ID   LRC39_BOVIN             Reviewed;         334 AA.
AC   Q3ZC49;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Leucine-rich repeat-containing protein 39 {ECO:0000305};
DE   AltName: Full=Myosin-interacting M-band-associated stress-responsive protein {ECO:0000250|UniProtKB:Q96DD0};
DE            Short=Myomasp {ECO:0000250|UniProtKB:Q96DD0};
GN   Name=LRRC39 {ECO:0000250|UniProtKB:Q96DD0};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Rumen;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the sarcomeric M-band which plays a role in
CC       myocyte response to biomechanical stress. May regulate expression of
CC       other M-band proteins via an SRF-dependent pathway. Important for
CC       normal contractile function in heart. {ECO:0000250|UniProtKB:D3ZXS4}.
CC   -!- SUBUNIT: Interacts with MYH7 (via C-terminus).
CC       {ECO:0000250|UniProtKB:Q96DD0}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, M line
CC       {ECO:0000250|UniProtKB:D3ZXS4}.
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DR   EMBL; BC102917; AAI02918.1; -; mRNA.
DR   RefSeq; NP_001069893.1; NM_001076425.1.
DR   AlphaFoldDB; Q3ZC49; -.
DR   SMR; Q3ZC49; -.
DR   STRING; 9913.ENSBTAP00000048641; -.
DR   PaxDb; Q3ZC49; -.
DR   PRIDE; Q3ZC49; -.
DR   Ensembl; ENSBTAT00000053822; ENSBTAP00000048641; ENSBTAG00000015786.
DR   GeneID; 616488; -.
DR   KEGG; bta:616488; -.
DR   CTD; 127495; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015786; -.
DR   VGNC; VGNC:55250; LRRC39.
DR   eggNOG; KOG0619; Eukaryota.
DR   GeneTree; ENSGT00940000158998; -.
DR   HOGENOM; CLU_000288_18_8_1; -.
DR   InParanoid; Q3ZC49; -.
DR   OMA; PPLMEDM; -.
DR   OrthoDB; 1085197at2759; -.
DR   TreeFam; TF333627; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000015786; Expressed in cardiac ventricle and 39 other tissues.
DR   ExpressionAtlas; Q3ZC49; baseline.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0031430; C:M band; IEA:UniProtKB-SubCell.
DR   GO; GO:0004722; F:protein serine/threonine phosphatase activity; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13855; LRR_8; 3.
DR   SMART; SM00369; LRR_TYP; 6.
DR   PROSITE; PS51450; LRR; 7.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Leucine-rich repeat; Muscle protein;
KW   Reference proteome; Repeat.
FT   CHAIN           1..334
FT                   /note="Leucine-rich repeat-containing protein 39"
FT                   /id="PRO_0000232579"
FT   REPEAT          84..105
FT                   /note="LRR 1"
FT   REPEAT          107..128
FT                   /note="LRR 2"
FT   REPEAT          130..151
FT                   /note="LRR 3"
FT   REPEAT          153..176
FT                   /note="LRR 4"
FT   REPEAT          177..198
FT                   /note="LRR 5"
FT   REPEAT          200..221
FT                   /note="LRR 6"
FT   REPEAT          223..244
FT                   /note="LRR 7"
FT   REPEAT          246..267
FT                   /note="LRR 8"
FT   REPEAT          269..290
FT                   /note="LRR 9"
FT   COILED          10..47
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   334 AA;  38787 MW;  66BA286F1415AD13 CRC64;
     MSENVVSTGA VNAVKEVWEK RIKKLNEDLK REKEFQQKLV RIWEERVCLT KLREKVTKED
     GRVILKIEKE EWKTLPSSLL KLNQLQEWQL HRIGLLKIPE FIGRFQNLIV LDLSRNTITE
     IPRGIGLLTR LQELILSYNR IKTVPMELSY CASLEKLELA VNRDISDLPQ ELSNLLKLTH
     LDLSMNLFTT IPPAVLNMPA LEWLDMGSNR LEQLPDTIER MQNLHTLWLQ RNEITCLPET
     ISSMKNLSTL VLSNNKLQDI PVCMEKMTNL RFVNFRDNPL KLEVTLPPSE NIEEEEEREL
     FGLQFMHTYI QESRRAGNQV NCSTTSPNSI DADG