LRC38_MOUSE
ID LRC38_MOUSE Reviewed; 298 AA.
AC A2VDH3; A2A8J4; Q3TVH8; Q8BR15;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Leucine-rich repeat-containing protein 38;
DE AltName: Full=BK channel auxiliary gamma subunit LRRC38;
DE Flags: Precursor;
GN Name=Lrrc38;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 11-298.
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Auxiliary protein of the large-conductance, voltage and
CC calcium-activated potassium channel (BK alpha). Modulates gating
CC properties by producing a marked shift in the BK channel's voltage
CC dependence of activation in the hyperpolarizing direction, and in the
CC absence of calcium (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with KCNMA1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- DOMAIN: The transmembrane domain is necessary for interaction with
CC KCNMA1. {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI29964.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL611982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC129963; AAI29964.1; ALT_INIT; mRNA.
DR EMBL; AK045936; BAC32537.1; -; mRNA.
DR EMBL; AK160116; BAE35640.1; -; mRNA.
DR CCDS; CCDS51351.1; -.
DR RefSeq; NP_001156455.1; NM_001162983.1.
DR AlphaFoldDB; A2VDH3; -.
DR SMR; A2VDH3; -.
DR STRING; 10090.ENSMUSP00000053597; -.
DR GlyGen; A2VDH3; 1 site.
DR PaxDb; A2VDH3; -.
DR PRIDE; A2VDH3; -.
DR ProteomicsDB; 290152; -.
DR Antibodypedia; 48140; 73 antibodies from 14 providers.
DR Ensembl; ENSMUST00000052458; ENSMUSP00000053597; ENSMUSG00000028584.
DR GeneID; 242735; -.
DR KEGG; mmu:242735; -.
DR UCSC; uc008vqb.2; mouse.
DR CTD; 126755; -.
DR MGI; MGI:2442845; Lrrc38.
DR VEuPathDB; HostDB:ENSMUSG00000028584; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000162571; -.
DR HOGENOM; CLU_000288_18_10_1; -.
DR InParanoid; A2VDH3; -.
DR OMA; CAPSKDD; -.
DR OrthoDB; 826997at2759; -.
DR PhylomeDB; A2VDH3; -.
DR TreeFam; TF334689; -.
DR BioGRID-ORCS; 242735; 1 hit in 71 CRISPR screens.
DR PRO; PR:A2VDH3; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; A2VDH3; protein.
DR Bgee; ENSMUSG00000028584; Expressed in quadriceps femoris and 22 other tissues.
DR Genevisible; A2VDH3; MM.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; ISO:MGI.
DR GO; GO:0099104; F:potassium channel activator activity; ISO:MGI.
DR GO; GO:0044325; F:transmembrane transporter binding; ISO:MGI.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR GO; GO:1903818; P:positive regulation of voltage-gated potassium channel activity; ISO:MGI.
DR GO; GO:0071805; P:potassium ion transmembrane transport; ISO:MGI.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Ion channel; Ion transport;
KW Leucine-rich repeat; Membrane; Reference proteome; Repeat; Signal;
KW Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..298
FT /note="Leucine-rich repeat-containing protein 38"
FT /id="PRO_0000312419"
FT TOPO_DOM 32..251
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..298
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 32..60
FT /note="LRRNT"
FT REPEAT 61..82
FT /note="LRR 1"
FT REPEAT 85..106
FT /note="LRR 2"
FT REPEAT 109..130
FT /note="LRR 3"
FT REPEAT 133..154
FT /note="LRR 4"
FT REPEAT 157..177
FT /note="LRR 5"
FT DOMAIN 190..245
FT /note="LRRCT"
FT CARBOHYD 119
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 32..38
FT /evidence="ECO:0000255"
FT DISULFID 36..46
FT /evidence="ECO:0000255"
FT DISULFID 194..221
FT /evidence="ECO:0000255"
FT DISULFID 196..243
FT /evidence="ECO:0000255"
SQ SEQUENCE 298 AA; 32343 MW; 7B278DB70683569E CRC64;
MSLCVAPRHP TGAAAALGLG SLLVLLGPGR ACPAGCACTD PHTVDCRDRG LPSVPDPFPL
DVRKLLVAGN RIQQIPEDFF IFHGDLVYLD FRNNSLRSLE EGTFSGSGKL AFLDLSYNNL
TQLGAGAFRS AGRLVKLSLA NNHLAGVHEA AFESLESLQV LELNDNNLRS LNVAALDALP
ALRTVRLDGN PWLCDCDFAH LFSWIQENTS KLPKGLDAIQ CSLPMEDRRV ALRELSEASF
SECKFSLSLT DLFIIIFSGV AVSIAAIISS FFLATVVQCF QRCAPNKDTE DEDDDEDD
