LRC15_MOUSE
ID LRC15_MOUSE Reviewed; 579 AA.
AC Q80X72;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Leucine-rich repeat-containing protein 15;
DE Flags: Precursor;
GN Name=Lrrc15;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; BC050245; AAH50245.1; -; mRNA.
DR CCDS; CCDS28099.1; -.
DR RefSeq; NP_083249.1; NM_028973.2.
DR AlphaFoldDB; Q80X72; -.
DR SMR; Q80X72; -.
DR BioGRID; 216793; 1.
DR IntAct; Q80X72; 1.
DR STRING; 10090.ENSMUSP00000066777; -.
DR GlyGen; Q80X72; 2 sites.
DR PhosphoSitePlus; Q80X72; -.
DR MaxQB; Q80X72; -.
DR PaxDb; Q80X72; -.
DR PeptideAtlas; Q80X72; -.
DR PRIDE; Q80X72; -.
DR ProteomicsDB; 252504; -.
DR Antibodypedia; 33889; 121 antibodies from 19 providers.
DR DNASU; 74488; -.
DR Ensembl; ENSMUST00000064606; ENSMUSP00000066777; ENSMUSG00000052316.
DR GeneID; 74488; -.
DR KEGG; mmu:74488; -.
DR UCSC; uc007ywn.2; mouse.
DR CTD; 131578; -.
DR MGI; MGI:1921738; Lrrc15.
DR VEuPathDB; HostDB:ENSMUSG00000052316; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000161771; -.
DR HOGENOM; CLU_000288_18_6_1; -.
DR InParanoid; Q80X72; -.
DR OMA; HNNSWRC; -.
DR OrthoDB; 826997at2759; -.
DR PhylomeDB; Q80X72; -.
DR TreeFam; TF351124; -.
DR BioGRID-ORCS; 74488; 4 hits in 72 CRISPR screens.
DR PRO; PR:Q80X72; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q80X72; protein.
DR Bgee; ENSMUSG00000052316; Expressed in lip and 48 other tissues.
DR Genevisible; Q80X72; MM.
DR GO; GO:0009986; C:cell surface; ISO:MGI.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; ISO:MGI.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005518; F:collagen binding; ISO:MGI.
DR GO; GO:0001968; F:fibronectin binding; ISO:MGI.
DR GO; GO:0043236; F:laminin binding; ISO:MGI.
DR GO; GO:1903077; P:negative regulation of protein localization to plasma membrane; ISO:MGI.
DR GO; GO:0030335; P:positive regulation of cell migration; ISO:MGI.
DR GO; GO:0046813; P:receptor-mediated virion attachment to host cell; ISO:MGI.
DR Gene3D; 3.80.10.10; -; 3.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 5.
DR SMART; SM00369; LRR_TYP; 14.
DR SMART; SM00082; LRRCT; 1.
DR PROSITE; PS51450; LRR; 14.
PE 2: Evidence at transcript level;
KW Glycoprotein; Leucine-rich repeat; Membrane; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..579
FT /note="Leucine-rich repeat-containing protein 15"
FT /id="PRO_0000021606"
FT TOPO_DOM 22..536
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 537..557
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 558..579
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 22..53
FT /note="LRRNT"
FT REPEAT 54..75
FT /note="LRR 1"
FT REPEAT 78..99
FT /note="LRR 2"
FT REPEAT 102..123
FT /note="LRR 3"
FT REPEAT 126..147
FT /note="LRR 4"
FT REPEAT 150..171
FT /note="LRR 5"
FT REPEAT 174..195
FT /note="LRR 6"
FT REPEAT 198..219
FT /note="LRR 7"
FT REPEAT 222..243
FT /note="LRR 8"
FT REPEAT 246..267
FT /note="LRR 9"
FT REPEAT 270..291
FT /note="LRR 10"
FT REPEAT 294..315
FT /note="LRR 11"
FT REPEAT 318..339
FT /note="LRR 12"
FT REPEAT 342..363
FT /note="LRR 13"
FT REPEAT 366..387
FT /note="LRR 14"
FT REPEAT 390..411
FT /note="LRR 15"
FT DOMAIN 423..473
FT /note="LRRCT"
FT REGION 476..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 75
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 369
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 579 AA; 64177 MW; 7841957F6FB643D3 CRC64;
MPLKHYLLLL VSCQAWAAGL AYYGCPSECT CSRASQVECT GAQIVAMPSP LPWNAMSLQI
LNTHITELPE DKFLNISALI ALKMEKNELA NIMPGAFRNL GSLRHLSLAN NKLKNLPVRL
FQDVNNLETL LLSNNQLVQI QPAQFSQFSN LKELQLYGNN LEYIPEGVFD HLVGLTKLNL
GNNGFTHLSP RVFQHLGNLQ VLRLYENRLS DIPMGTFDAL GNLQELALQE NQIGTLSPGL
FHNNRNLQRL YLSNNHISHL PPGIFMQLPH LNKLTLFGNS LKELSPGVFG PMPNLRELWL
YNNHITSLPD NAFSHLNQLQ VLILSHNQLS YISPGAFNGL TNLRELSLHT NALQDLDGNV
FRSLANLRNV SLQNNRLRQL PGSIFANVNG LMTIQLQNNN LENLPLGIFD HLGNLCELRL
YDNPWRCDSN ILPLHDWLIL NRARLGTDTL PVCSSPASVR GQSLVIINVN FPGPSVQGPE
TPEVSSYPDT SSYPDSTSIS STTEITRSTD DDYTDLNTIE PIDDRNTWGM TDAQSGLAIA
AIVIGIIALA CSLAACICCC CCKKRSQAVL MQMKAPNEC
