LRC18_MOUSE
ID LRC18_MOUSE Reviewed; 262 AA.
AC Q9CQ07; Q6P8T8; Q80ZT3; Q9CW01; Q9DA89;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Leucine-rich repeat-containing protein 18;
DE AltName: Full=Testis-specific LRR protein;
GN Name=Lrrc18; Synonyms=Mtlr1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION, AND
RP SUBCELLULAR LOCATION.
RX PubMed=15707978; DOI=10.1016/j.bbrc.2005.01.053;
RA Nie D.-S., Xiang Y., Wang J., Deng Y., Tan X.-J., Liang Y.-H., Lu G.-X.;
RT "Identification of a novel testis-specific gene mtLR1, which is expressed
RT at specific stages of mouse spermatogenesis.";
RL Biochem. Biophys. Res. Commun. 328:1010-1018(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in the regulation of spermatogenesis and
CC sperm maturation.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15707978}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9CQ07-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9CQ07-2; Sequence=VSP_015741;
CC -!- TISSUE SPECIFICITY: Exclusively expressed in spermatocytes and roud
CC spermatids within seminiferous tubules during spermatogenesis.
CC {ECO:0000269|PubMed:15707978}.
CC -!- INDUCTION: Up-regulated during sexual maturation and dowm-regulated by
CC experimental cryptorchidism and heat stress.
CC {ECO:0000269|PubMed:15707978}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH48444.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; AY775400; AAV34143.1; -; mRNA.
DR EMBL; AK005666; BAB24176.3; -; mRNA.
DR EMBL; AK006063; BAB24391.1; -; mRNA.
DR EMBL; AK014952; BAB29635.1; -; mRNA.
DR EMBL; AK015365; BAB29814.1; -; mRNA.
DR EMBL; AK029909; BAC26670.1; -; mRNA.
DR EMBL; BC048444; AAH48444.1; ALT_SEQ; mRNA.
DR EMBL; BC061072; AAH61072.1; -; mRNA.
DR CCDS; CCDS26924.1; -. [Q9CQ07-1]
DR CCDS; CCDS49440.1; -. [Q9CQ07-2]
DR RefSeq; NP_001139493.1; NM_001146021.1. [Q9CQ07-2]
DR RefSeq; NP_080529.1; NM_026253.4. [Q9CQ07-1]
DR RefSeq; XP_006519520.1; XM_006519457.3. [Q9CQ07-1]
DR RefSeq; XP_006519521.1; XM_006519458.3. [Q9CQ07-1]
DR AlphaFoldDB; Q9CQ07; -.
DR SMR; Q9CQ07; -.
DR STRING; 10090.ENSMUSP00000041199; -.
DR iPTMnet; Q9CQ07; -.
DR PhosphoSitePlus; Q9CQ07; -.
DR MaxQB; Q9CQ07; -.
DR PaxDb; Q9CQ07; -.
DR PRIDE; Q9CQ07; -.
DR ProteomicsDB; 252665; -. [Q9CQ07-1]
DR ProteomicsDB; 252666; -. [Q9CQ07-2]
DR Antibodypedia; 49932; 101 antibodies from 20 providers.
DR DNASU; 67580; -.
DR Ensembl; ENSMUST00000038956; ENSMUSP00000041199; ENSMUSG00000041673. [Q9CQ07-1]
DR Ensembl; ENSMUST00000120866; ENSMUSP00000113608; ENSMUSG00000041673. [Q9CQ07-2]
DR GeneID; 67580; -.
DR KEGG; mmu:67580; -.
DR UCSC; uc007szl.2; mouse. [Q9CQ07-1]
DR CTD; 474354; -.
DR MGI; MGI:1914830; Lrrc18.
DR VEuPathDB; HostDB:ENSMUSG00000041673; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000156026; -.
DR HOGENOM; CLU_000288_18_15_1; -.
DR InParanoid; Q9CQ07; -.
DR OMA; NFPKCIL; -.
DR OrthoDB; 1059633at2759; -.
DR PhylomeDB; Q9CQ07; -.
DR TreeFam; TF331129; -.
DR BioGRID-ORCS; 67580; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q9CQ07; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q9CQ07; protein.
DR Bgee; ENSMUSG00000041673; Expressed in seminiferous tubule of testis and 40 other tissues.
DR ExpressionAtlas; Q9CQ07; baseline and differential.
DR Genevisible; Q9CQ07; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR PROSITE; PS51450; LRR; 5.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Leucine-rich repeat; Reference proteome;
KW Repeat.
FT CHAIN 1..262
FT /note="Leucine-rich repeat-containing protein 18"
FT /id="PRO_0000084473"
FT REPEAT 28..49
FT /note="LRR 1"
FT REPEAT 51..72
FT /note="LRR 2"
FT REPEAT 74..95
FT /note="LRR 3"
FT REPEAT 97..118
FT /note="LRR 4"
FT REPEAT 122..144
FT /note="LRR 5"
FT REPEAT 145..167
FT /note="LRR 6"
FT REPEAT 168..189
FT /note="LRR 7"
FT VAR_SEQ 256..262
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_015741"
FT CONFLICT 32
FT /note="L -> H (in Ref. 2; BAB24391)"
FT /evidence="ECO:0000305"
FT CONFLICT 87
FT /note="K -> M (in Ref. 3; AAH48444)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 262 AA; 29520 MW; DD4981A2C42CAED6 CRC64;
MAKGGKGPKG KKITLNVAKN CIKITFDGRK RLDLSKMGIT TFPKCILRLS DIDELDLSRN
MIRKIPDSIA KFQNLRWLDL HSNYIDKLPE SIGQMTSLLF LNVSNNRLTT NGLPVELNQL
KNIRTVNLGL NHLDSVPTTL GALKELHEVG LHDNLLTTIP ASIAKLPKLK KLNIKRNPFP
NADESEMFVD SIKRLENLYL VEEKDMCSSC LQRCQQARDK LNKIKSMAPS APRKALFSNL
VSPNSTAKDA QEEWRLRSPS TF
