ID   LRC34_RAT               Reviewed;         415 AA.
AC   Q4V8D9;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Leucine-rich repeat-containing protein 34;
GN   Name=Lrrc34;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Highly expressed in stem cells where it may be involved in
CC       regulation of pluripotency. In embryonic stem cells (ESCs), important
CC       for normal expression of the pluripotency regulators POU5F1/OCT4 and
CC       KLF4. Also important for expression of the ectodermal marker gene NES
CC       and the endodermal marker gene GATA4. Promotes stem cell proliferation
CC       in vitro. {ECO:0000250|UniProtKB:Q9DAM1}.
CC   -!- SUBUNIT: Interacts with NPM1 and NCL. {ECO:0000250|UniProtKB:Q9DAM1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9DAM1}. Nucleus,
CC       nucleolus {ECO:0000250|UniProtKB:Q9DAM1}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9DAM1}. Note=As stem cells differentiate,
CC       translocates from the nucleolus to the nucleus and then to the
CC       cytoplasm. Colocalizes with NPM1 and NCL in the nucleolus.
CC       {ECO:0000250|UniProtKB:Q9DAM1}.
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DR   EMBL; BC097432; AAH97432.1; -; mRNA.
DR   RefSeq; NP_001038161.1; NM_001044696.1.
DR   AlphaFoldDB; Q4V8D9; -.
DR   SMR; Q4V8D9; -.
DR   STRING; 10116.ENSRNOP00000033262; -.
DR   iPTMnet; Q4V8D9; -.
DR   PhosphoSitePlus; Q4V8D9; -.
DR   PaxDb; Q4V8D9; -.
DR   PRIDE; Q4V8D9; -.
DR   GeneID; 499589; -.
DR   KEGG; rno:499589; -.
DR   UCSC; RGD:1565052; rat.
DR   CTD; 151827; -.
DR   RGD; 1565052; Lrrc34.
DR   eggNOG; KOG4308; Eukaryota.
DR   InParanoid; Q4V8D9; -.
DR   PhylomeDB; Q4V8D9; -.
DR   PRO; PR:Q4V8D9; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13516; LRR_6; 6.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Differentiation; Leucine-rich repeat; Nucleus;
KW   Reference proteome; Repeat.
FT   CHAIN           1..415
FT                   /note="Leucine-rich repeat-containing protein 34"
FT                   /id="PRO_0000228671"
FT   REPEAT          246..272
FT                   /note="LRR 1"
FT   REPEAT          274..296
FT                   /note="LRR 2"
SQ   SEQUENCE   415 AA;  46469 MW;  A2D921F09F1F46A7 CRC64;
     MEKLQDQYSF LCSENIRKTN PLILNILQKL DEEIEKRPKE KITVNIAGNS RLDSGQRITS
     EDFWLLSKAL RNHPCIGGVD VRYNLIGDVG AYYAAKLLQK QPNITYLNLM FNDIGPEGGE
     LIAKALQKNK TLKYLRMTGN KIENTGGMLF AAMLQMNSSL EKLDLGDCDL GLQSVIAFST
     VLTQNKAIKG INLNRPILYG EQEESTVHIG HMSKQNHVLV ELHMCKHGMK NYGIQQLCNA
     LHSNSTLRYL DVSCNKITRD GMVFLADVLK SNSTLEVLDL SFNRIENAGA KYLSETLTSH
     NRSLKALSVV SNKIEGEGLV ALSQSMNTNL VLSNIYIWGN KFDEDTCVAY SNLIESGRLK
     PENTDVEPYV VDEHIYLSEV SNGLKRHYYW TPTYGECYVP SSSAGFALVP VGERL