ID   LRC30_HUMAN             Reviewed;         301 AA.
AC   A6NM36;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Leucine-rich repeat-containing protein 30;
GN   Name=LRRC30;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16177791; DOI=10.1038/nature03983;
RA   Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA   Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA   Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA   Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA   Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA   Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA   Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA   Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 18.";
RL   Nature 437:551-555(2005).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP005270; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS42409.1; -.
DR   RefSeq; NP_001099051.1; NM_001105581.1.
DR   AlphaFoldDB; A6NM36; -.
DR   SMR; A6NM36; -.
DR   STRING; 9606.ENSP00000372959; -.
DR   iPTMnet; A6NM36; -.
DR   PhosphoSitePlus; A6NM36; -.
DR   BioMuta; LRRC30; -.
DR   PaxDb; A6NM36; -.
DR   PeptideAtlas; A6NM36; -.
DR   PRIDE; A6NM36; -.
DR   Antibodypedia; 66148; 7 antibodies from 6 providers.
DR   DNASU; 339291; -.
DR   Ensembl; ENST00000383467.3; ENSP00000372959.2; ENSG00000206422.3.
DR   GeneID; 339291; -.
DR   KEGG; hsa:339291; -.
DR   MANE-Select; ENST00000383467.3; ENSP00000372959.2; NM_001105581.3; NP_001099051.1.
DR   UCSC; uc010wzk.3; human.
DR   CTD; 339291; -.
DR   GeneCards; LRRC30; -.
DR   HGNC; HGNC:30219; LRRC30.
DR   HPA; ENSG00000206422; Group enriched (skeletal muscle, tongue).
DR   neXtProt; NX_A6NM36; -.
DR   OpenTargets; ENSG00000206422; -.
DR   PharmGKB; PA134945901; -.
DR   VEuPathDB; HostDB:ENSG00000206422; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   GeneTree; ENSGT00940000161019; -.
DR   HOGENOM; CLU_000288_18_15_1; -.
DR   InParanoid; A6NM36; -.
DR   OMA; FVQIPLC; -.
DR   OrthoDB; 484111at2759; -.
DR   PhylomeDB; A6NM36; -.
DR   TreeFam; TF333627; -.
DR   SignaLink; A6NM36; -.
DR   BioGRID-ORCS; 339291; 3 hits in 1059 CRISPR screens.
DR   GenomeRNAi; 339291; -.
DR   Pharos; A6NM36; Tdark.
DR   PRO; PR:A6NM36; -.
DR   Proteomes; UP000005640; Chromosome 18.
DR   RNAct; A6NM36; protein.
DR   Bgee; ENSG00000206422; Expressed in skeletal muscle tissue and 12 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0004722; F:protein serine/threonine phosphatase activity; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13855; LRR_8; 1.
DR   SMART; SM00369; LRR_TYP; 6.
DR   PROSITE; PS51450; LRR; 8.
PE   4: Predicted;
KW   Leucine-rich repeat; Reference proteome; Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000305"
FT   CHAIN           2..301
FT                   /note="Leucine-rich repeat-containing protein 30"
FT                   /id="PRO_0000310986"
FT   REPEAT          72..93
FT                   /note="LRR 1"
FT   REPEAT          95..116
FT                   /note="LRR 2"
FT   REPEAT          118..139
FT                   /note="LRR 3"
FT   REPEAT          141..163
FT                   /note="LRR 4"
FT   REPEAT          164..185
FT                   /note="LRR 5"
FT   REPEAT          187..208
FT                   /note="LRR 6"
FT   REPEAT          210..231
FT                   /note="LRR 7"
FT   REPEAT          233..254
FT                   /note="LRR 8"
FT   REPEAT          265..287
FT                   /note="LRR 9"
SQ   SEQUENCE   301 AA;  34034 MW;  42070AA183AB3FCE CRC64;
     MGARQSRASS KDKGPKRMLF TGRRQKFSPW DDALLSGRDP RSLLKRGMHH VSFSLVTRGM
     TDIPDFLWGL SEVQKLNLSH NQLRVLPPEV GKLTRIVVLN LCGNRLKSLP REVSLLQCLK
     VLFVNMNCLT EVPAELSLCR KLEVLSLSHN CLSQLPACFA DLSRLRKLNL SNNFFAHIPM
     CVFSLKELIF LHVGSNRLEN IAESIQHLAS LQIFIAEGNN IHSFPRSLCL VTSLELLNLN
     NNDIQTLPSE LHLLCRLVRI AWNPMDKGLH ISHNPLSKPL PELVEGGLEM LFGYLKDKKH
     T