ID   LRC15_RAT               Reviewed;         578 AA.
AC   Q8R5M3;
DT   09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Leucine-rich repeat-containing protein 15;
DE   AltName: Full=Leucine-rich repeat protein induced by amyloid-beta;
DE            Short=rLib;
DE   Flags: Precursor;
GN   Name=Lrrc15; Synonyms=Lib;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar; TISSUE=Fetal brain;
RX   PubMed=11785964; DOI=10.1006/bbrc.2001.6272;
RA   Satoh K., Hata M., Yokota H.;
RT   "A novel member of the leucine-rich repeat superfamily induced in rat
RT   astrocytes by beta-amyloid.";
RL   Biochem. Biophys. Res. Commun. 290:756-762(2002).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- INDUCTION: By amyloid-beta.
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DR   EMBL; AB071036; BAB84586.1; -; mRNA.
DR   RefSeq; NP_659551.1; NM_145083.1.
DR   AlphaFoldDB; Q8R5M3; -.
DR   SMR; Q8R5M3; -.
DR   STRING; 10116.ENSRNOP00000064155; -.
DR   GlyGen; Q8R5M3; 2 sites.
DR   PaxDb; Q8R5M3; -.
DR   PRIDE; Q8R5M3; -.
DR   GeneID; 246296; -.
DR   KEGG; rno:246296; -.
DR   UCSC; RGD:70551; rat.
DR   CTD; 131578; -.
DR   RGD; 70551; Lrrc15.
DR   eggNOG; KOG0619; Eukaryota.
DR   InParanoid; Q8R5M3; -.
DR   OrthoDB; 826997at2759; -.
DR   PhylomeDB; Q8R5M3; -.
DR   PRO; PR:Q8R5M3; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0009986; C:cell surface; IDA:RGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005518; F:collagen binding; ISO:RGD.
DR   GO; GO:0001968; F:fibronectin binding; ISO:RGD.
DR   GO; GO:0043236; F:laminin binding; ISO:RGD.
DR   GO; GO:1903077; P:negative regulation of protein localization to plasma membrane; ISO:RGD.
DR   GO; GO:0030335; P:positive regulation of cell migration; ISO:RGD.
DR   GO; GO:0046813; P:receptor-mediated virion attachment to host cell; ISO:RGD.
DR   Gene3D; 3.80.10.10; -; 4.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF00560; LRR_1; 2.
DR   Pfam; PF13855; LRR_8; 4.
DR   SMART; SM00369; LRR_TYP; 14.
DR   SMART; SM00082; LRRCT; 1.
DR   PROSITE; PS51450; LRR; 14.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Leucine-rich repeat; Membrane; Reference proteome; Repeat;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..578
FT                   /note="Leucine-rich repeat-containing protein 15"
FT                   /id="PRO_0000021607"
FT   TOPO_DOM        22..535
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        536..556
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        557..578
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          22..53
FT                   /note="LRRNT"
FT   REPEAT          54..75
FT                   /note="LRR 1"
FT   REPEAT          78..99
FT                   /note="LRR 2"
FT   REPEAT          102..123
FT                   /note="LRR 3"
FT   REPEAT          126..147
FT                   /note="LRR 4"
FT   REPEAT          150..171
FT                   /note="LRR 5"
FT   REPEAT          174..195
FT                   /note="LRR 6"
FT   REPEAT          198..219
FT                   /note="LRR 7"
FT   REPEAT          222..243
FT                   /note="LRR 8"
FT   REPEAT          246..267
FT                   /note="LRR 9"
FT   REPEAT          270..291
FT                   /note="LRR 10"
FT   REPEAT          294..315
FT                   /note="LRR 11"
FT   REPEAT          318..339
FT                   /note="LRR 12"
FT   REPEAT          342..363
FT                   /note="LRR 13"
FT   REPEAT          366..387
FT                   /note="LRR 14"
FT   REPEAT          390..411
FT                   /note="LRR 15"
FT   DOMAIN          423..473
FT                   /note="LRRCT"
FT   REGION          476..500
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        75
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        369
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   578 AA;  64128 MW;  991BD057F5912591 CRC64;
     MPLKHYLLLL VGCQAWALGL AYYGCPSECT CSRASQVECT GARIVAMPTP LPWNAMSLQV
     VNTHITELPE NLFLNISALI ALKMEKNELS TIMPGAFRNL GSLRYLSLAN NKLRMLPIRV
     FQDVNNLESL LLSNNQLVQI QPAQFSQFSN LRELQLHGNN LESIPEEAFD HLVGLTKLNL
     GRNSFTHLSP RLFQHLGNLQ VLRLHENRLS DIPMGTFDAL GNLQELALQE NQIGTLSPGL
     FHNNRNLQRL YLSNNHISQL PPGIFMQLPQ LNKLTLFGNS LRELSPGVFG PMPNLRELWL
     YNNHITSLAD NTFSHLNQLQ VLILSHNQLT YISPGAFNGL TNLRELSLHT NALQDLDSNV
     FRSLANLQNI SLQSNRLRQL PGSIFANVNG LTTIQLQNNN LENLPLGIFD HLVNLCELRL
     YDNPWRCDSD ILPLHNWLLL NRARLGTDTL PVCSSPANVR GQSLVIININ FPGPSVQGPE
     TPEVPSYPDT PSYPDTTSVS STTEITSAVD DYTDLTTIEA TDDRNTWGMT EAQSGLAIAA
     IVIGIIALAC SLAACICCCC CKKRSQAVLM QMKAPNEC