ID   LRC3B_MOUSE             Reviewed;         259 AA.
AC   Q8VCH9;
DT   19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=Leucine-rich repeat-containing protein 3B;
DE   AltName: Full=Leucine-rich repeat protein 15;
DE   Flags: Precursor;
GN   Name=Lrrc3b; Synonyms=Lrp15;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Retina;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the LRRC3 family. {ECO:0000305}.
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DR   EMBL; BC019794; AAH19794.1; -; mRNA.
DR   CCDS; CCDS26829.1; -.
DR   RefSeq; NP_666164.1; NM_146052.4.
DR   RefSeq; XP_006518068.1; XM_006518005.2.
DR   RefSeq; XP_006518069.1; XM_006518006.1.
DR   AlphaFoldDB; Q8VCH9; -.
DR   SMR; Q8VCH9; -.
DR   STRING; 10090.ENSMUSP00000059463; -.
DR   GlyGen; Q8VCH9; 2 sites.
DR   iPTMnet; Q8VCH9; -.
DR   PhosphoSitePlus; Q8VCH9; -.
DR   PaxDb; Q8VCH9; -.
DR   PRIDE; Q8VCH9; -.
DR   ProteomicsDB; 287268; -.
DR   Antibodypedia; 2670; 108 antibodies from 21 providers.
DR   Ensembl; ENSMUST00000055211; ENSMUSP00000059463; ENSMUSG00000045201.
DR   Ensembl; ENSMUST00000163937; ENSMUSP00000128624; ENSMUSG00000045201.
DR   Ensembl; ENSMUST00000223700; ENSMUSP00000153616; ENSMUSG00000045201.
DR   GeneID; 218763; -.
DR   KEGG; mmu:218763; -.
DR   UCSC; uc007sgt.3; mouse.
DR   CTD; 116135; -.
DR   MGI; MGI:2384996; Lrrc3b.
DR   VEuPathDB; HostDB:ENSMUSG00000045201; -.
DR   eggNOG; KOG4237; Eukaryota.
DR   GeneTree; ENSGT00940000157780; -.
DR   HOGENOM; CLU_064640_0_0_1; -.
DR   InParanoid; Q8VCH9; -.
DR   OMA; ISGMAHN; -.
DR   OrthoDB; 1050061at2759; -.
DR   PhylomeDB; Q8VCH9; -.
DR   TreeFam; TF327070; -.
DR   BioGRID-ORCS; 218763; 1 hit in 72 CRISPR screens.
DR   ChiTaRS; Lrrc3b; mouse.
DR   PRO; PR:Q8VCH9; -.
DR   Proteomes; UP000000589; Chromosome 14.
DR   RNAct; Q8VCH9; protein.
DR   Bgee; ENSMUSG00000045201; Expressed in habenula and 153 other tissues.
DR   ExpressionAtlas; Q8VCH9; baseline and differential.
DR   Genevisible; Q8VCH9; MM.
DR   GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   Pfam; PF00560; LRR_1; 1.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF01462; LRRNT; 1.
DR   SMART; SM00369; LRR_TYP; 3.
DR   SMART; SM00013; LRRNT; 1.
DR   PROSITE; PS51450; LRR; 3.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Leucine-rich repeat; Membrane; Reference proteome; Repeat;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000255"
FT   CHAIN           34..259
FT                   /note="Leucine-rich repeat-containing protein 3B"
FT                   /id="PRO_0000021617"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          34..64
FT                   /note="LRRNT"
FT   REPEAT          65..86
FT                   /note="LRR 1"
FT   REPEAT          89..110
FT                   /note="LRR 2"
FT   REPEAT          114..135
FT                   /note="LRR 3"
FT   DOMAIN          145..197
FT                   /note="LRRCT"
FT   CARBOHYD        47
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        94
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   259 AA;  29261 MW;  21BEF3D7680A9914 CRC64;
     MNLVDLWLSR SLSMCLLLQS FVLMILCFHS ASMCPKGCLC SSSGGLNVTC SNANLKEIPR
     DLPPETVLLY LDSNQITSIP NEIFKDLHQL RVLNLSKNGI EFIDEHAFKG VAETLQTLDL
     SDNRIQSVHK NAFNNLKARA RIANNPWHCD CTLQQVLRSM ASNHETAHNV ICKTSVLDEH
     AGRPFLNAAN DADLCNLPKK TTDYAMLVTM FGWFTMVISY VVYYVRQNQE DARRHLEYLK
     SLPSRQKKAD EPDDISTVV