a DNA-binding site and transcriptional target for the
RT EWS-WT1(+KTS) oncoprotein.";
RL Genes Dev. 17:2094-2107(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8TF66-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TF66-2; Sequence=VSP_041130;
CC -!- TISSUE SPECIFICITY: Brain and placenta.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI01065.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=DAA01740.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB071037; BAB84587.1; -; mRNA.
DR EMBL; AC125362; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC174158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW78054.1; -; Genomic_DNA.
DR EMBL; BC101064; AAI01065.1; ALT_INIT; mRNA.
DR EMBL; BC101065; AAI01066.1; -; mRNA.
DR EMBL; BK001325; DAA01740.1; ALT_INIT; mRNA.
DR CCDS; CCDS3306.1; -. [Q8TF66-1]
DR CCDS; CCDS46984.1; -. [Q8TF66-2]
DR RefSeq; NP_001128529.2; NM_001135057.2. [Q8TF66-2]
DR RefSeq; NP_570843.2; NM_130830.4. [Q8TF66-1]
DR AlphaFoldDB; Q8TF66; -.
DR SMR; Q8TF66; -.
DR BioGRID; 126287; 194.
DR IntAct; Q8TF66; 48.
DR MINT; Q8TF66; -.
DR STRING; 9606.ENSP00000413707; -.
DR ChEMBL; CHEMBL4295907; -.
DR TCDB; 8.A.43.1.13; the neat-domain containing methaemoglobin heme sequestration (n-mhs) family.
DR GlyConnect; 1451; 3 N-Linked glycans (1 site).
DR GlyGen; Q8TF66; 2 sites, 3 N-linked glycans (1 site).
DR iPTMnet; Q8TF66; -.
DR PhosphoSitePlus; Q8TF66; -.
DR SwissPalm; Q8TF66; -.
DR BioMuta; LRRC15; -.
DR DMDM; 334302830; -.
DR EPD; Q8TF66; -.
DR jPOST; Q8TF66; -.
DR MassIVE; Q8TF66; -.
DR MaxQB; Q8TF66; -.
DR PaxDb; Q8TF66; -.
DR PeptideAtlas; Q8TF66; -.
DR PRIDE; Q8TF66; -.
DR ProteomicsDB; 74566; -. [Q8TF66-1]
DR ProteomicsDB; 74567; -. [Q8TF66-2]
DR ABCD; Q8TF66; 1 sequenced antibody.
DR Antibodypedia; 33889; 121 antibodies from 19 providers.
DR DNASU; 131578; -.
DR Ensembl; ENST00000347624.4; ENSP00000306276.4; ENSG00000172061.9. [Q8TF66-1]
DR Ensembl; ENST00000428839.1; ENSP00000413707.1; ENSG00000172061.9. [Q8TF66-2]
DR GeneID; 131578; -.
DR KEGG; hsa:131578; -.
DR MANE-Select; ENST00000347624.4; ENSP00000306276.4; NM_130830.5; NP_570843.2.
DR UCSC; uc003ftt.4; human. [Q8TF66-1]
DR CTD; 131578; -.
DR DisGeNET; 131578; -.
DR GeneCards; LRRC15; -.
DR HGNC; HGNC:20818; LRRC15.
DR HPA; ENSG00000172061; Tissue enhanced (lymphoid tissue, skin).
DR MIM; 619327; gene.
DR neXtProt; NX_Q8TF66; -.
DR OpenTargets; ENSG00000172061; -.
DR PharmGKB; PA134956867; -.
DR VEuPathDB; HostDB:ENSG00000172061; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000161771; -.
DR HOGENOM; CLU_000288_18_6_1; -.
DR InParanoid; Q8TF66; -.
DR OrthoDB; 826997at2759; -.
DR TreeFam; TF351124; -.
DR PathwayCommons; Q8TF66; -.
DR SignaLink; Q8TF66; -.
DR BioGRID-ORCS; 131578; 33 hits in 1062 CRISPR screens.
DR ChiTaRS; LRRC15; human.
DR GenomeRNAi; 131578; -.
DR Pharos; Q8TF66; Tbio.
DR PRO; PR:Q8TF66; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8TF66; protein.
DR Bgee; ENSG00000172061; Expressed in periodontal ligament and 98 other tissues.
DR Genevisible; Q8TF66; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005518; F:collagen binding; IDA:UniProtKB.
DR GO; GO:0001968; F:fibronectin binding; IDA:UniProtKB.
DR GO; GO:0043236; F:laminin binding; IDA:UniProtKB.
DR GO; GO:1903077; P:negative regulation of protein localization to plasma membrane; IMP:UniProtKB.
DR GO; GO:0030335; P:positive regulation of cell migration; IMP:UniProtKB.
DR GO; GO:0046813; P:receptor-mediated virion attachment to host cell; IMP:UniProtKB.
DR Gene3D; 3.80.10.10; -; 4.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF00560; LRR_1; 2.
DR Pfam; PF13855; LRR_8; 4.
DR SMART; SM00369; LRR_TYP; 14.
DR SMART; SM00082; LRRCT; 1.
DR PROSITE; PS51450; LRR; 14.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Leucine-rich repeat; Membrane;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..581
FT /note="Leucine-rich repeat-containing protein 15"
FT /id="PRO_0000021605"
FT TOPO_DOM 22..538
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 539..559
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 560..581
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 22..53
FT /note="LRRNT"
FT REPEAT 54..75
FT /note="LRR 1"
FT REPEAT 78..99
FT /note="LRR 2"
FT REPEAT 102..123
FT /note="LRR 3"
FT REPEAT 126..147
FT /note="LRR 4"
FT REPEAT 150..171
FT /note="LRR 5"
FT REPEAT 174..195
FT /note="LRR 6"
FT REPEAT 198..219
FT /note="LRR 7"
FT REPEAT 222..243
FT /note="LRR 8"
FT REPEAT 246..267
FT /note="LRR 9"
FT REPEAT 270..291
FT /note="LRR 10"
FT REPEAT 294..315
FT /note="LRR 11"
FT REPEAT 318..339
FT /note="LRR 12"
FT REPEAT 342..363
FT /note="LRR 13"
FT REPEAT 366..387
FT /note="LRR 14"
FT REPEAT 390..411
FT /note="LRR 15"
FT DOMAIN 423..475
FT /note="LRRCT"
FT REGION 489..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 75
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 369
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1
FT /note="M -> MPLDKAM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_041130"
FT VARIANT 264
FT /note="V -> I (in dbSNP:rs13060627)"
FT /evidence="ECO:0000269|PubMed:11785964,
FT ECO:0000269|PubMed:12923058"
FT /id="VAR_051101"
FT VARIANT 286
FT /note="P -> L (in dbSNP:rs13070515)"
FT /evidence="ECO:0000269|PubMed:11785964,
FT ECO:0000269|PubMed:12923058"
FT /id="VAR_051102"
SQ SEQUENCE 581 AA; 64366 MW; 1CA7B1752C7FE5B3 CRC64;
MPLKHYLLLL VGCQAWGAGL AYHGCPSECT CSRASQVECT GARIVAVPTP LPWNAMSLQI
LNTHITELNE SPFLNISALI ALRIEKNELS RITPGAFRNL GSLRYLSLAN NKLQVLPIGL
FQGLDSLESL LLSSNQLLQI QPAHFSQCSN LKELQLHGNH LEYIPDGAFD HLVGLTKLNL
GKNSLTHISP RVFQHLGNLQ VLRLYENRLT DIPMGTFDGL VNLQELALQQ NQIGLLSPGL
FHNNHNLQRL YLSNNHISQL PPSVFMQLPQ LNRLTLFGNS LKELSPGIFG PMPNLRELWL
YDNHISSLPD NVFSNLRQLQ VLILSRNQIS FISPGAFNGL TELRELSLHT NALQDLDGNV
FRMLANLQNI SLQNNRLRQL PGNIFANVNG LMAIQLQNNQ LENLPLGIFD HLGKLCELRL
YDNPWRCDSD ILPLRNWLLL NQPRLGTDTV PVCFSPANVR GQSLIIINVN VAVPSVHVPE
VPSYPETPWY PDTPSYPDTT SVSSTTELTS PVEDYTDLTT IQVTDDRSVW GMTQAQSGLA
IAAIVIGIVA LACSLAACVG CCCCKKRSQA VLMQMKAPNE C
