ID   LRC3B_HUMAN             Reviewed;         259 AA.
AC   Q96PB8; Q5M8T0;
DT   19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 165.
DE   RecName: Full=Leucine-rich repeat-containing protein 3B;
DE   AltName: Full=Leucine-rich repeat protein 15;
DE   Flags: Precursor;
GN   Name=LRRC3B; Synonyms=LRP15; ORFNames=UNQ195/PRO221;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Yu L., Xu Z., Han W., Li X., Lu X., Lou F., Wang Q., Zhao Y., Jing Y.,
RA   Plass C., Strout M.P., Yu F., Krahe R., Caligiuri M.A.;
RL   Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q96PB8; P11049: CD37; NbExp=3; IntAct=EBI-17775622, EBI-6139068;
CC       Q96PB8; P54849: EMP1; NbExp=3; IntAct=EBI-17775622, EBI-4319440;
CC       Q96PB8; Q5J8X5: MS4A13; NbExp=3; IntAct=EBI-17775622, EBI-12070086;
CC       Q96PB8; Q6QAJ8: TMEM220; NbExp=3; IntAct=EBI-17775622, EBI-17963211;
CC       Q96PB8; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-17775622, EBI-2852148;
CC       Q96PB8; Q96EC8: YIPF6; NbExp=3; IntAct=EBI-17775622, EBI-751210;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the LRRC3 family. {ECO:0000305}.
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DR   EMBL; AF396933; AAK84157.1; -; mRNA.
DR   EMBL; AY358282; AAQ88649.1; -; mRNA.
DR   EMBL; BC040656; AAH40656.1; -; mRNA.
DR   EMBL; BC067784; AAH67784.1; -; mRNA.
DR   EMBL; BC087849; AAH87849.1; -; mRNA.
DR   CCDS; CCDS2644.1; -.
DR   RefSeq; NP_001304737.1; NM_001317808.1.
DR   RefSeq; NP_001304738.1; NM_001317809.1.
DR   RefSeq; NP_001304739.1; NM_001317810.1.
DR   RefSeq; NP_001304740.1; NM_001317811.1.
DR   RefSeq; NP_443185.1; NM_052953.3.
DR   RefSeq; XP_005264906.1; XM_005264849.3.
DR   RefSeq; XP_005264907.1; XM_005264850.4.
DR   RefSeq; XP_011531634.1; XM_011533332.2.
DR   RefSeq; XP_016861164.1; XM_017005675.1.
DR   PDB; 5EMA; X-ray; 1.32 A; B=252-259.
DR   PDBsum; 5EMA; -.
DR   AlphaFoldDB; Q96PB8; -.
DR   SMR; Q96PB8; -.
DR   BioGRID; 125477; 13.
DR   IntAct; Q96PB8; 6.
DR   STRING; 9606.ENSP00000379880; -.
DR   GlyGen; Q96PB8; 2 sites.
DR   iPTMnet; Q96PB8; -.
DR   PhosphoSitePlus; Q96PB8; -.
DR   BioMuta; LRRC3B; -.
DR   DMDM; 24211927; -.
DR   EPD; Q96PB8; -.
DR   MassIVE; Q96PB8; -.
DR   PaxDb; Q96PB8; -.
DR   PeptideAtlas; Q96PB8; -.
DR   PRIDE; Q96PB8; -.
DR   Antibodypedia; 2670; 108 antibodies from 21 providers.
DR   DNASU; 116135; -.
DR   Ensembl; ENST00000396641.6; ENSP00000379880.2; ENSG00000179796.12.
DR   Ensembl; ENST00000417744.5; ENSP00000406370.1; ENSG00000179796.12.
DR   Ensembl; ENST00000456208.2; ENSP00000394940.2; ENSG00000179796.12.
DR   Ensembl; ENST00000648296.1; ENSP00000497471.1; ENSG00000179796.12.
DR   GeneID; 116135; -.
DR   KEGG; hsa:116135; -.
DR   MANE-Select; ENST00000396641.7; ENSP00000379880.2; NM_052953.4; NP_443185.1.
DR   UCSC; uc003cdp.4; human.
DR   CTD; 116135; -.
DR   DisGeNET; 116135; -.
DR   GeneCards; LRRC3B; -.
DR   HGNC; HGNC:28105; LRRC3B.
DR   HPA; ENSG00000179796; Tissue enhanced (brain, choroid plexus, skeletal muscle).
DR   MIM; 618996; gene.
DR   neXtProt; NX_Q96PB8; -.
DR   OpenTargets; ENSG00000179796; -.
DR   PharmGKB; PA134962068; -.
DR   VEuPathDB; HostDB:ENSG00000179796; -.
DR   eggNOG; KOG4237; Eukaryota.
DR   GeneTree; ENSGT00940000157780; -.
DR   HOGENOM; CLU_064640_0_0_1; -.
DR   InParanoid; Q96PB8; -.
DR   OMA; ISGMAHN; -.
DR   OrthoDB; 1050061at2759; -.
DR   PhylomeDB; Q96PB8; -.
DR   TreeFam; TF327070; -.
DR   PathwayCommons; Q96PB8; -.
DR   SignaLink; Q96PB8; -.
DR   BioGRID-ORCS; 116135; 9 hits in 1063 CRISPR screens.
DR   ChiTaRS; LRRC3B; human.
DR   GenomeRNAi; 116135; -.
DR   Pharos; Q96PB8; Tbio.
DR   PRO; PR:Q96PB8; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; Q96PB8; protein.
DR   Bgee; ENSG00000179796; Expressed in ventricular zone and 128 other tissues.
DR   ExpressionAtlas; Q96PB8; baseline and differential.
DR   Genevisible; Q96PB8; HS.
DR   GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   Pfam; PF00560; LRR_1; 1.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF01462; LRRNT; 1.
DR   SMART; SM00369; LRR_TYP; 3.
DR   SMART; SM00013; LRRNT; 1.
DR   PROSITE; PS51450; LRR; 3.
PE   1: Evidence at protein level;
KW   3D-structure; Glycoprotein; Leucine-rich repeat; Membrane;
KW   Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000255"
FT   CHAIN           34..259
FT                   /note="Leucine-rich repeat-containing protein 3B"
FT                   /id="PRO_0000021616"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          34..64
FT                   /note="LRRNT"
FT   REPEAT          65..86
FT                   /note="LRR 1"
FT   REPEAT          89..110
FT                   /note="LRR 2"
FT   REPEAT          114..135
FT                   /note="LRR 3"
FT   DOMAIN          145..197
FT                   /note="LRRCT"
FT   CARBOHYD        47
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        94
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   STRAND          255..258
FT                   /evidence="ECO:0007829|PDB:5EMA"
SQ   SEQUENCE   259 AA;  29275 MW;  21BEF20C680A9A04 CRC64;
     MNLVDLWLTR SLSMCLLLQS FVLMILCFHS ASMCPKGCLC SSSGGLNVTC SNANLKEIPR
     DLPPETVLLY LDSNQITSIP NEIFKDLHQL RVLNLSKNGI EFIDEHAFKG VAETLQTLDL
     SDNRIQSVHK NAFNNLKARA RIANNPWHCD CTLQQVLRSM ASNHETAHNV ICKTSVLDEH
     AGRPFLNAAN DADLCNLPKK TTDYAMLVTM FGWFTMVISY VVYYVRQNQE DARRHLEYLK
     SLPSRQKKAD EPDDISTVV