LRC23_HUMAN
ID LRC23_HUMAN Reviewed; 343 AA.
AC Q53EV4; A8K8C6; D3DUT1; Q8N6K6; Q92977; Q99620;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Leucine-rich repeat-containing protein 23;
DE AltName: Full=Leucine-rich protein B7;
GN Name=LRRC23; Synonyms=LRPB7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2).
RX PubMed=9074930; DOI=10.1101/gr.7.3.268;
RA Ansari-Lari M.A., Shen Y., Muzny D.M., Lee W., Gibbs R.A.;
RT "Large-scale sequencing in human chromosome 12p13: experimental and
RT computational gene structure determination.";
RL Genome Res. 7:268-280(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT LEU-124.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q53EV4; Q53EZ4: CEP55; NbExp=3; IntAct=EBI-13435308, EBI-747776;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q53EV4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q53EV4-2; Sequence=VSP_021889;
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DR EMBL; U47924; AAB51319.1; -; Genomic_DNA.
DR EMBL; U72508; AAC51638.1; -; mRNA.
DR EMBL; AK223535; BAD97255.1; -; mRNA.
DR EMBL; AK292291; BAF84980.1; -; mRNA.
DR EMBL; CH471116; EAW88716.1; -; Genomic_DNA.
DR EMBL; CH471116; EAW88714.1; -; Genomic_DNA.
DR EMBL; CH471116; EAW88715.1; -; Genomic_DNA.
DR EMBL; BC029858; AAH29858.1; -; mRNA.
DR CCDS; CCDS8568.1; -. [Q53EV4-2]
DR CCDS; CCDS8569.1; -. [Q53EV4-1]
DR RefSeq; NP_001128689.1; NM_001135217.1. [Q53EV4-1]
DR RefSeq; NP_008923.1; NM_006992.3. [Q53EV4-2]
DR RefSeq; NP_964013.1; NM_201650.2. [Q53EV4-1]
DR AlphaFoldDB; Q53EV4; -.
DR SMR; Q53EV4; -.
DR BioGRID; 115527; 28.
DR IntAct; Q53EV4; 2.
DR STRING; 9606.ENSP00000390932; -.
DR iPTMnet; Q53EV4; -.
DR PhosphoSitePlus; Q53EV4; -.
DR BioMuta; LRRC23; -.
DR DMDM; 119371993; -.
DR MassIVE; Q53EV4; -.
DR PaxDb; Q53EV4; -.
DR PeptideAtlas; Q53EV4; -.
DR PRIDE; Q53EV4; -.
DR ProteomicsDB; 62450; -. [Q53EV4-1]
DR ProteomicsDB; 62451; -. [Q53EV4-2]
DR Antibodypedia; 35084; 99 antibodies from 18 providers.
DR DNASU; 10233; -.
DR Ensembl; ENST00000007969.12; ENSP00000007969.8; ENSG00000010626.15. [Q53EV4-1]
DR Ensembl; ENST00000323702.9; ENSP00000317464.5; ENSG00000010626.15. [Q53EV4-2]
DR Ensembl; ENST00000443597.7; ENSP00000390932.2; ENSG00000010626.15. [Q53EV4-1]
DR GeneID; 10233; -.
DR KEGG; hsa:10233; -.
DR MANE-Select; ENST00000443597.7; ENSP00000390932.2; NM_001135217.2; NP_001128689.1.
DR UCSC; uc001qrp.4; human. [Q53EV4-1]
DR CTD; 10233; -.
DR DisGeNET; 10233; -.
DR GeneCards; LRRC23; -.
DR HGNC; HGNC:19138; LRRC23.
DR HPA; ENSG00000010626; Tissue enhanced (fallopian).
DR neXtProt; NX_Q53EV4; -.
DR OpenTargets; ENSG00000010626; -.
DR PharmGKB; PA143485529; -.
DR VEuPathDB; HostDB:ENSG00000010626; -.
DR eggNOG; KOG0531; Eukaryota.
DR GeneTree; ENSGT00940000159748; -.
DR HOGENOM; CLU_056804_1_1_1; -.
DR InParanoid; Q53EV4; -.
DR OMA; LENPCTD; -.
DR PhylomeDB; Q53EV4; -.
DR TreeFam; TF329158; -.
DR PathwayCommons; Q53EV4; -.
DR SignaLink; Q53EV4; -.
DR BioGRID-ORCS; 10233; 9 hits in 1075 CRISPR screens.
DR ChiTaRS; LRRC23; human.
DR GeneWiki; LRRC23; -.
DR GenomeRNAi; 10233; -.
DR Pharos; Q53EV4; Tdark.
DR PRO; PR:Q53EV4; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q53EV4; protein.
DR Bgee; ENSG00000010626; Expressed in right uterine tube and 144 other tissues.
DR ExpressionAtlas; Q53EV4; baseline and differential.
DR Genevisible; Q53EV4; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13516; LRR_6; 1.
DR PROSITE; PS51450; LRR; 7.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Leucine-rich repeat; Reference proteome;
KW Repeat.
FT CHAIN 1..343
FT /note="Leucine-rich repeat-containing protein 23"
FT /id="PRO_0000264236"
FT REPEAT 92..113
FT /note="LRR 1"
FT REPEAT 114..134
FT /note="LRR 2"
FT REPEAT 135..155
FT /note="LRR 3"
FT REPEAT 156..177
FT /note="LRR 4"
FT REPEAT 180..200
FT /note="LRR 5"
FT REPEAT 201..222
FT /note="LRR 6"
FT REPEAT 223..244
FT /note="LRR 7"
FT REPEAT 246..267
FT /note="LRR 8"
FT DOMAIN 280..318
FT /note="LRRCT"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 307..329
FT /evidence="ECO:0000255"
FT COMPBIAS 1..28
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..336
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 254..343
FT /note="GNMVANLGELAKLRDLPKLRALVLLDNPCTDETSYRQEALVQMPYLERLDKE
FT FYEEEERAEADVIRQRLKEEKEQEPEPQRDLEPEQSLI -> RSKTLAFRPDQTPRGSH
FT HMYDREQRMPVFAPKLEIHHNLRPRICSVPVLWAVWGAEWGA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9074930"
FT /id="VSP_021889"
FT VARIANT 65
FT /note="N -> H (in dbSNP:rs2071072)"
FT /id="VAR_051106"
FT VARIANT 124
FT /note="R -> L (in dbSNP:rs2071073)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_051107"
FT VARIANT 317
FT /note="V -> E (in dbSNP:rs1057077)"
FT /id="VAR_051108"
FT CONFLICT 153
FT /note="S -> P (in Ref. 3; BAD97255)"
FT /evidence="ECO:0000305"
FT CONFLICT Q53EV4-2:276
FT /note="E -> G (in Ref. 1; AAC51638)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 343 AA; 39761 MW; 27FF858EC42AFE21 CRC64;
MSDEDDLEDS EPDQDDSEKE EDEKETEEGE DYRKEGEEFP EEWLPTPLTE DMMKEGLSLL
CKTGNGLAHA YVKLEVKERD LTDIYLLRSY IHLRYVDISE NHLTDLSPLN YLTHLLWLKA
DGNRLRSAQM NELPYLQIAS FAYNQITDTE GISHPRLETL NLKGNSIHMV TGLDPEKLIS
LHTVELRGNQ LESTLGINLP KLKNLYLAQN MLKKVEGLED LSNLTTLHLR DNQIDTLSGF
SREMKSLQYL NLRGNMVANL GELAKLRDLP KLRALVLLDN PCTDETSYRQ EALVQMPYLE
RLDKEFYEEE ERAEADVIRQ RLKEEKEQEP EPQRDLEPEQ SLI
