LRC39_RAT
ID LRC39_RAT Reviewed; 334 AA.
AC D3ZXS4;
DT 27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Leucine-rich repeat-containing protein 39 {ECO:0000305};
DE AltName: Full=Myosin-interacting M-band-associated stress-responsive protein {ECO:0000303|PubMed:20847312};
DE Short=Myomasp {ECO:0000303|PubMed:20847312};
GN Name=Lrrc39 {ECO:0000312|RGD:1585106};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=20847312; DOI=10.1161/circresaha.110.222372;
RA Will R.D., Eden M., Just S., Hansen A., Eder A., Frank D., Kuhn C.,
RA Seeger T.S., Oehl U., Wiemann S., Korn B., Koegl M., Rottbauer W.,
RA Eschenhagen T., Katus H.A., Frey N.;
RT "Myomasp/LRRC39, a heart- and muscle-specific protein, is a novel component
RT of the sarcomeric M-band and is involved in stretch sensing.";
RL Circ. Res. 107:1253-1264(2010).
CC -!- FUNCTION: Component of the sarcomeric M-band which plays a role in
CC myocyte response to biomechanical stress. May regulate expression of
CC other M-band proteins via an SRF-dependent pathway. Important for
CC normal contractile function in heart. {ECO:0000269|PubMed:20847312}.
CC -!- SUBUNIT: Interacts with MYH7 (via C-terminus).
CC {ECO:0000250|UniProtKB:Q96DD0}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, M line
CC {ECO:0000269|PubMed:20847312}.
CC -!- TISSUE SPECIFICITY: Expressed in heart and skeletal muscle (at protein
CC level). Also detected in kidney (at protein level). Not detected in
CC other tissues tested (at protein level). {ECO:0000269|PubMed:20847312}.
CC -!- INDUCTION: In cardiomyocytes, down-regulated in response to
CC biomechanical stress. {ECO:0000269|PubMed:20847312}.
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DR EMBL; AC119448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH473952; EDL82035.1; -; Genomic_DNA.
DR RefSeq; NP_001103107.1; NM_001109637.1.
DR RefSeq; XP_006233293.1; XM_006233231.3.
DR AlphaFoldDB; D3ZXS4; -.
DR SMR; D3ZXS4; -.
DR STRING; 10116.ENSRNOP00000020297; -.
DR PaxDb; D3ZXS4; -.
DR Ensembl; ENSRNOT00000020297; ENSRNOP00000020297; ENSRNOG00000015117.
DR GeneID; 691307; -.
DR KEGG; rno:691307; -.
DR UCSC; RGD:1585106; rat.
DR CTD; 127495; -.
DR RGD; 1585106; Lrrc39.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000158998; -.
DR HOGENOM; CLU_000288_18_8_1; -.
DR InParanoid; D3ZXS4; -.
DR OMA; PPLMEDM; -.
DR OrthoDB; 1085197at2759; -.
DR PhylomeDB; D3ZXS4; -.
DR TreeFam; TF333627; -.
DR PRO; PR:D3ZXS4; -.
DR Proteomes; UP000002494; Chromosome 2.
DR Proteomes; UP000234681; Chromosome 2.
DR Bgee; ENSRNOG00000015117; Expressed in heart and 16 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0031430; C:M band; IEA:UniProtKB-SubCell.
DR GO; GO:0004722; F:protein serine/threonine phosphatase activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00369; LRR_TYP; 6.
DR PROSITE; PS51450; LRR; 7.
PE 1: Evidence at protein level;
KW Cytoplasm; Leucine-rich repeat; Muscle protein; Reference proteome; Repeat.
FT CHAIN 1..334
FT /note="Leucine-rich repeat-containing protein 39"
FT /id="PRO_0000441698"
FT REPEAT 59..82
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 83..105
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 106..128
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 129..151
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 153..175
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 176..198
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 199..221
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 223..244
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 245..269
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REPEAT 272..295
FT /note="LRR 10"
FT /evidence="ECO:0000255"
SQ SEQUENCE 334 AA; 38716 MW; E71649D728DC953C CRC64;
MTESVVCTGA VSTVKEVWEE RIKKHHEDVK REKEFQQKLV RIWEDRVSLT KLKEKVTRED
GRIILRIEKE EWKTLPSSLL KLNQLQEWQL HRTGLLKIPE FIGRFQHLIV LDLSRNTISE
IPRGIGLLTR LQELILSYNK IKTVPKELSN CASLEKLELA VNRDISDLPT ELSKLLKLTH
LDLSMNQFTT IPLAVLDMPA LEWLDMGSNS LQQLPDTLDR MQSLHTLWLQ RNEITCLPET
IRNMKNLGTL VLSNNKLQDI PGCMEEMTSL RFVNFRDNPL RLEVTLPPSD DVDGEEEQEL
FGLQFMHAYI QESRRTEDQV NCLTHTPSST RSDG
