LRC28_MOUSE
ID LRC28_MOUSE Reviewed; 367 AA.
AC Q3TX51; Q0VGR7; Q8BK43;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Leucine-rich repeat-containing protein 28;
GN Name=Lrrc28;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK077270; BAC36722.1; -; mRNA.
DR EMBL; AK159417; BAE35065.1; -; mRNA.
DR EMBL; BC086694; AAH86694.1; -; mRNA.
DR CCDS; CCDS21351.1; -.
DR RefSeq; NP_780333.3; NM_175124.5.
DR AlphaFoldDB; Q3TX51; -.
DR SMR; Q3TX51; -.
DR STRING; 10090.ENSMUSP00000052177; -.
DR PhosphoSitePlus; Q3TX51; -.
DR MaxQB; Q3TX51; -.
DR PaxDb; Q3TX51; -.
DR PRIDE; Q3TX51; -.
DR ProteomicsDB; 287266; -.
DR Antibodypedia; 29175; 110 antibodies from 18 providers.
DR DNASU; 67867; -.
DR Ensembl; ENSMUST00000053950; ENSMUSP00000052177; ENSMUSG00000030556.
DR GeneID; 67867; -.
DR KEGG; mmu:67867; -.
DR UCSC; uc009hin.2; mouse.
DR CTD; 123355; -.
DR MGI; MGI:1915689; Lrrc28.
DR VEuPathDB; HostDB:ENSMUSG00000030556; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000157771; -.
DR HOGENOM; CLU_064321_1_0_1; -.
DR InParanoid; Q3TX51; -.
DR OMA; LYHTCHR; -.
DR OrthoDB; 764594at2759; -.
DR PhylomeDB; Q3TX51; -.
DR TreeFam; TF332379; -.
DR BioGRID-ORCS; 67867; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Lrrc28; mouse.
DR PRO; PR:Q3TX51; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q3TX51; protein.
DR Bgee; ENSMUSG00000030556; Expressed in animal zygote and 225 other tissues.
DR ExpressionAtlas; Q3TX51; baseline and differential.
DR Genevisible; Q3TX51; MM.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00369; LRR_TYP; 6.
DR PROSITE; PS51450; LRR; 7.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..367
FT /note="Leucine-rich repeat-containing protein 28"
FT /id="PRO_0000272299"
FT REPEAT 16..36
FT /note="LRR 1"
FT REPEAT 42..63
FT /note="LRR 2"
FT REPEAT 66..87
FT /note="LRR 3"
FT REPEAT 89..111
FT /note="LRR 4"
FT REPEAT 112..133
FT /note="LRR 5"
FT REPEAT 135..156
FT /note="LRR 6"
FT REPEAT 158..180
FT /note="LRR 7"
FT REPEAT 181..202
FT /note="LRR 8"
FT REPEAT 204..226
FT /note="LRR 9"
FT CONFLICT 28..42
FT /note="HHFPLELLKDEGLQH -> QPLILQQ (in Ref. 2; AAH86694)"
FT /evidence="ECO:0000305"
FT CONFLICT 104..106
FT /note="CPE -> WPK (in Ref. 1; BAC36722)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 367 AA; 41735 MW; FD0E6D2CBF3D6685 CRC64;
MASEICKTIS VARLEKHKNL FLNYRNLHHF PLELLKDEGL QHLERLYMKR NSLTTLPENL
AQKLPNLVEL YLHSNNIVVV PEAIGSLVKL QCLDLSDNAL EIVCPEIGGL RALRHLRLAN
NQLQFLPPEV GDLKELQTLD ISSNRLLALP ERLHLCLSLQ YLTVDRNRLC CVPRHLCQLP
SLNELSMAGN HLASLPIDLG RSRELQYVYV DNNIQLKGLP SYLYNKVIGC NGCGIPIQLS
EVRLLTFSSG QLTVFLPAEV KTIGTEKDHV LPLQELTMRS LYRTYHGLWK DLNFLSPISL
PRSLLELLHC PLGHCHLCSE PMFTFVYPKI FPLRETPMAG LHQRRTSIGF VAYCCSTQCL
RTFNLLC
