LRC20_HUMAN
ID LRC20_HUMAN Reviewed; 184 AA.
AC Q8TCA0; Q5T6D4; Q5T6D6; Q9NVA6; Q9NVG3;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Leucine-rich repeat-containing protein 20;
GN Name=LRRC20; ORFNames=UNQ2429/PRO4989;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-175, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q8TCA0; O60784-2: TOM1; NbExp=3; IntAct=EBI-10274039, EBI-12117154;
CC Q8TCA0; O96006: ZBED1; NbExp=6; IntAct=EBI-10274039, EBI-740037;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8TCA0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TCA0-2; Sequence=VSP_015933;
CC Name=3;
CC IsoId=Q8TCA0-3; Sequence=VSP_015934;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA91849.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY358318; AAQ88684.1; -; mRNA.
DR EMBL; AK001613; BAA91789.1; -; mRNA.
DR EMBL; AK001706; BAA91849.1; ALT_SEQ; mRNA.
DR EMBL; AK094734; BAC04409.1; -; mRNA.
DR EMBL; AC022532; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL355138; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC024001; AAH24001.1; -; mRNA.
DR CCDS; CCDS7300.1; -. [Q8TCA0-3]
DR CCDS; CCDS7301.1; -. [Q8TCA0-2]
DR CCDS; CCDS7302.1; -. [Q8TCA0-1]
DR RefSeq; NP_001265140.1; NM_001278211.1. [Q8TCA0-1]
DR RefSeq; NP_001265141.1; NM_001278212.1. [Q8TCA0-1]
DR RefSeq; NP_001265142.1; NM_001278213.1. [Q8TCA0-2]
DR RefSeq; NP_001265143.1; NM_001278214.1.
DR RefSeq; NP_060675.1; NM_018205.3. [Q8TCA0-3]
DR RefSeq; NP_060709.2; NM_018239.3. [Q8TCA0-2]
DR RefSeq; NP_997002.1; NM_207119.2. [Q8TCA0-1]
DR RefSeq; XP_016871863.1; XM_017016374.1. [Q8TCA0-1]
DR RefSeq; XP_016871864.1; XM_017016375.1. [Q8TCA0-1]
DR AlphaFoldDB; Q8TCA0; -.
DR SMR; Q8TCA0; -.
DR BioGRID; 120517; 12.
DR IntAct; Q8TCA0; 4.
DR STRING; 9606.ENSP00000348043; -.
DR iPTMnet; Q8TCA0; -.
DR PhosphoSitePlus; Q8TCA0; -.
DR BioMuta; LRRC20; -.
DR DMDM; 74762612; -.
DR EPD; Q8TCA0; -.
DR jPOST; Q8TCA0; -.
DR MassIVE; Q8TCA0; -.
DR MaxQB; Q8TCA0; -.
DR PaxDb; Q8TCA0; -.
DR PeptideAtlas; Q8TCA0; -.
DR PRIDE; Q8TCA0; -.
DR ProteomicsDB; 74105; -. [Q8TCA0-1]
DR ProteomicsDB; 74106; -. [Q8TCA0-2]
DR ProteomicsDB; 74107; -. [Q8TCA0-3]
DR Antibodypedia; 29015; 72 antibodies from 18 providers.
DR DNASU; 55222; -.
DR Ensembl; ENST00000355790.8; ENSP00000348043.4; ENSG00000172731.15. [Q8TCA0-1]
DR Ensembl; ENST00000357631.6; ENSP00000350255.2; ENSG00000172731.15. [Q8TCA0-3]
DR Ensembl; ENST00000358141.6; ENSP00000350860.2; ENSG00000172731.15. [Q8TCA0-2]
DR Ensembl; ENST00000373224.5; ENSP00000362321.1; ENSG00000172731.15. [Q8TCA0-1]
DR Ensembl; ENST00000395011.5; ENSP00000378458.1; ENSG00000172731.15. [Q8TCA0-2]
DR Ensembl; ENST00000446961.4; ENSP00000413745.2; ENSG00000172731.15. [Q8TCA0-1]
DR GeneID; 55222; -.
DR KEGG; hsa:55222; -.
DR MANE-Select; ENST00000446961.4; ENSP00000413745.2; NM_001278212.2; NP_001265141.1.
DR UCSC; uc001jqx.3; human. [Q8TCA0-1]
DR CTD; 55222; -.
DR DisGeNET; 55222; -.
DR GeneCards; LRRC20; -.
DR HGNC; HGNC:23421; LRRC20.
DR HPA; ENSG00000172731; Group enriched (skeletal muscle, tongue).
DR neXtProt; NX_Q8TCA0; -.
DR OpenTargets; ENSG00000172731; -.
DR PharmGKB; PA134935389; -.
DR VEuPathDB; HostDB:ENSG00000172731; -.
DR eggNOG; KOG4579; Eukaryota.
DR GeneTree; ENSGT00730000111199; -.
DR HOGENOM; CLU_070683_2_1_1; -.
DR InParanoid; Q8TCA0; -.
DR OMA; KCNLRNN; -.
DR PhylomeDB; Q8TCA0; -.
DR TreeFam; TF319816; -.
DR PathwayCommons; Q8TCA0; -.
DR SignaLink; Q8TCA0; -.
DR BioGRID-ORCS; 55222; 10 hits in 1075 CRISPR screens.
DR GenomeRNAi; 55222; -.
DR Pharos; Q8TCA0; Tdark.
DR PRO; PR:Q8TCA0; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q8TCA0; protein.
DR Bgee; ENSG00000172731; Expressed in hindlimb stylopod muscle and 174 other tissues.
DR ExpressionAtlas; Q8TCA0; baseline and differential.
DR Genevisible; Q8TCA0; HS.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR037384; LRRC20.
DR PANTHER; PTHR16083:SF2; PTHR16083:SF2; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Leucine-rich repeat; Phosphoprotein;
KW Reference proteome; Repeat.
FT CHAIN 1..184
FT /note="Leucine-rich repeat-containing protein 20"
FT /id="PRO_0000084475"
FT REPEAT 51..72
FT /note="LRR 1"
FT REPEAT 75..96
FT /note="LRR 2"
FT REPEAT 98..120
FT /note="LRR 3"
FT REPEAT 121..141
FT /note="LRR 4"
FT REPEAT 145..167
FT /note="LRR 5"
FT MOD_RES 175
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 28..77
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_015933"
FT VAR_SEQ 78..133
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_015934"
SQ SEQUENCE 184 AA; 20509 MW; 1E0443D40FE672EC CRC64;
MLKKMGEAVA RVARKVNETV ESGSDTLDLA ECKLVSFPIG IYKVLRNVSG QIHLITLANN
ELKSLTSKFM TTFSQLRELH LEGNFLHRLP SEVSALQHLK AIDLSRNQFQ DFPEQLTALP
ALETINLEEN EIVDVPVEKL AAMPALRSIN LRFNPLNAEV RVIAPPLIKF DMLMSPEGAR
APLP
