ID   LRC18_RAT               Reviewed;         256 AA.
AC   Q66HD6;
DT   27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Leucine-rich repeat-containing protein 18;
GN   Name=Lrrc18;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in the regulation of spermatogenesis and
CC       sperm maturation.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
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DR   EMBL; BC081908; AAH81908.1; -; mRNA.
DR   RefSeq; NP_001014021.1; NM_001013999.1.
DR   RefSeq; XP_017455572.1; XM_017600083.1.
DR   AlphaFoldDB; Q66HD6; -.
DR   SMR; Q66HD6; -.
DR   STRING; 10116.ENSRNOP00000027204; -.
DR   PaxDb; Q66HD6; -.
DR   PRIDE; Q66HD6; -.
DR   DNASU; 306278; -.
DR   Ensembl; ENSRNOT00000027204; ENSRNOP00000027204; ENSRNOG00000020080.
DR   GeneID; 306278; -.
DR   KEGG; rno:306278; -.
DR   UCSC; RGD:1311738; rat.
DR   CTD; 474354; -.
DR   RGD; 1311738; Lrrc18.
DR   eggNOG; KOG0619; Eukaryota.
DR   GeneTree; ENSGT00940000156026; -.
DR   HOGENOM; CLU_000288_18_15_1; -.
DR   InParanoid; Q66HD6; -.
DR   OMA; NFPKCIL; -.
DR   OrthoDB; 1059633at2759; -.
DR   PhylomeDB; Q66HD6; -.
DR   TreeFam; TF331129; -.
DR   PRO; PR:Q66HD6; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   Bgee; ENSRNOG00000020080; Expressed in testis and 4 other tissues.
DR   Genevisible; Q66HD6; RN.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13855; LRR_8; 1.
DR   SMART; SM00369; LRR_TYP; 4.
DR   PROSITE; PS51450; LRR; 5.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..256
FT                   /note="Leucine-rich repeat-containing protein 18"
FT                   /id="PRO_0000084474"
FT   REPEAT          28..49
FT                   /note="LRR 1"
FT   REPEAT          51..72
FT                   /note="LRR 2"
FT   REPEAT          74..95
FT                   /note="LRR 3"
FT   REPEAT          97..118
FT                   /note="LRR 4"
FT   REPEAT          122..144
FT                   /note="LRR 5"
FT   REPEAT          145..167
FT                   /note="LRR 6"
FT   REPEAT          168..189
FT                   /note="LRR 7"
FT   REPEAT          194..215
FT                   /note="LRR 8"
SQ   SEQUENCE   256 AA;  28845 MW;  C6A6EDE050DCCDB4 CRC64;
     MAKGGKSPKG KKITLNVAKN CIKITFDGRK RLDLSKMGIT TFPKCILRLN EIDELDLSRN
     MIRKIPDSIS KFQNLRWLDL HSNYIDKLPE SIGQMTSLLF LNVSNNRLTT NGLPVELNQL
     KNIRTVNLGL NHLDSVPTTL GALKELHEVG LHDNLLTSIP AGISKLPKLK KLNVKRNPFP
     KPDESDMFVD SIKRLENLYL VEEKDLCSSC LQKCQQARDK LNKIRSMAPS APRKAIFSNL
     VSPNSTAKES QEEWSV