LRC31_HUMAN
ID LRC31_HUMAN Reviewed; 552 AA.
AC Q6UY01; B7ZL44; E5RJA9; Q17RA3; Q8N848; Q9H5N5; V9HW14;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Leucine-rich repeat-containing protein 31;
GN Name=LRRC31; ORFNames=UNQ9367/PRO34156;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Li J.Y., Wang H.Y., Liu F.J., Liu J.;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Colon, and Stomach;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q6UY01-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6UY01-2; Sequence=VSP_017797;
CC Name=3;
CC IsoId=Q6UY01-3; Sequence=VSP_017798, VSP_017799;
CC Name=4;
CC IsoId=Q6UY01-4; Sequence=VSP_055910, VSP_055911;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB15589.1; Type=Frameshift; Evidence={ECO:0000305};
CC -!- SEQUENCE CAUTION: [Isoform 2]:
CC Sequence=BAB15589.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; EU668335; ACF94488.1; -; mRNA.
DR EMBL; AY358138; AAQ88505.1; -; mRNA.
DR EMBL; AK026912; BAB15589.1; ALT_FRAME; mRNA.
DR EMBL; AK097338; BAC05004.1; -; mRNA.
DR EMBL; AC078795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC117401; AAI17402.1; -; mRNA.
DR EMBL; BC143569; AAI43570.1; -; mRNA.
DR EMBL; BC143582; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS43167.1; -. [Q6UY01-1]
DR CCDS; CCDS63832.1; -. [Q6UY01-2]
DR CCDS; CCDS63833.1; -. [Q6UY01-4]
DR RefSeq; NP_001264056.1; NM_001277127.1. [Q6UY01-4]
DR RefSeq; NP_001264057.1; NM_001277128.1. [Q6UY01-2]
DR RefSeq; NP_079003.2; NM_024727.3. [Q6UY01-1]
DR RefSeq; XP_011511462.1; XM_011513160.2. [Q6UY01-3]
DR AlphaFoldDB; Q6UY01; -.
DR SMR; Q6UY01; -.
DR BioGRID; 122882; 244.
DR IntAct; Q6UY01; 5.
DR STRING; 9606.ENSP00000325978; -.
DR iPTMnet; Q6UY01; -.
DR PhosphoSitePlus; Q6UY01; -.
DR BioMuta; LRRC31; -.
DR DMDM; 74762376; -.
DR EPD; Q6UY01; -.
DR jPOST; Q6UY01; -.
DR MassIVE; Q6UY01; -.
DR MaxQB; Q6UY01; -.
DR PaxDb; Q6UY01; -.
DR PeptideAtlas; Q6UY01; -.
DR PRIDE; Q6UY01; -.
DR ProteomicsDB; 16544; -.
DR ProteomicsDB; 67686; -. [Q6UY01-1]
DR ProteomicsDB; 67687; -. [Q6UY01-2]
DR ProteomicsDB; 67688; -. [Q6UY01-3]
DR Antibodypedia; 51015; 39 antibodies from 10 providers.
DR DNASU; 79782; -.
DR Ensembl; ENST00000264676.9; ENSP00000264676.5; ENSG00000114248.10. [Q6UY01-2]
DR Ensembl; ENST00000316428.10; ENSP00000325978.5; ENSG00000114248.10. [Q6UY01-1]
DR Ensembl; ENST00000523069.1; ENSP00000429145.1; ENSG00000114248.10. [Q6UY01-4]
DR GeneID; 79782; -.
DR KEGG; hsa:79782; -.
DR MANE-Select; ENST00000316428.10; ENSP00000325978.5; NM_024727.4; NP_079003.2.
DR UCSC; uc003fgc.3; human. [Q6UY01-1]
DR CTD; 79782; -.
DR DisGeNET; 79782; -.
DR GeneCards; LRRC31; -.
DR HGNC; HGNC:26261; LRRC31.
DR HPA; ENSG00000114248; Tissue enhanced (intestine, salivary gland, stomach).
DR neXtProt; NX_Q6UY01; -.
DR OpenTargets; ENSG00000114248; -.
DR PharmGKB; PA134985943; -.
DR VEuPathDB; HostDB:ENSG00000114248; -.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00730000111293; -.
DR HOGENOM; CLU_036052_1_0_1; -.
DR InParanoid; Q6UY01; -.
DR OMA; SCNKEIG; -.
DR OrthoDB; 463420at2759; -.
DR PhylomeDB; Q6UY01; -.
DR TreeFam; TF331228; -.
DR PathwayCommons; Q6UY01; -.
DR SignaLink; Q6UY01; -.
DR BioGRID-ORCS; 79782; 8 hits in 1064 CRISPR screens.
DR ChiTaRS; LRRC31; human.
DR GenomeRNAi; 79782; -.
DR Pharos; Q6UY01; Tdark.
DR PRO; PR:Q6UY01; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q6UY01; protein.
DR Bgee; ENSG00000114248; Expressed in rectum and 51 other tissues.
DR ExpressionAtlas; Q6UY01; baseline and differential.
DR Genevisible; Q6UY01; HS.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR042419; LRC31.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24109; PTHR24109; 1.
DR Pfam; PF13516; LRR_6; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..552
FT /note="Leucine-rich repeat-containing protein 31"
FT /id="PRO_0000229922"
FT REPEAT 227..246
FT /note="LRR 1"
FT REPEAT 255..275
FT /note="LRR 2"
FT REPEAT 283..293
FT /note="LRR 3"
FT REPEAT 311..331
FT /note="LRR 4"
FT REPEAT 339..360
FT /note="LRR 5"
FT REPEAT 367..387
FT /note="LRR 6"
FT REPEAT 395..415
FT /note="LRR 7"
FT REPEAT 423..443
FT /note="LRR 8"
FT REPEAT 453..475
FT /note="LRR 9"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 107..162
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_017797"
FT VAR_SEQ 331..346
FT /note="TQVIPLLSNLQELDLS -> NSYLSIWENGKNSRLS (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_017798"
FT VAR_SEQ 347..552
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_017799"
FT VAR_SEQ 443
FT /note="A -> E (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_055910"
FT VAR_SEQ 444..552
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_055911"
FT VARIANT 322
FT /note="L -> F (in dbSNP:rs35923425)"
FT /id="VAR_034085"
FT VARIANT 324
FT /note="A -> E (in dbSNP:rs3732452)"
FT /id="VAR_051111"
FT VARIANT 378
FT /note="L -> F (in dbSNP:rs35923425)"
FT /id="VAR_051112"
FT CONFLICT 412
FT /note="K -> E (in Ref. 3; BAB15589)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 552 AA; 61489 MW; 27821051D1157502 CRC64;
MSQTRKKTSS EGETKPQTST VNKFLRGSNA ESRKEDNDLK TSDSQPSDWI QKTATSETAK
PLSSEMEWRS SMEKNEHFLQ KLGKKAVNKC LDLNNCGLTT ADMKEMVALL PFLPDLEELD
ISWNGFVGGT LLSITQQMHL VSKLKILRLG SCRLTTDDVQ ALGEAFEMIP ELEELNLSWN
SKVGGNLPLI LQKFQKGSKI QMIELVDCSL TSEDGTFLGQ LLPMLQSLEV LDLSINRDIV
GSLNSIAQGL KSTSNLKVLK LHSCGLSQKS VKILDAAFRY LGELRKLDLS CNKDLGGGFE
DSPAQLVMLK HLQVLDLHQC SLTADDVMSL TQVIPLLSNL QELDLSANKK MGSSSENLLS
RLRFLPALKS LVINNCALES ETFTALAEAS VHLSALEVFN LSWNKCVGGN LKLLLETLKL
SMSLQVLRLS SCSLVTEDVA LLASVIQTGH LAKLQKLDLS YNDSICDAGW TMFCQNVRFL
KELIELDISL RPSNFRDCGQ WFRHLLYAVT KLPQITEIGM KRWILPASQE EELECFDQDK
KRSIHFDHGG FQ
