LRC27_MOUSE
ID LRC27_MOUSE Reviewed; 523 AA.
AC Q80YS5; Q9D6Z2;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Leucine-rich repeat-containing protein 27;
GN Name=Lrrc27;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 395-523.
RC STRAIN=C3H/HeJ, and C57BL/6J; TISSUE=Brain, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB26510.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAE38281.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BC050816; AAH50816.1; -; mRNA.
DR EMBL; AK009798; BAB26510.1; ALT_INIT; mRNA.
DR EMBL; AK165593; BAE38281.1; ALT_INIT; mRNA.
DR CCDS; CCDS21953.1; -.
DR RefSeq; NP_081440.1; NM_027164.1.
DR RefSeq; XP_006536325.1; XM_006536262.3.
DR RefSeq; XP_006536327.1; XM_006536264.1.
DR RefSeq; XP_006536328.1; XM_006536265.3.
DR RefSeq; XP_011248164.1; XM_011249862.2.
DR RefSeq; XP_011248165.1; XM_011249863.2.
DR RefSeq; XP_011248166.1; XM_011249864.1.
DR RefSeq; XP_011248167.1; XM_011249865.1.
DR AlphaFoldDB; Q80YS5; -.
DR SMR; Q80YS5; -.
DR STRING; 10090.ENSMUSP00000016124; -.
DR PhosphoSitePlus; Q80YS5; -.
DR PaxDb; Q80YS5; -.
DR PRIDE; Q80YS5; -.
DR ProteomicsDB; 292025; -.
DR Antibodypedia; 48541; 11 antibodies from 8 providers.
DR DNASU; 76612; -.
DR Ensembl; ENSMUST00000016124; ENSMUSP00000016124; ENSMUSG00000015980.
DR GeneID; 76612; -.
DR KEGG; mmu:76612; -.
DR UCSC; uc009kfm.1; mouse.
DR CTD; 80313; -.
DR MGI; MGI:1923862; Lrrc27.
DR VEuPathDB; HostDB:ENSMUSG00000015980; -.
DR eggNOG; KOG0620; Eukaryota.
DR GeneTree; ENSGT00390000007203; -.
DR HOGENOM; CLU_045069_0_0_1; -.
DR InParanoid; Q80YS5; -.
DR OMA; PQNIFFN; -.
DR OrthoDB; 1019074at2759; -.
DR PhylomeDB; Q80YS5; -.
DR TreeFam; TF351877; -.
DR BioGRID-ORCS; 76612; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Lrrc27; mouse.
DR PRO; PR:Q80YS5; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q80YS5; protein.
DR Bgee; ENSMUSG00000015980; Expressed in spermatid and 61 other tissues.
DR ExpressionAtlas; Q80YS5; baseline and differential.
DR Genevisible; Q80YS5; MM.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 3.
DR PROSITE; PS51450; LRR; 4.
PE 2: Evidence at transcript level;
KW Coiled coil; Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..523
FT /note="Leucine-rich repeat-containing protein 27"
FT /id="PRO_0000076243"
FT REPEAT 55..76
FT /note="LRR 1"
FT REPEAT 77..98
FT /note="LRR 2"
FT REPEAT 101..122
FT /note="LRR 3"
FT REPEAT 124..145
FT /note="LRR 4"
FT REPEAT 147..168
FT /note="LRR 5"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 372..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 503..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 335..374
FT /evidence="ECO:0000255"
FT COILED 463..494
FT /evidence="ECO:0000255"
FT COMPBIAS 372..386
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 523 AA; 59853 MW; 321D4E9C62198BDD CRC64;
MEDTSPQAVA EKAAKDPKAA KDLKDDAAAA TKSFPDHFSR EGDDQMDFEG VIFSSSPVLD
LSQRGLRHLG KFFKIPNLQQ LHLQRNLLRE IPEDFFQLLP NLTWLDLRYN KIKVLPSGIG
SHKHLKTLLL ERNPIKMLPV ELGQVTTLTA LNLRHCPLEF PPRLIVQKGL VAILTFLRIC
SVEKAFPGDE LLPEVSAPKM GSNDLQYPVL PLPRKGSPSE NSLNDPDQEK EKADFFPPME
RLDLSELRKS NAASEIWPSK EEIRRFWKLR QEIVENEQVE IQEKKLLAVE LPPNLKAALN
VKEKKHRKPW PAVRKRSTSF KGILPNLPSG YQNTVHANRM EDTHKAALQE LQEKETVLEQ
RRRDKRALQE WREQTQHMRT RRELSKLQPP HSNMMASKIP FATDLTDYEK MPVSPFGKVK
PSGEGTAQRP IEISASPLAE LEDKIKRHTQ QIRTRSFLGT NPMQDIKTAN QDLETTKKLQ
EELRKLKVEM TLNKDHPFPS FTGNLSLHPP ASQPQNIFFN TKS
