LRC26_MOUSE
ID LRC26_MOUSE Reviewed; 331 AA.
AC Q91W20; Q3UUY1;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Leucine-rich repeat-containing protein 26;
DE AltName: Full=BK channel auxiliary gamma subunit LRRC26;
DE Flags: Precursor;
GN Name=Lrrc26;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland, and Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=129, and FVB/N; TISSUE=Colon, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Auxiliary protein of the large-conductance, voltage and
CC calcium-activated potassium channel (BK alpha). Required for the
CC conversion of BK alpha channels from a high-voltage to a low-voltage
CC activated channel type in non-excitable cells. These are characterized
CC by negative membrane voltages and constant low levels of calcium (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with KCNMA1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
CC Note=Localizes to the cytoplasm when expressed at high levels.
CC {ECO:0000250}.
CC -!- DOMAIN: The transmembrane domain is necessary for interaction with
CC KCNMA1. {ECO:0000250}.
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DR EMBL; AK137758; BAE23492.1; -; mRNA.
DR EMBL; AK142669; BAE25154.1; -; mRNA.
DR EMBL; AL732309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC024531; AAH24531.1; -; mRNA.
DR EMBL; BC024539; AAH24539.1; -; mRNA.
DR EMBL; BC004853; AAH04853.1; -; mRNA.
DR CCDS; CCDS15763.1; -.
DR RefSeq; NP_666229.1; NM_146117.2.
DR AlphaFoldDB; Q91W20; -.
DR SMR; Q91W20; -.
DR STRING; 10090.ENSMUSP00000028337; -.
DR iPTMnet; Q91W20; -.
DR PhosphoSitePlus; Q91W20; -.
DR PaxDb; Q91W20; -.
DR PRIDE; Q91W20; -.
DR ProteomicsDB; 287265; -.
DR Antibodypedia; 18941; 97 antibodies from 22 providers.
DR DNASU; 227618; -.
DR Ensembl; ENSMUST00000028337; ENSMUSP00000028337; ENSMUSG00000026961.
DR GeneID; 227618; -.
DR KEGG; mmu:227618; -.
DR UCSC; uc008irg.2; mouse.
DR CTD; 389816; -.
DR MGI; MGI:2385129; Lrrc26.
DR VEuPathDB; HostDB:ENSMUSG00000026961; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000162780; -.
DR HOGENOM; CLU_000288_18_10_1; -.
DR InParanoid; Q91W20; -.
DR OMA; AAFSHCA; -.
DR OrthoDB; 826997at2759; -.
DR PhylomeDB; Q91W20; -.
DR TreeFam; TF334689; -.
DR BioGRID-ORCS; 227618; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q91W20; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q91W20; protein.
DR Bgee; ENSMUSG00000026961; Expressed in ileum and 35 other tissues.
DR Genevisible; Q91W20; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005887; C:integral component of plasma membrane; ISO:MGI.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; ISS:UniProtKB.
DR GO; GO:0099104; F:potassium channel activator activity; ISO:MGI.
DR GO; GO:0015459; F:potassium channel regulator activity; ISS:UniProtKB.
DR GO; GO:0044325; F:transmembrane transporter binding; ISO:MGI.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; ISO:MGI.
DR GO; GO:1903818; P:positive regulation of voltage-gated potassium channel activity; ISO:MGI.
DR GO; GO:0071805; P:potassium ion transmembrane transport; ISO:MGI.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00369; LRR_TYP; 5.
DR SMART; SM00082; LRRCT; 1.
DR PROSITE; PS51450; LRR; 6.
PE 2: Evidence at transcript level;
KW Cell membrane; Cytoplasm; Cytoskeleton; Disulfide bond; Ion channel;
KW Ion transport; Leucine-rich repeat; Membrane; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..26
FT /evidence="ECO:0000250"
FT CHAIN 27..331
FT /note="Leucine-rich repeat-containing protein 26"
FT /id="PRO_0000309361"
FT TOPO_DOM 27..261
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..331
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 34..71
FT /note="LRRNT"
FT REPEAT 72..93
FT /note="LRR 1"
FT REPEAT 96..117
FT /note="LRR 2"
FT REPEAT 120..141
FT /note="LRR 3"
FT REPEAT 144..165
FT /note="LRR 4"
FT REPEAT 168..191
FT /note="LRR 5"
FT DOMAIN 201..255
FT /note="LRRCT"
FT REGION 310..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 43..49
FT /evidence="ECO:0000255"
FT DISULFID 47..57
FT /evidence="ECO:0000255"
FT DISULFID 205..231
FT /evidence="ECO:0000255"
FT DISULFID 207..253
FT /evidence="ECO:0000255"
FT CONFLICT 330
FT /note="Q -> R (in Ref. 1; BAE23492)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 331 AA; 35696 MW; 81659EA77EDC3430 CRC64;
MRGSFFSRLP PQLSLLLLLS LRRVWTQEDI GTAPSKSPVA PECPEACSCS LGGKANCSAL
ALPAVPADLS WQVRSLLLDH NRVSALPPGA FANAGALLYL DLRENRLRSV HARAFWGLGV
LQWLDLSSNQ LETLPPGTFA PLRALSFLSL AGNRLALLEP SILGPLPLLR VLSLQDNSLS
AIEAGLLNNL PALDVLRLHG NPWTCNCALR PLCTWLRKHP RPASETETLL CVSPRLQTLS
LLTAFPDAAF KQCTQSLAAR DLAVVYALGP VSFLASLAIC LALGSVLTAC GARRRRRRRT
TVRHLLRRQL DPEGPPSLED AGSPVTAAIQ A
