LRC29_HUMAN
ID LRC29_HUMAN Reviewed; 223 AA.
AC Q8WV35; B2RE92; Q9UKA0;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Leucine-rich repeat-containing protein 29;
DE AltName: Full=F-box and leucine-rich repeat protein 9;
DE AltName: Full=F-box protein FBL9;
DE AltName: Full=F-box/LRR-repeat protein 9;
GN Name=LRRC29; Synonyms=FBL9, FBXL9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=10531037; DOI=10.1016/s0960-9822(00)80021-4;
RA Winston J.T., Koepp D.M., Zhu C., Elledge S.J., Harper J.W.;
RT "A family of mammalian F-box proteins.";
RL Curr. Biol. 9:1180-1182(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Retina;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probably recognizes and binds to some phosphorylated proteins
CC and promotes their ubiquitination and degradation.
CC -!- SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q8WV35; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-10276755, EBI-10173507;
CC Q8WV35; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-10276755, EBI-3867333;
CC Q8WV35; O75031: HSF2BP; NbExp=3; IntAct=EBI-10276755, EBI-7116203;
CC Q8WV35; O76011: KRT34; NbExp=3; IntAct=EBI-10276755, EBI-1047093;
CC Q8WV35; Q8N720: ZNF655; NbExp=3; IntAct=EBI-10276755, EBI-625509;
CC Q8WV35; A8K5H9; NbExp=3; IntAct=EBI-10276755, EBI-10174421;
CC -!- TISSUE SPECIFICITY: Expressed in heart, kidney, liver, lung and
CC pancreas. {ECO:0000269|PubMed:10531037}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF03701.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF176701; AAF03701.1; ALT_FRAME; mRNA.
DR EMBL; AK316602; BAG38189.1; -; mRNA.
DR EMBL; CH471092; EAW83099.1; -; Genomic_DNA.
DR EMBL; BC018785; AAH18785.1; -; mRNA.
DR RefSeq; NP_001004055.1; NM_001004055.1.
DR RefSeq; NP_036295.1; NM_012163.2.
DR RefSeq; XP_016878620.1; XM_017023131.1.
DR RefSeq; XP_016878621.1; XM_017023132.1.
DR RefSeq; XP_016878622.1; XM_017023133.1.
DR RefSeq; XP_016878623.1; XM_017023134.1.
DR AlphaFoldDB; Q8WV35; -.
DR SMR; Q8WV35; -.
DR BioGRID; 117622; 38.
DR IntAct; Q8WV35; 7.
DR STRING; 9606.ENSP00000387318; -.
DR iPTMnet; Q8WV35; -.
DR PhosphoSitePlus; Q8WV35; -.
DR BioMuta; LRRC29; -.
DR DMDM; 38257689; -.
DR PaxDb; Q8WV35; -.
DR PRIDE; Q8WV35; -.
DR ProteomicsDB; 74742; -.
DR DNASU; 26231; -.
DR GeneID; 26231; -.
DR UCSC; uc002esd.4; human.
DR CTD; 26231; -.
DR DisGeNET; 26231; -.
DR GeneCards; LRRC29; -.
DR HGNC; HGNC:13605; LRRC29.
DR neXtProt; NX_Q8WV35; -.
DR PharmGKB; PA28029; -.
DR VEuPathDB; HostDB:ENSG00000125122; -.
DR eggNOG; KOG1947; Eukaryota.
DR HOGENOM; CLU_063469_0_1_1; -.
DR InParanoid; Q8WV35; -.
DR OMA; MCSGINV; -.
DR OrthoDB; 315988at2759; -.
DR PhylomeDB; Q8WV35; -.
DR PathwayCommons; Q8WV35; -.
DR SignaLink; Q8WV35; -.
DR BioGRID-ORCS; 26231; 7 hits in 1108 CRISPR screens.
DR ChiTaRS; LRRC29; human.
DR GenomeRNAi; 26231; -.
DR Pharos; Q8WV35; Tdark.
DR PRO; PR:Q8WV35; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q8WV35; protein.
DR Genevisible; Q8WV35; HS.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13516; LRR_6; 1.
DR SMART; SM00367; LRR_CC; 5.
PE 1: Evidence at protein level;
KW Leucine-rich repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT CHAIN 1..223
FT /note="Leucine-rich repeat-containing protein 29"
FT /id="PRO_0000119852"
FT REPEAT 27..48
FT /note="LRR 1"
FT REPEAT 56..84
FT /note="LRR 2"
FT REPEAT 85..109
FT /note="LRR 3"
FT REPEAT 110..135
FT /note="LRR 4"
FT DOMAIN 134..181
FT /note="F-box"
FT REPEAT 136..161
FT /note="LRR 5"
FT REPEAT 162..187
FT /note="LRR 6"
FT REPEAT 188..213
FT /note="LRR 7"
FT VARIANT 75
FT /note="R -> Q (in dbSNP:rs3743728)"
FT /id="VAR_049031"
FT VARIANT 117
FT /note="G -> S (in dbSNP:rs34595673)"
FT /id="VAR_049032"
SQ SEQUENCE 223 AA; 23797 MW; ADFBA9EC878BE46D CRC64;
MYSSGWPAGA AEPRHGRGRE LAQALGCMHG APSQLASLSL AHCSSLKSRP ELEHQASGTK
DACPEPQGPS LLTLRALQEL DLTACSKLTD ASLAKVLQFL QLRQLSLSLL PELTDNGLVA
VARGCPSLEH LALSHCSRLS DKGWAQAASS WPRLQHLNLS SCSQLIEQTL DAIGQACRQL
RVLDVATCPG INMAAVRRFQ AQLPQVSCVQ SRFVGGADLT LTL
