LRC20_MOUSE
ID LRC20_MOUSE Reviewed; 184 AA.
AC Q8CI70;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Leucine-rich repeat-containing protein 20;
GN Name=Lrrc20;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, Brain cortex, Liver, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
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DR EMBL; AK139384; BAE23986.1; -; mRNA.
DR EMBL; AK145920; BAE26751.1; -; mRNA.
DR EMBL; AK150142; BAE29337.1; -; mRNA.
DR EMBL; AK150246; BAE29410.1; -; mRNA.
DR EMBL; AK136380; BAE22954.1; -; mRNA.
DR EMBL; BC036304; AAH36304.1; -; mRNA.
DR CCDS; CCDS23881.1; -.
DR RefSeq; NP_705770.1; NM_153542.1.
DR AlphaFoldDB; Q8CI70; -.
DR SMR; Q8CI70; -.
DR STRING; 10090.ENSMUSP00000048042; -.
DR PhosphoSitePlus; Q8CI70; -.
DR EPD; Q8CI70; -.
DR MaxQB; Q8CI70; -.
DR PaxDb; Q8CI70; -.
DR PeptideAtlas; Q8CI70; -.
DR PRIDE; Q8CI70; -.
DR ProteomicsDB; 287262; -.
DR Antibodypedia; 29015; 72 antibodies from 18 providers.
DR Ensembl; ENSMUST00000049242; ENSMUSP00000048042; ENSMUSG00000037151.
DR GeneID; 216011; -.
DR KEGG; mmu:216011; -.
DR UCSC; uc007fgc.1; mouse.
DR CTD; 55222; -.
DR MGI; MGI:2387182; Lrrc20.
DR VEuPathDB; HostDB:ENSMUSG00000037151; -.
DR eggNOG; KOG4579; Eukaryota.
DR GeneTree; ENSGT00730000111199; -.
DR HOGENOM; CLU_070683_2_1_1; -.
DR InParanoid; Q8CI70; -.
DR OMA; KCNLRNN; -.
DR OrthoDB; 1291630at2759; -.
DR PhylomeDB; Q8CI70; -.
DR TreeFam; TF319816; -.
DR BioGRID-ORCS; 216011; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Lrrc20; mouse.
DR PRO; PR:Q8CI70; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8CI70; protein.
DR Bgee; ENSMUSG00000037151; Expressed in hindlimb stylopod muscle and 231 other tissues.
DR Genevisible; Q8CI70; MM.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR037384; LRRC20.
DR PANTHER; PTHR16083:SF2; PTHR16083:SF2; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 1.
PE 1: Evidence at protein level;
KW Leucine-rich repeat; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..184
FT /note="Leucine-rich repeat-containing protein 20"
FT /id="PRO_0000084476"
FT REPEAT 23..44
FT /note="LRR 1"
FT REPEAT 51..72
FT /note="LRR 2"
FT REPEAT 75..96
FT /note="LRR 3"
FT REPEAT 98..120
FT /note="LRR 4"
FT REPEAT 121..141
FT /note="LRR 5"
FT REPEAT 145..167
FT /note="LRR 6"
FT MOD_RES 175
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8TCA0"
SQ SEQUENCE 184 AA; 20809 MW; 6398385548FC84E7 CRC64;
MLRKMGEAVA RVARKVNETV ESGSDTLDLA DCKLVSFPIC IYKVLRNVSD QIHLITLANN
ELKSLTSKFM TTFNQLRELR LEGNYLFRLP NEVSSLQHLR AIDLSRNQFQ DFPEQLTTLP
ALETINLEEN EIVDVPVEKL AAMPALRVIN LRLNPLSADV RVIAPPLIKF DMLMSPEDTR
APPP
