LRC39_MOUSE
ID LRC39_MOUSE Reviewed; 337 AA.
AC Q8BGI7;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Leucine-rich repeat-containing protein 39 {ECO:0000305};
DE AltName: Full=Myosin-interacting M-band-associated stress-responsive protein {ECO:0000250|UniProtKB:D3ZXS4};
DE Short=Myomasp {ECO:0000250|UniProtKB:D3ZXS4};
GN Name=Lrrc39 {ECO:0000312|MGI:MGI:1924557};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, Embryonic heart, and Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=20847312; DOI=10.1161/circresaha.110.222372;
RA Will R.D., Eden M., Just S., Hansen A., Eder A., Frank D., Kuhn C.,
RA Seeger T.S., Oehl U., Wiemann S., Korn B., Koegl M., Rottbauer W.,
RA Eschenhagen T., Katus H.A., Frey N.;
RT "Myomasp/LRRC39, a heart- and muscle-specific protein, is a novel component
RT of the sarcomeric M-band and is involved in stretch sensing.";
RL Circ. Res. 107:1253-1264(2010).
CC -!- FUNCTION: Component of the sarcomeric M-band which plays a role in
CC myocyte response to biomechanical stress. May regulate expression of
CC other M-band proteins via an SRF-dependent pathway. Important for
CC normal contractile function in heart. {ECO:0000250|UniProtKB:D3ZXS4}.
CC -!- SUBUNIT: Interacts with MYH7 (via C-terminus).
CC {ECO:0000250|UniProtKB:Q96DD0}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, M line
CC {ECO:0000250|UniProtKB:D3ZXS4}.
CC -!- TISSUE SPECIFICITY: Expressed in heart and skeletal muscle.
CC {ECO:0000269|PubMed:20847312}.
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DR EMBL; AK039277; BAC30303.1; -; mRNA.
DR EMBL; AK052159; BAC34863.1; -; mRNA.
DR EMBL; AK079125; BAC37551.1; -; mRNA.
DR CCDS; CCDS17788.1; -.
DR RefSeq; NP_780622.1; NM_175413.3.
DR AlphaFoldDB; Q8BGI7; -.
DR SMR; Q8BGI7; -.
DR STRING; 10090.ENSMUSP00000029573; -.
DR iPTMnet; Q8BGI7; -.
DR PhosphoSitePlus; Q8BGI7; -.
DR MaxQB; Q8BGI7; -.
DR PaxDb; Q8BGI7; -.
DR PRIDE; Q8BGI7; -.
DR ProteomicsDB; 252506; -.
DR Antibodypedia; 33693; 188 antibodies from 20 providers.
DR DNASU; 109245; -.
DR Ensembl; ENSMUST00000029573; ENSMUSP00000029573; ENSMUSG00000027961.
DR GeneID; 109245; -.
DR KEGG; mmu:109245; -.
DR UCSC; uc008rci.2; mouse.
DR CTD; 127495; -.
DR MGI; MGI:1924557; Lrrc39.
DR VEuPathDB; HostDB:ENSMUSG00000027961; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000158998; -.
DR HOGENOM; CLU_000288_18_8_1; -.
DR InParanoid; Q8BGI7; -.
DR OMA; PPLMEDM; -.
DR OrthoDB; 1085197at2759; -.
DR PhylomeDB; Q8BGI7; -.
DR TreeFam; TF333627; -.
DR BioGRID-ORCS; 109245; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Lrrc39; mouse.
DR PRO; PR:Q8BGI7; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q8BGI7; protein.
DR Bgee; ENSMUSG00000027961; Expressed in soleus muscle and 86 other tissues.
DR ExpressionAtlas; Q8BGI7; baseline and differential.
DR Genevisible; Q8BGI7; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0031430; C:M band; IEA:UniProtKB-SubCell.
DR GO; GO:0004722; F:protein serine/threonine phosphatase activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00369; LRR_TYP; 6.
DR PROSITE; PS51450; LRR; 7.
PE 1: Evidence at protein level;
KW Cytoplasm; Leucine-rich repeat; Muscle protein; Reference proteome; Repeat.
FT CHAIN 1..337
FT /note="Leucine-rich repeat-containing protein 39"
FT /id="PRO_0000232581"
FT REPEAT 84..105
FT /note="LRR 1"
FT REPEAT 107..128
FT /note="LRR 2"
FT REPEAT 130..152
FT /note="LRR 3"
FT REPEAT 153..176
FT /note="LRR 4"
FT REPEAT 177..198
FT /note="LRR 5"
FT REPEAT 200..221
FT /note="LRR 6"
FT REPEAT 223..244
FT /note="LRR 7"
FT REPEAT 246..267
FT /note="LRR 8"
FT REPEAT 269..290
FT /note="LRR 9"
SQ SEQUENCE 337 AA; 39061 MW; 9565978A7716BCD8 CRC64;
MTESAVCTGA VSAVKEVWEE RIKKHHEDVK REKEFQHKLV RIWEDRVSLT KLKEKVTRED
GRVILRIEKE EWKTLPSSLL KLNQLQEWQL HRTGLLKIPE FIGRFQHLIV LDLSRNTISE
IPRGIGLLTR LQELILSYNK IKTVPKELSN CTSLEKLELA VNRDISDLPP ELSKLLKLTH
LDLSMNQFTT IPHAVLDMPA LEWLDMGSNS LQQLPDSLDR MRSLHTLWLQ RNEITCLPET
IKNMKNLGTL VLSNNKLQDI PGCMEEMTNL RFVNFRDNPL RLEVTLPPSD NTDGEEEQEL
FGLQFMHAYI QESRRTEDQV NCLTQMPSSI HSDGESN
