ID   LRC40_DANRE             Reviewed;         601 AA.
AC   Q7SXW3; Q6TLH1;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Leucine-rich repeat-containing protein 40;
GN   Name=lrrc40; ORFNames=zgc:63729;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney marrow;
RX   PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA   Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA   Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA   Look A.T., Chen Z.;
RT   "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AY394934; AAQ94561.1; -; mRNA.
DR   EMBL; BC055223; AAH55223.1; -; mRNA.
DR   RefSeq; NP_956156.2; NM_199862.2.
DR   AlphaFoldDB; Q7SXW3; -.
DR   SMR; Q7SXW3; -.
DR   STRING; 7955.ENSDARP00000016699; -.
DR   PaxDb; Q7SXW3; -.
DR   GeneID; 334130; -.
DR   KEGG; dre:334130; -.
DR   CTD; 55631; -.
DR   ZFIN; ZDB-GENE-030131-6062; lrrc40.
DR   eggNOG; KOG0472; Eukaryota.
DR   InParanoid; Q7SXW3; -.
DR   OrthoDB; 826997at2759; -.
DR   PhylomeDB; Q7SXW3; -.
DR   PRO; PR:Q7SXW3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0004722; F:protein serine/threonine phosphatase activity; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 4.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13855; LRR_8; 5.
DR   SMART; SM00369; LRR_TYP; 14.
DR   PROSITE; PS51450; LRR; 17.
PE   2: Evidence at transcript level;
KW   Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..601
FT                   /note="Leucine-rich repeat-containing protein 40"
FT                   /id="PRO_0000226262"
FT   REPEAT          33..56
FT                   /note="LRR 1"
FT   REPEAT          79..101
FT                   /note="LRR 2"
FT   REPEAT          102..124
FT                   /note="LRR 3"
FT   REPEAT          125..148
FT                   /note="LRR 4"
FT   REPEAT          150..170
FT                   /note="LRR 5"
FT   REPEAT          171..193
FT                   /note="LRR 6"
FT   REPEAT          194..217
FT                   /note="LRR 7"
FT   REPEAT          219..239
FT                   /note="LRR 8"
FT   REPEAT          240..264
FT                   /note="LRR 9"
FT   REPEAT          266..285
FT                   /note="LRR 10"
FT   REPEAT          286..308
FT                   /note="LRR 11"
FT   REPEAT          309..334
FT                   /note="LRR 12"
FT   REPEAT          336..355
FT                   /note="LRR 13"
FT   REPEAT          397..420
FT                   /note="LRR 14"
FT   REPEAT          423..446
FT                   /note="LRR 15"
FT   REPEAT          447..469
FT                   /note="LRR 16"
FT   REPEAT          470..492
FT                   /note="LRR 17"
FT   REPEAT          493..516
FT                   /note="LRR 18"
FT   REPEAT          518..539
FT                   /note="LRR 19"
FT   REPEAT          540..563
FT                   /note="LRR 20"
FT   REPEAT          565..586
FT                   /note="LRR 21"
FT   CONFLICT        13
FT                   /note="G -> R (in Ref. 1; AAQ94561)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        176
FT                   /note="E -> D (in Ref. 1; AAQ94561)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        387
FT                   /note="P -> Q (in Ref. 1; AAQ94561)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        394
FT                   /note="V -> I (in Ref. 1; AAQ94561)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        412
FT                   /note="T -> S (in Ref. 1; AAQ94561)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        418
FT                   /note="F -> L (in Ref. 1; AAQ94561)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        449
FT                   /note="S -> T (in Ref. 1; AAQ94561)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   601 AA;  67316 MW;  56FE19A80C211267 CRC64;
     MSRFKRGAHV DSGAGFRQEK EDCPVPYGLL KAARKSGQLN LSGRGLTEVP ASVWRLNLDT
     PQEAKQNVSF GAEDRWWEQT DLTKLLLSSN KLQSIPDDVK LLPALVVLDI HDNQLSSLPD
     SIGDLEQLQK LILSHNKLTE LPSGVWRLTN LRCLHLQQNL IEQIPRDLGQ LVNLDELDLS
     NNHLIDIPES LANLQNLVKL DLSCNKLKSL PPAISQMKNL RMLDCSRNQM ESIPPVLAQM
     ESLEQLYLRH NKLRYLPELP CCKTLKELHC GNNQIEVLEA EHLKHLNALS LLELRDNKVK
     SLPEEITLLQ GLERLDLTNN DISSLPCGLG TLPKLKSLSL EGNPLRAIRR DLLTKGTGEL
     LKYLRSRVQE PPNGGLKEEP KTAMTFPSQA KINVHAIKTL KTLDYSEKQD ATIPDDVFDA
     VDGNPVANVN FSKNQLTAVP HRIVDLKDSL ADINLGFNKL TTIPADFCHL KQLMHIDLRN
     NLLISLPMEL EGLIKLRSVI LSFNRFKSFP EVLYRIPSLE TILISSNQVG GIDAVQMKTL
     SRLSTLDLSN NDIMQVPPEL GNCTSLRALM LDGNPFRNPR AAILIKGTDA VLEYLRSRIP
     T