ID   LRC23_MOUSE             Reviewed;         340 AA.
AC   O35125;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=Leucine-rich repeat-containing protein 23;
DE   AltName: Full=Leucine-rich protein B7;
GN   Name=Lrrc23; Synonyms=Lrpb7;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9445485;
RA   Ansari-Lari M.A., Oeltjen J.C., Schwartz S., Zhang Z., Muzny D.M., Lu J.,
RA   Gorrell J.H., Chinault A.C., Belmont J.W., Miller W., Gibbs R.A.;
RT   "Comparative sequence analysis of a gene-rich cluster at human chromosome
RT   12p13 and its syntenic region in mouse chromosome 6.";
RL   Genome Res. 8:29-40(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
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DR   EMBL; AC002397; AAC36001.1; -; Genomic_DNA.
DR   EMBL; BC049601; AAH49601.1; -; mRNA.
DR   CCDS; CCDS20528.1; -.
DR   RefSeq; NP_001289484.1; NM_001302555.1.
DR   RefSeq; XP_006505722.1; XM_006505659.3.
DR   RefSeq; XP_006505723.1; XM_006505660.3.
DR   RefSeq; XP_006505726.1; XM_006505663.3.
DR   RefSeq; XP_011239541.1; XM_011241239.2.
DR   RefSeq; XP_011239542.1; XM_011241240.2.
DR   AlphaFoldDB; O35125; -.
DR   SMR; O35125; -.
DR   STRING; 10090.ENSMUSP00000032218; -.
DR   PhosphoSitePlus; O35125; -.
DR   MaxQB; O35125; -.
DR   PaxDb; O35125; -.
DR   PRIDE; O35125; -.
DR   ProteomicsDB; 252668; -.
DR   Antibodypedia; 35084; 99 antibodies from 18 providers.
DR   Ensembl; ENSMUST00000032218; ENSMUSP00000032218; ENSMUSG00000030125.
DR   Ensembl; ENSMUST00000112475; ENSMUSP00000108094; ENSMUSG00000030125.
DR   GeneID; 16977; -.
DR   KEGG; mmu:16977; -.
DR   UCSC; uc009drv.2; mouse.
DR   CTD; 10233; -.
DR   MGI; MGI:1315192; Lrrc23.
DR   VEuPathDB; HostDB:ENSMUSG00000030125; -.
DR   eggNOG; KOG0531; Eukaryota.
DR   GeneTree; ENSGT00940000159748; -.
DR   HOGENOM; CLU_056804_1_1_1; -.
DR   InParanoid; O35125; -.
DR   OMA; LENPCTD; -.
DR   OrthoDB; 1105813at2759; -.
DR   PhylomeDB; O35125; -.
DR   TreeFam; TF329158; -.
DR   BioGRID-ORCS; 16977; 1 hit in 74 CRISPR screens.
DR   PRO; PR:O35125; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; O35125; protein.
DR   Bgee; ENSMUSG00000030125; Expressed in spermatocyte and 74 other tissues.
DR   ExpressionAtlas; O35125; baseline and differential.
DR   Genevisible; O35125; MM.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IDA:MGI.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13516; LRR_6; 1.
DR   SMART; SM00369; LRR_TYP; 3.
DR   PROSITE; PS51450; LRR; 6.
PE   1: Evidence at protein level;
KW   Coiled coil; Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..340
FT                   /note="Leucine-rich repeat-containing protein 23"
FT                   /id="PRO_0000264237"
FT   REPEAT          89..110
FT                   /note="LRR 1"
FT   REPEAT          111..134
FT                   /note="LRR 2"
FT   REPEAT          177..197
FT                   /note="LRR 3"
FT   REPEAT          198..219
FT                   /note="LRR 4"
FT   REPEAT          220..241
FT                   /note="LRR 5"
FT   REPEAT          243..264
FT                   /note="LRR 6"
FT   DOMAIN          277..315
FT                   /note="LRRCT"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          317..340
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          305..328
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..23
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..38
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   340 AA;  39292 MW;  AD81FFB8D96AA650 CRC64;
     MSDEDDVDDV DAEQDEVESD KEIEEWEDYR KETEEASEEW LPTPITEAMM KEGLSLLCKI
     GSGLAHAYIK LEAKDRDLTD ISLLRSYIHL RYVDISENHI TDISPLNSLT HLLWLKADGN
     QLRSARMNEL PYLQIASFSY NQIIDTEGIF HPRLGSLDLK GNRIHQVTGL DPERLSSLHT
     LELRGNQLES TKGIYLPKLK NLYLAQNLLK KVEGLENLSN LTTLHLRDNQ IETLNGFSQE
     MKSLQYLNLR SNMISDLAEL AKLRDLPKLR ALVLLDNPCA DETDYRQEAL VQMAHLERLD
     KEFYEDDDRA EAEEIRQRLK EEQDQDLDPD QDMEPYLPPV