LRC17_MOUSE
ID LRC17_MOUSE Reviewed; 443 AA.
AC Q9CXD9;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Leucine-rich repeat-containing protein 17;
DE Flags: Precursor;
GN Name=Lrrc17;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, INDUCTION, AND TISSUE SPECIFICITY.
RX PubMed=19336404; DOI=10.1074/jbc.m807722200;
RA Kim T., Kim K., Lee S.H., So H.-S., Lee J., Kim N., Choi Y.;
RT "Identification of LRRc17 as a negative regulator of receptor activator of
RT NF-kappaB ligand (RANKL)-induced osteoclast differentiation.";
RL J. Biol. Chem. 284:15308-15316(2009).
CC -!- FUNCTION: Involved in bone homeostasis. Acts as a negative regulator of
CC RANKL-induced osteoclast precursor differentiation from bone marrow
CC precursors. {ECO:0000269|PubMed:19336404}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000269|PubMed:19336404}.
CC -!- TISSUE SPECIFICITY: Expressed in osteoblasts, spleen, lung and heart.
CC {ECO:0000269|PubMed:19336404}.
CC -!- INDUCTION: Down-regulated in osteoblasts in response to pro-
CC osteoclastogenic factors. {ECO:0000269|PubMed:19336404}.
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DR EMBL; AK018071; BAB31060.1; -; mRNA.
DR EMBL; BC030317; AAH30317.1; -; mRNA.
DR CCDS; CCDS51428.1; -.
DR RefSeq; NP_083253.1; NM_028977.1.
DR AlphaFoldDB; Q9CXD9; -.
DR SMR; Q9CXD9; -.
DR STRING; 10090.ENSMUSP00000038569; -.
DR PhosphoSitePlus; Q9CXD9; -.
DR MaxQB; Q9CXD9; -.
DR PaxDb; Q9CXD9; -.
DR PRIDE; Q9CXD9; -.
DR ProteomicsDB; 287261; -.
DR Antibodypedia; 31152; 54 antibodies from 16 providers.
DR Ensembl; ENSMUST00000035651; ENSMUSP00000038569; ENSMUSG00000039883.
DR GeneID; 74511; -.
DR KEGG; mmu:74511; -.
DR UCSC; uc008wor.2; mouse.
DR CTD; 10234; -.
DR MGI; MGI:1921761; Lrrc17.
DR VEuPathDB; HostDB:ENSMUSG00000039883; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000156400; -.
DR HOGENOM; CLU_049990_0_0_1; -.
DR InParanoid; Q9CXD9; -.
DR OMA; FRGWRVE; -.
DR OrthoDB; 282791at2759; -.
DR PhylomeDB; Q9CXD9; -.
DR BioGRID-ORCS; 74511; 6 hits in 72 CRISPR screens.
DR PRO; PR:Q9CXD9; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9CXD9; protein.
DR Bgee; ENSMUSG00000039883; Expressed in humerus cartilage element and 128 other tissues.
DR Genevisible; Q9CXD9; MM.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0048539; P:bone marrow development; IDA:UniProtKB.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; IDA:UniProtKB.
DR GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00369; LRR_TYP; 5.
DR SMART; SM00082; LRRCT; 2.
DR PROSITE; PS51450; LRR; 6.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Osteogenesis; Reference proteome; Repeat; Secreted;
KW Signal.
FT SIGNAL 1..15
FT /evidence="ECO:0000255"
FT CHAIN 16..443
FT /note="Leucine-rich repeat-containing protein 17"
FT /id="PRO_0000021609"
FT REPEAT 84..105
FT /note="LRR 1"
FT REPEAT 108..129
FT /note="LRR 2"
FT REPEAT 132..153
FT /note="LRR 3"
FT DOMAIN 165..216
FT /note="LRRCT 1"
FT DOMAIN 229..270
FT /note="LRRNT"
FT REPEAT 271..292
FT /note="LRR 4"
FT REPEAT 295..316
FT /note="LRR 5"
FT REPEAT 319..342
FT /note="LRR 6"
FT DOMAIN 352..404
FT /note="LRRCT 2"
FT REGION 20..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 443 AA; 51852 MW; CF5C962262BB555E CRC64;
MRIVAILLLF CLCRAAEPRK SSPGVLRSQG NPSRSHGRGG RRGSSPVKRY APGLPCDVYT
YLHEKYLDCQ ERKLVYVLPD WPQDLLHMLL ARNKIRVLKN NMFAKFKRLK SLDLQQNEIS
KIESEAFFGL NKLTTLLLQH NQIKVLTEEA FIYTPLLSYL RLYDNPWHCT CELETLISML
QIPRNRNLGN YAKCGSPPAL RNKKLLQLKP QELCDEEEKE QLDPKPQVSG IPAVIRPEAD
STLCHNYVFP IQTLDCKRKE LKKVPSNIPP DIVKLDLSSN KIRQLRPKEF EDVHELKKLN
LSSNGIEFID PAAFLGLIHL EELDLSNNSL QNFDYGVLED LYFLKLLWLR DNPWRCDYSI
HYLYYWLKHH YNVHYNGLEC KTPEEYKGWS VGKYVRSYYE ECPKDKLPAY PETFDQDTED
DEWQKIHRDH PAKKHRVRIT IVG
