LRC28_HUMAN
ID LRC28_HUMAN Reviewed; 367 AA.
AC Q86X40; A8KA22; Q6UY49; Q6ZSS6;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Leucine-rich repeat-containing protein 28;
GN Name=LRRC28; ORFNames=UNQ436/PRO867;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Placenta, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q86X40-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86X40-2; Sequence=VSP_022393, VSP_022394;
CC Name=3;
CC IsoId=Q86X40-3; Sequence=VSP_022395;
CC -!- MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
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DR EMBL; AY358082; AAQ88449.1; -; mRNA.
DR EMBL; AK127177; BAC86870.1; -; mRNA.
DR EMBL; AK292887; BAF85576.1; -; mRNA.
DR EMBL; AC022819; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC037479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471101; EAX02243.1; -; Genomic_DNA.
DR EMBL; BC047306; AAH47306.1; -; mRNA.
DR CCDS; CCDS10380.1; -. [Q86X40-1]
DR CCDS; CCDS66873.1; -. [Q86X40-2]
DR RefSeq; NP_001271329.1; NM_001284400.2. [Q86X40-2]
DR RefSeq; NP_001308604.1; NM_001321675.1. [Q86X40-1]
DR RefSeq; NP_653199.2; NM_144598.4. [Q86X40-1]
DR RefSeq; XP_011519520.1; XM_011521218.2. [Q86X40-1]
DR AlphaFoldDB; Q86X40; -.
DR SMR; Q86X40; -.
DR BioGRID; 125824; 28.
DR IntAct; Q86X40; 5.
DR STRING; 9606.ENSP00000304923; -.
DR iPTMnet; Q86X40; -.
DR PhosphoSitePlus; Q86X40; -.
DR BioMuta; LRRC28; -.
DR DMDM; 74762458; -.
DR EPD; Q86X40; -.
DR jPOST; Q86X40; -.
DR MassIVE; Q86X40; -.
DR MaxQB; Q86X40; -.
DR PaxDb; Q86X40; -.
DR PeptideAtlas; Q86X40; -.
DR PRIDE; Q86X40; -.
DR ProteomicsDB; 70233; -. [Q86X40-1]
DR ProteomicsDB; 70234; -. [Q86X40-2]
DR ProteomicsDB; 70235; -. [Q86X40-3]
DR Antibodypedia; 29175; 110 antibodies from 18 providers.
DR DNASU; 123355; -.
DR Ensembl; ENST00000301981.8; ENSP00000304923.3; ENSG00000168904.15. [Q86X40-1]
DR Ensembl; ENST00000447360.6; ENSP00000404520.2; ENSG00000168904.15. [Q86X40-2]
DR GeneID; 123355; -.
DR KEGG; hsa:123355; -.
DR MANE-Select; ENST00000301981.8; ENSP00000304923.3; NM_144598.5; NP_653199.2.
DR UCSC; uc002bva.3; human. [Q86X40-1]
DR CTD; 123355; -.
DR DisGeNET; 123355; -.
DR GeneCards; LRRC28; -.
DR HGNC; HGNC:28355; LRRC28.
DR HPA; ENSG00000168904; Tissue enhanced (liver).
DR neXtProt; NX_Q86X40; -.
DR OpenTargets; ENSG00000168904; -.
DR PharmGKB; PA134864287; -.
DR VEuPathDB; HostDB:ENSG00000168904; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000157771; -.
DR HOGENOM; CLU_064321_1_0_1; -.
DR InParanoid; Q86X40; -.
DR OMA; LYHTCHR; -.
DR OrthoDB; 764594at2759; -.
DR PhylomeDB; Q86X40; -.
DR TreeFam; TF332379; -.
DR PathwayCommons; Q86X40; -.
DR SignaLink; Q86X40; -.
DR BioGRID-ORCS; 123355; 30 hits in 1074 CRISPR screens.
DR ChiTaRS; LRRC28; human.
DR GenomeRNAi; 123355; -.
DR Pharos; Q86X40; Tdark.
DR PRO; PR:Q86X40; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q86X40; protein.
DR Bgee; ENSG00000168904; Expressed in ileal mucosa and 140 other tissues.
DR ExpressionAtlas; Q86X40; baseline and differential.
DR Genevisible; Q86X40; HS.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00369; LRR_TYP; 6.
PE 2: Evidence at transcript level;
KW Alternative splicing; Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..367
FT /note="Leucine-rich repeat-containing protein 28"
FT /id="PRO_0000272298"
FT REPEAT 16..36
FT /note="LRR 1"
FT REPEAT 42..63
FT /note="LRR 2"
FT REPEAT 66..87
FT /note="LRR 3"
FT REPEAT 89..110
FT /note="LRR 4"
FT REPEAT 112..133
FT /note="LRR 5"
FT REPEAT 135..156
FT /note="LRR 6"
FT REPEAT 158..180
FT /note="LRR 7"
FT REPEAT 181..202
FT /note="LRR 8"
FT REPEAT 204..226
FT /note="LRR 9"
FT VAR_SEQ 1..128
FT /note="MASELCKTISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNS
FT LTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLR
FT ALRHLRLANNQLQFLPP -> MFMGIVAATDFIWLNCYNIDSFCLFQFIRMQFILILIL
FT VV (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_022395"
FT VAR_SEQ 291..310
FT /note="DLNFLSPISLPRSLLELLHC -> GRQLLVLWLTAAPPSVCRLLTC (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_022393"
FT VAR_SEQ 311..367
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_022394"
FT VARIANT 168
FT /note="R -> H (in dbSNP:rs11857384)"
FT /id="VAR_034084"
SQ SEQUENCE 367 AA; 41912 MW; C2B00E60BF74ADB0 CRC64;
MASELCKTIS VARLEKHKNL FLNYRNLHHF PLELLKDEGL QYLERLYMKR NSLTSLPENL
AQKLPNLVEL YLHSNNIVVV PEAIGSLVKL QCLDLSDNAL EIVCPEIGRL RALRHLRLAN
NQLQFLPPEV GDLKELQTLD ISTNRLLTLP ERLHMCLSLQ YLTVDRNRLW YVPRHLCQLP
SLNELSMAGN RLAFLPLDLG RSRELQYVYV DNNIHLKGLP SYLYNKVIGC SGCGAPIQVS
EVKLLSFSSG QRTVFLPAEV KAIGTEHDHV LPLQELAMRG LYHTYHSLLK DLNFLSPISL
PRSLLELLHC PLGHCHRCSE PMFTIVYPKL FPLRETPMAG LHQWKTTVSF VAYCCSTQCL
QTFDLLS
