LRC24_HUMAN
ID LRC24_HUMAN Reviewed; 513 AA.
AC Q50LG9;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Leucine-rich repeat-containing protein 24;
DE Flags: Precursor;
GN Name=LRRC24;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RA Shimizu N., Asakawa S., Shimizu A., Yamazaki S., Ishikawa S.K.;
RT "Novel gene containing leucine rich repeat on human chromosome 8.";
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AB178281; BAD97811.1; -; mRNA.
DR EMBL; AC084125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC111067; AAI11068.1; -; mRNA.
DR CCDS; CCDS34969.1; -.
DR RefSeq; NP_001019849.2; NM_001024678.3.
DR AlphaFoldDB; Q50LG9; -.
DR SMR; Q50LG9; -.
DR BioGRID; 137417; 14.
DR IntAct; Q50LG9; 2.
DR STRING; 9606.ENSP00000434849; -.
DR GlyGen; Q50LG9; 2 sites.
DR iPTMnet; Q50LG9; -.
DR PhosphoSitePlus; Q50LG9; -.
DR BioMuta; LRRC24; -.
DR DMDM; 296434571; -.
DR MassIVE; Q50LG9; -.
DR PaxDb; Q50LG9; -.
DR PeptideAtlas; Q50LG9; -.
DR PRIDE; Q50LG9; -.
DR ProteomicsDB; 62419; -.
DR Antibodypedia; 49490; 53 antibodies from 14 providers.
DR DNASU; 441381; -.
DR Ensembl; ENST00000529415.7; ENSP00000434849.1; ENSG00000254402.7.
DR GeneID; 441381; -.
DR KEGG; hsa:441381; -.
DR MANE-Select; ENST00000529415.7; ENSP00000434849.1; NM_001024678.4; NP_001019849.2.
DR UCSC; uc003zdm.4; human.
DR CTD; 441381; -.
DR GeneCards; LRRC24; -.
DR HGNC; HGNC:28947; LRRC24.
DR HPA; ENSG00000254402; Tissue enhanced (pituitary).
DR neXtProt; NX_Q50LG9; -.
DR PharmGKB; PA142671520; -.
DR VEuPathDB; HostDB:ENSG00000254402; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000160141; -.
DR HOGENOM; CLU_000288_18_24_1; -.
DR InParanoid; Q50LG9; -.
DR OMA; TWRKVSQ; -.
DR OrthoDB; 393248at2759; -.
DR PhylomeDB; Q50LG9; -.
DR TreeFam; TF320455; -.
DR PathwayCommons; Q50LG9; -.
DR SignaLink; Q50LG9; -.
DR BioGRID-ORCS; 441381; 13 hits in 1016 CRISPR screens.
DR ChiTaRS; LRRC24; human.
DR GenomeRNAi; 441381; -.
DR Pharos; Q50LG9; Tdark.
DR PRO; PR:Q50LG9; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q50LG9; protein.
DR Bgee; ENSG00000254402; Expressed in cortical plate and 91 other tissues.
DR ExpressionAtlas; Q50LG9; baseline and differential.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IEA:Ensembl.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 6.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 6.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Leucine-rich repeat;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..513
FT /note="Leucine-rich repeat-containing protein 24"
FT /id="PRO_0000231596"
FT TRANSMEM 406..426
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 21..50
FT /note="LRRNT"
FT REPEAT 51..72
FT /note="LRR 1"
FT REPEAT 75..96
FT /note="LRR 2"
FT REPEAT 99..120
FT /note="LRR 3"
FT REPEAT 123..144
FT /note="LRR 4"
FT REPEAT 147..168
FT /note="LRR 5"
FT REPEAT 171..192
FT /note="LRR 6"
FT DOMAIN 204..259
FT /note="LRRCT"
FT DOMAIN 260..361
FT /note="Ig-like C2-type"
FT REGION 365..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..384
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 334
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 363
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 281..345
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CONFLICT 494
FT /note="E -> A (in Ref. 1; BAD97811 and 3; AAI11068)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 513 AA; 55257 MW; 3770FA87B4B9C1DE CRC64;
MALRAPALLP LLLLLLPLRA AGCPAACRCY SATVECGALR LRVVPLGIPP GTQTLFLQDN
NIARLEPGAL APLAALRRLY LHNNSLRALE AGAFRAQPRL LELALTSNRL RGLRSGAFVG
LAQLRVLYLA GNQLARLLDF TFLHLPRLQE LHLQENSIEL LEDQALAGLS SLALLDLSRN
QLGTISREAL QPLASLQVLR LTENPWRCDC ALHWLGAWIK EGGQRLLTSR DRKIMCAEPP
RLALQSLLDV SHSSLICIPP SVHVQPLELT ANLGEDLRVA CQASGYPQPL VTWRKVPQPR
EGRPRAQAQL EGGLLGLGGH SASDTGSGML FLSNITLAHA GKYECEASNA GGAARVPFRL
LVNASRQQPQ QPAQPPPPAA RPAGSEPRPE AGSMAFRALG VATQTAIAAA IALLALTALL
LVAMICRRRR RRKKARGPPG EGALFVNDYL DGPCTFAQLE ELRDERGHEM FVINRSKPLF
AEGPAEAPAD CGPEQGAGPG LRVPPPVAYE IHC
