LRC36_HUMAN
ID LRC36_HUMAN Reviewed; 754 AA.
AC Q1X8D7; A4FTV6; A6NDE9; A8K8E6; B7Z7B3; Q7Z5K5;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Leucine-rich repeat-containing protein 36;
DE AltName: Full=ROR gamma-binding protein 70;
GN Name=LRRC36; Synonyms=RORBP70;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RA Fang X., Wang H., Xu Z.Y., Yin L.L., Xu M., Li J.M., Zhou Z.M.;
RT "Cloning of a different splice of Homo sapiens hypothetical protein
RT FLJ11004 (FLJ11004).";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Kim Y.-S., Jetten A.M.;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q1X8D7; Q8IYF3-3: TEX11; NbExp=3; IntAct=EBI-12218159, EBI-11523345;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q1X8D7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q1X8D7-2; Sequence=VSP_022963, VSP_022964;
CC Name=3;
CC IsoId=Q1X8D7-3; Sequence=VSP_057264, VSP_057265, VSP_057266;
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DR EMBL; AY313780; AAP81011.1; -; mRNA.
DR EMBL; AY963267; AAY46032.1; -; mRNA.
DR EMBL; AK292311; BAF85000.1; -; mRNA.
DR EMBL; AK301766; BAH13549.1; -; mRNA.
DR EMBL; AC009061; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471092; EAW83126.1; -; Genomic_DNA.
DR EMBL; BC026156; AAH26156.2; -; mRNA.
DR CCDS; CCDS32467.1; -. [Q1X8D7-1]
DR CCDS; CCDS58474.1; -. [Q1X8D7-2]
DR RefSeq; NP_001155047.1; NM_001161575.1. [Q1X8D7-2]
DR RefSeq; NP_060766.5; NM_018296.5. [Q1X8D7-1]
DR AlphaFoldDB; Q1X8D7; -.
DR SMR; Q1X8D7; -.
DR BioGRID; 120570; 14.
DR IntAct; Q1X8D7; 10.
DR STRING; 9606.ENSP00000329943; -.
DR iPTMnet; Q1X8D7; -.
DR PhosphoSitePlus; Q1X8D7; -.
DR BioMuta; LRRC36; -.
DR DMDM; 209572645; -.
DR jPOST; Q1X8D7; -.
DR MassIVE; Q1X8D7; -.
DR PaxDb; Q1X8D7; -.
DR PeptideAtlas; Q1X8D7; -.
DR PRIDE; Q1X8D7; -.
DR ProteomicsDB; 61251; -. [Q1X8D7-1]
DR ProteomicsDB; 61252; -. [Q1X8D7-2]
DR ProteomicsDB; 6849; -.
DR TopDownProteomics; Q1X8D7-2; -. [Q1X8D7-2]
DR Antibodypedia; 56057; 84 antibodies from 14 providers.
DR DNASU; 55282; -.
DR Ensembl; ENST00000329956.11; ENSP00000329943.6; ENSG00000159708.18. [Q1X8D7-1]
DR Ensembl; ENST00000435835.3; ENSP00000411122.3; ENSG00000159708.18. [Q1X8D7-3]
DR Ensembl; ENST00000563189.5; ENSP00000455103.1; ENSG00000159708.18. [Q1X8D7-2]
DR GeneID; 55282; -.
DR KEGG; hsa:55282; -.
DR MANE-Select; ENST00000329956.11; ENSP00000329943.6; NM_018296.6; NP_060766.5.
DR UCSC; uc002esv.4; human. [Q1X8D7-1]
DR CTD; 55282; -.
DR DisGeNET; 55282; -.
DR GeneCards; LRRC36; -.
DR HGNC; HGNC:25615; LRRC36.
DR HPA; ENSG00000159708; Tissue enriched (testis).
DR neXtProt; NX_Q1X8D7; -.
DR OpenTargets; ENSG00000159708; -.
DR PharmGKB; PA142671524; -.
DR VEuPathDB; HostDB:ENSG00000159708; -.
DR eggNOG; ENOG502S998; Eukaryota.
DR GeneTree; ENSGT00530000063884; -.
DR HOGENOM; CLU_021289_0_0_1; -.
DR InParanoid; Q1X8D7; -.
DR OMA; VVPNDME; -.
DR OrthoDB; 881430at2759; -.
DR PhylomeDB; Q1X8D7; -.
DR TreeFam; TF338646; -.
DR PathwayCommons; Q1X8D7; -.
DR SignaLink; Q1X8D7; -.
DR BioGRID-ORCS; 55282; 12 hits in 1061 CRISPR screens.
DR ChiTaRS; LRRC36; human.
DR GenomeRNAi; 55282; -.
DR Pharos; Q1X8D7; Tdark.
DR PRO; PR:Q1X8D7; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q1X8D7; protein.
DR Bgee; ENSG00000159708; Expressed in left testis and 131 other tissues.
DR ExpressionAtlas; Q1X8D7; baseline and differential.
DR Genevisible; Q1X8D7; HS.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR PROSITE; PS51450; LRR; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Leucine-rich repeat; Reference proteome;
KW Repeat.
FT CHAIN 1..754
FT /note="Leucine-rich repeat-containing protein 36"
FT /id="PRO_0000275855"
FT REPEAT 51..72
FT /note="LRR 1"
FT REPEAT 73..94
FT /note="LRR 2"
FT DOMAIN 107..146
FT /note="LRRCT"
FT REGION 241..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 600..680
FT /evidence="ECO:0000255"
FT COMPBIAS 241..258
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..121
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.1"
FT /id="VSP_022963"
FT VAR_SEQ 1..9
FT /note="MAEQWELDE -> MLRPRFLPP (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_057264"
FT VAR_SEQ 10..130
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_057265"
FT VAR_SEQ 122..130
FT /note="YTLQTLEKL -> MLRPRFLPP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.1"
FT /id="VSP_022964"
FT VAR_SEQ 499..602
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_057266"
FT VARIANT 222
FT /note="R -> P (in dbSNP:rs9922085)"
FT /id="VAR_047015"
FT VARIANT 509
FT /note="G -> S (in dbSNP:rs8052655)"
FT /id="VAR_047016"
FT VARIANT 744
FT /note="S -> G (in dbSNP:rs16957415)"
FT /id="VAR_047017"
FT CONFLICT 43
FT /note="G -> S (in Ref. 2; AAY46032 and 6; AAH26156)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 754 AA; 83823 MW; E7AD1F4151F340D2 CRC64;
MAEQWELDEE GIRRLGALTL EQPELVESLS LQGSYAGKIH SIGDAFRNFK NLRSLDLSRN
LITSLKGIQY LCSLQDLNLY YNNIPSLVEV SRLQPLPFLK ELDLRLNPVV RKDTDYRLFA
VYTLQTLEKL DDRTVREGER KAAKLHFSQL GNSENFLLEV EKSSREKTMK NCVTGESSAS
KVSANVDSRI EMDSNKGLFI PFPNREIKDS LSTSATQGNG TRDQKLDTFP LGTQTQEVAR
REMPSDNHQE DEFRHYSPRQ STVRSPEKMT REGYQVSFLD NKSSGSSPEK ELIPKPDTFH
LTHDASLSKC LDVGDSSQIH PYQLPSDVGL ENYDSCYSQT LSLHGSLGKR PQRSKNYQEY
SIKPSNDIKT TASHSCGDLL TSLSNPDSST GRLLKLSSDL YATTHFNSDP AVLVNVEQQL
STSLDDLTPA HGSVPNNAVL GNRTTPLRTL LLSPGTSEHR KIFTKRSLSP SKRGFKWKDN
ILANLNLKHG FQDATGSEPL SSDLGSLHGL AGNHSPPISA RTPHVATVLR QLLELVDKHW
NGSGSLLLNK KFLGPARDLL LSLVVPAPSQ PRCCSHPEDT MKAFCRRELE LKEAAQLVPN
DMESLKQKLV RVLEENLILS EKIQQLEEGA AISIVSGQQS HTYDDLLHKN QQLTMQVACL
NQELAQLKKL EKTVAILHES QRSLVVTNEY LLQQLNKEPK GYSGKALLPP EKGHHLGRSS
PFGKSTLSSS SPVAHETGQY LIQSVLDAAP EPGL
