LRC36_MOUSE
ID LRC36_MOUSE Reviewed; 755 AA.
AC Q3V0M2; B2RX53;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Leucine-rich repeat-containing protein 36;
GN Name=Lrrc36;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3V0M2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3V0M2-2; Sequence=VSP_022965, VSP_022966;
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DR EMBL; AC090480; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK133042; BAE21482.1; -; mRNA.
DR EMBL; BC150957; AAI50958.1; -; mRNA.
DR CCDS; CCDS22601.1; -. [Q3V0M2-2]
DR RefSeq; NP_001028543.1; NM_001033371.3. [Q3V0M2-2]
DR RefSeq; NP_001164260.1; NM_001170789.1.
DR RefSeq; XP_006531118.1; XM_006531055.2. [Q3V0M2-1]
DR AlphaFoldDB; Q3V0M2; -.
DR SMR; Q3V0M2; -.
DR STRING; 10090.ENSMUSP00000066345; -.
DR iPTMnet; Q3V0M2; -.
DR PhosphoSitePlus; Q3V0M2; -.
DR MaxQB; Q3V0M2; -.
DR PaxDb; Q3V0M2; -.
DR PRIDE; Q3V0M2; -.
DR ProteomicsDB; 290150; -. [Q3V0M2-1]
DR ProteomicsDB; 290151; -. [Q3V0M2-2]
DR Antibodypedia; 56057; 84 antibodies from 14 providers.
DR Ensembl; ENSMUST00000067305; ENSMUSP00000066345; ENSMUSG00000054320. [Q3V0M2-2]
DR Ensembl; ENSMUST00000213547; ENSMUSP00000150103; ENSMUSG00000054320. [Q3V0M2-1]
DR GeneID; 270091; -.
DR KEGG; mmu:270091; -.
DR UCSC; uc009nda.2; mouse. [Q3V0M2-2]
DR CTD; 55282; -.
DR MGI; MGI:2448585; Lrrc36.
DR VEuPathDB; HostDB:ENSMUSG00000054320; -.
DR eggNOG; ENOG502S998; Eukaryota.
DR GeneTree; ENSGT00530000063884; -.
DR InParanoid; Q3V0M2; -.
DR PhylomeDB; Q3V0M2; -.
DR TreeFam; TF338646; -.
DR BioGRID-ORCS; 270091; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Lrrc36; mouse.
DR PRO; PR:Q3V0M2; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q3V0M2; protein.
DR Bgee; ENSMUSG00000054320; Expressed in seminiferous tubule of testis and 45 other tissues.
DR ExpressionAtlas; Q3V0M2; baseline and differential.
DR Genevisible; Q3V0M2; MM.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR PROSITE; PS51450; LRR; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Leucine-rich repeat; Reference proteome;
KW Repeat.
FT CHAIN 1..755
FT /note="Leucine-rich repeat-containing protein 36"
FT /id="PRO_0000275856"
FT REPEAT 51..72
FT /note="LRR 1"
FT REPEAT 73..94
FT /note="LRR 2"
FT DOMAIN 107..146
FT /note="LRRCT"
FT REGION 354..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 601..671
FT /evidence="ECO:0000255"
FT COMPBIAS 486..517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..749
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..121
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_022965"
FT VAR_SEQ 122..130
FT /note="YTLQTLEKL -> MLTPWLSPP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_022966"
SQ SEQUENCE 755 AA; 83763 MW; 552E801708212482 CRC64;
MAEQWDLDEE CLRRLGALTL EQPELVESLS LQGSYAGKIH SIGDAFRNFK SLRSLDLSRN
LITSLKGIQY LCSLQELNLY YNNIPSLVEV SRLQPLPFLK ELDLRLNPVV RKDTDYRLFA
VYTLQTLEKL DDRAVRDSER RAAKLHFSQL GNSENFLLEV EKSSREKTMK NCVTDEGPAS
HVSPEVDARM ETDANKGLFI PFPNREIKDS LTSICAAQGS GTPAQKLDVF PLGTQMQEAT
RRETSDLHQE DELRLYPPPQ STVRSPEKMT RDGYRVSFLD TKSSGSSPEK DLIPKPDAYP
CTHDASLGKR LDVGDSNQIL PCQLPSEVCL DHYGNQYSQT LCLHGSLVKR AQKGKNYREH
SIKPSQDKKA TTSHPCGDLL TSLSNPDSST GRLLRLSSDL YATTHFNSDP ALLANVEQQL
SSLRDFTPAP GSFPSSPALG NSLRTLLLPP GTPENREIPT KRSLSPSRRG FKRKDGILAN
PSLKRGFQDA TGSEAQPLSS DLGSLHGLSG NHSPPISART PHVATVLRQL LELVDKHWNG
SGSLLLDKKF LGPARDLLLS LVVPAPSQQW RRSKLDDKAG KALCWRETEL KEAGLLVPND
VESLKQKLVK VLEENLVLSE KIQQLEGTAA TSIVSGHPSH THDELLRKNQ QLTIQVACLT
QELTQLKRLE ETVALLHESQ RSLVVTNEYL LQQLHKEQKG YSGKSLLPPE KSHPLGRSSP
FGKSTLSSSS PMVHDTGQYL IQSVSEADPE PSLWS
