ID   LRC26_RAT               Reviewed;         334 AA.
AC   Q6P7C4;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Leucine-rich repeat-containing protein 26;
DE   AltName: Full=BK channel auxiliary gamma subunit LRRC26;
DE   Flags: Precursor;
GN   Name=Lrrc26;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Auxiliary protein of the large-conductance, voltage and
CC       calcium-activated potassium channel (BK alpha). Required for the
CC       conversion of BK alpha channels from a high-voltage to a low-voltage
CC       activated channel type in non-excitable cells. These are characterized
CC       by negative membrane voltages and constant low levels of calcium (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with KCNMA1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
CC       Note=Localizes to the cytoplasm when expressed at high levels.
CC       {ECO:0000250}.
CC   -!- DOMAIN: The transmembrane domain is necessary for interaction with
CC       KCNMA1. {ECO:0000250}.
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DR   EMBL; BC061729; AAH61729.1; -; mRNA.
DR   RefSeq; NP_001014075.1; NM_001014053.1.
DR   AlphaFoldDB; Q6P7C4; -.
DR   SMR; Q6P7C4; -.
DR   STRING; 10116.ENSRNOP00000015242; -.
DR   PaxDb; Q6P7C4; -.
DR   Ensembl; ENSRNOT00000015242; ENSRNOP00000015242; ENSRNOG00000011457.
DR   GeneID; 311803; -.
DR   KEGG; rno:311803; -.
DR   UCSC; RGD:1308398; rat.
DR   CTD; 389816; -.
DR   RGD; 1308398; Lrrc26.
DR   eggNOG; KOG0619; Eukaryota.
DR   GeneTree; ENSGT00940000162780; -.
DR   HOGENOM; CLU_000288_18_10_1; -.
DR   InParanoid; Q6P7C4; -.
DR   OMA; AAFSHCA; -.
DR   OrthoDB; 826997at2759; -.
DR   PhylomeDB; Q6P7C4; -.
DR   TreeFam; TF334689; -.
DR   PRO; PR:Q6P7C4; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000011457; Expressed in stomach and 5 other tissues.
DR   Genevisible; Q6P7C4; RN.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISO:RGD.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; ISS:UniProtKB.
DR   GO; GO:0099104; F:potassium channel activator activity; ISO:RGD.
DR   GO; GO:0015459; F:potassium channel regulator activity; ISS:UniProtKB.
DR   GO; GO:0044325; F:transmembrane transporter binding; ISO:RGD.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; ISO:RGD.
DR   GO; GO:1903818; P:positive regulation of voltage-gated potassium channel activity; ISO:RGD.
DR   GO; GO:0071805; P:potassium ion transmembrane transport; ISO:RGD.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13855; LRR_8; 2.
DR   SMART; SM00369; LRR_TYP; 5.
DR   SMART; SM00082; LRRCT; 1.
DR   PROSITE; PS51450; LRR; 5.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Cytoskeleton; Disulfide bond; Ion channel;
KW   Ion transport; Leucine-rich repeat; Membrane; Reference proteome; Repeat;
KW   Signal; Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000250"
FT   CHAIN           31..334
FT                   /note="Leucine-rich repeat-containing protein 26"
FT                   /id="PRO_0000309362"
FT   TOPO_DOM        31..265
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        266..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        287..334
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          38..75
FT                   /note="LRRNT"
FT   REPEAT          76..97
FT                   /note="LRR 1"
FT   REPEAT          100..121
FT                   /note="LRR 2"
FT   REPEAT          124..145
FT                   /note="LRR 3"
FT   REPEAT          148..169
FT                   /note="LRR 4"
FT   REPEAT          172..194
FT                   /note="LRR 5"
FT   DOMAIN          205..259
FT                   /note="LRRCT"
FT   REGION          312..334
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        47..53
FT                   /evidence="ECO:0000255"
FT   DISULFID        51..61
FT                   /evidence="ECO:0000255"
FT   DISULFID        209..235
FT                   /evidence="ECO:0000255"
FT   DISULFID        211..257
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   334 AA;  36073 MW;  3578807472CFEA5D CRC64;
     MRGSFFSRLP PQLSLLLLLL LLLSWRRVWT QEHIGTDPSK SPVAPVCPEA CSCSPGGKAN
     CSALALPAVP AGLSWQVRSL LLDRNRVSTL PPGAFADAGA LLYLVLRENR LRSVHARAFW
     GLGVLQRLDL SSNQLETLSP GTFTPLRALS FLSLAGNRLA LLEPSILGPL PLLRVLSLQD
     NSLSALEAGL LNSLPALDVL RLHGNPWACS CALRPLCTWL RKHPRPTSET ETLLCVSPKL
     QTLNLLTDFP DNAFKQCTQS LAARDLAVVY ALGPASFLAS LAICLALGSV LTACGARRRR
     RRTTVRHLIR RQPDPEGPAS LEDVGSPTTT AIQA