LRC24_MOUSE
ID LRC24_MOUSE Reviewed; 521 AA.
AC Q8BHA1; Q14AD4;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Leucine-rich repeat-containing protein 24;
DE Flags: Precursor;
GN Name=Lrrc24;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Olfactory bulb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK048678; BAC33419.1; -; mRNA.
DR EMBL; AK078176; BAC37163.1; -; mRNA.
DR EMBL; BC116884; AAI16885.1; -; mRNA.
DR EMBL; BC116886; AAI16887.1; -; mRNA.
DR CCDS; CCDS27590.1; -.
DR RefSeq; NP_932787.1; NM_198119.2.
DR AlphaFoldDB; Q8BHA1; -.
DR SMR; Q8BHA1; -.
DR BioGRID; 237562; 1.
DR IntAct; Q8BHA1; 1.
DR STRING; 10090.ENSMUSP00000061906; -.
DR GlyConnect; 2468; 1 N-Linked glycan (1 site).
DR GlyGen; Q8BHA1; 3 sites, 1 N-linked glycan (1 site).
DR PhosphoSitePlus; Q8BHA1; -.
DR MaxQB; Q8BHA1; -.
DR PaxDb; Q8BHA1; -.
DR PRIDE; Q8BHA1; -.
DR ProteomicsDB; 287263; -.
DR Antibodypedia; 49490; 53 antibodies from 14 providers.
DR DNASU; 378937; -.
DR Ensembl; ENSMUST00000049956; ENSMUSP00000061906; ENSMUSG00000033707.
DR GeneID; 378937; -.
DR KEGG; mmu:378937; -.
DR UCSC; uc007wme.1; mouse.
DR CTD; 441381; -.
DR MGI; MGI:3605040; Lrrc24.
DR VEuPathDB; HostDB:ENSMUSG00000033707; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000160141; -.
DR HOGENOM; CLU_000288_18_24_1; -.
DR InParanoid; Q8BHA1; -.
DR OMA; TWRKVSQ; -.
DR OrthoDB; 393248at2759; -.
DR PhylomeDB; Q8BHA1; -.
DR TreeFam; TF320455; -.
DR BioGRID-ORCS; 378937; 4 hits in 72 CRISPR screens.
DR PRO; PR:Q8BHA1; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q8BHA1; protein.
DR Bgee; ENSMUSG00000033707; Expressed in superior frontal gyrus and 87 other tissues.
DR Genevisible; Q8BHA1; MM.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IDA:MGI.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 6.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 6.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Leucine-rich repeat;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..521
FT /note="Leucine-rich repeat-containing protein 24"
FT /id="PRO_0000231597"
FT TRANSMEM 414..434
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 24..58
FT /note="LRRNT"
FT REPEAT 59..80
FT /note="LRR 1"
FT REPEAT 83..104
FT /note="LRR 2"
FT REPEAT 107..128
FT /note="LRR 3"
FT REPEAT 131..152
FT /note="LRR 4"
FT REPEAT 155..176
FT /note="LRR 5"
FT REPEAT 179..200
FT /note="LRR 6"
FT DOMAIN 212..267
FT /note="LRRCT"
FT DOMAIN 268..371
FT /note="Ig-like C2-type"
FT REGION 306..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 91
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 342
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 371
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 289..353
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 521 AA; 56334 MW; 3D1E4BEE302284A6 CRC64;
MALRAPTLLL LLLGLLLLPL LPGLPPRATG CPAACRCYSA TVECGALRLR VVPPGIPPGT
QTLFLQDNSI AHLEQGSLAP LAALRHLYLH NNTLRALESG AFRAQPRLLE LALTGNRLRG
LRGGAFVGLV QLRVLYLAGN QLAKLLDFTF LHLPRLQELH LQENSIELLE DQALAGLSSL
ALLDLSRNQL GTISKEALQP LSSLQVLRLT ENPWRCDCAL HWLGSWIKEG GRRLLSSRDK
KITCAEPPRL ALQSLLEVSG GSLICIPPSV NVEPPEFTAN LGEDLQVACQ ASGYPQPLVV
WRKVPQPRDG KPQAQAQLEG GAPGLGGHGT RDTGSGMLFL TNITLAHAGK YECEAANAGG
KARVPFHLLV NASRQQSQQL PDPQAPATRP VGHEPQHEAG SMAFRALGLA TQTAITAAIA
LLALTALLLA AMICRRRRRR KKVPAPSGEG TLFVNDYSDG PCTFAQLEEL RDDHGHEMFV
IDRSKPLFPE VLPEEAPEHN PPDGLKSGLR LPTRVAYEIH C
