ID   LRC3B_DANRE             Reviewed;         258 AA.
AC   A3KNN3;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Leucine-rich repeat-containing protein 3B;
DE   Flags: Precursor;
GN   Name=lrrc3b; ORFNames=zgc:162270;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the LRRC3 family. {ECO:0000305}.
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DR   EMBL; BC133927; AAI33928.1; -; mRNA.
DR   RefSeq; NP_001082985.1; NM_001089516.1.
DR   RefSeq; XP_005173781.1; XM_005173724.3.
DR   AlphaFoldDB; A3KNN3; -.
DR   SMR; A3KNN3; -.
DR   STRING; 7955.ENSDARP00000086615; -.
DR   PaxDb; A3KNN3; -.
DR   ABCD; A3KNN3; 2 sequenced antibodies.
DR   Ensembl; ENSDART00000092183; ENSDARP00000086615; ENSDARG00000063215.
DR   GeneID; 100037364; -.
DR   KEGG; dre:100037364; -.
DR   CTD; 116135; -.
DR   ZFIN; ZDB-GENE-070410-55; lrrc3b.
DR   eggNOG; KOG4237; Eukaryota.
DR   GeneTree; ENSGT00940000157780; -.
DR   HOGENOM; CLU_064640_0_0_1; -.
DR   InParanoid; A3KNN3; -.
DR   OMA; ISGMAHN; -.
DR   OrthoDB; 1050061at2759; -.
DR   PhylomeDB; A3KNN3; -.
DR   TreeFam; TF327070; -.
DR   PRO; PR:A3KNN3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 19.
DR   Bgee; ENSDARG00000063215; Expressed in olfactory system and 12 other tissues.
DR   GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   Pfam; PF00560; LRR_1; 1.
DR   Pfam; PF13855; LRR_8; 1.
DR   SMART; SM00369; LRR_TYP; 3.
DR   SMART; SM00013; LRRNT; 1.
DR   PROSITE; PS51450; LRR; 2.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Leucine-rich repeat; Membrane; Reference proteome; Repeat;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000255"
FT   CHAIN           34..258
FT                   /note="Leucine-rich repeat-containing protein 3B"
FT                   /id="PRO_0000345966"
FT   TRANSMEM        204..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          34..68
FT                   /note="LRRNT"
FT   REPEAT          69..90
FT                   /note="LRR 1"
FT   REPEAT          93..114
FT                   /note="LRR 2"
FT   REPEAT          118..139
FT                   /note="LRR 3"
FT   DOMAIN          149..196
FT                   /note="LRRCT"
FT   CARBOHYD        51
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        98
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   258 AA;  29100 MW;  673251C44366116E CRC64;
     MTPLDLWLSR SIPMCLLLQS LVLMVLCFPS ASTCPKGCTC QRSESPPHGL NVTCSLSRLK
     EIPPDVPPDT QLLQLDRNHI SLVPDRIFHG LRMLRRLNLS HNAVETLGEG AFIGLEGSLE
     VLDLSYNRIT SVHKDAFARL KARVVVDNNP WHCDCALQQA LGGMAHNHER VLCRSSELRD
     QEGQPFMAVD ADLCNLAKRT TDYAMLVTMF GWFAMVISYV VYYVRQNQED ARRHLEYLKS
     LPSKPKKPDE PEDISTVV