LRC40_MOUSE
ID LRC40_MOUSE Reviewed; 602 AA.
AC Q9CRC8; Q78WQ9; Q8BS83;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 2.
DT 25-MAY-2022, entry version 144.
DE RecName: Full=Leucine-rich repeat-containing protein 40;
GN Name=Lrrc40;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Kidney, Liver, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
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DR EMBL; AK011726; BAB27802.2; -; mRNA.
DR EMBL; AK017814; BAB30951.2; -; mRNA.
DR EMBL; AK034978; BAC28900.1; -; mRNA.
DR EMBL; AK163288; BAE37277.1; -; mRNA.
DR CCDS; CCDS17935.1; -.
DR RefSeq; NP_001276453.1; NM_001289524.1.
DR RefSeq; NP_077156.2; NM_024194.6.
DR AlphaFoldDB; Q9CRC8; -.
DR SMR; Q9CRC8; -.
DR BioGRID; 211974; 8.
DR STRING; 10090.ENSMUSP00000071956; -.
DR iPTMnet; Q9CRC8; -.
DR PhosphoSitePlus; Q9CRC8; -.
DR EPD; Q9CRC8; -.
DR MaxQB; Q9CRC8; -.
DR PaxDb; Q9CRC8; -.
DR PeptideAtlas; Q9CRC8; -.
DR PRIDE; Q9CRC8; -.
DR ProteomicsDB; 252669; -.
DR DNASU; 67144; -.
DR GeneID; 67144; -.
DR KEGG; mmu:67144; -.
DR UCSC; uc008rvu.2; mouse.
DR CTD; 55631; -.
DR MGI; MGI:1914394; Lrrc40.
DR eggNOG; KOG0472; Eukaryota.
DR InParanoid; Q9CRC8; -.
DR OrthoDB; 826997at2759; -.
DR PhylomeDB; Q9CRC8; -.
DR TreeFam; TF354310; -.
DR BioGRID-ORCS; 67144; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Lrrc40; mouse.
DR PRO; PR:Q9CRC8; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q9CRC8; protein.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0004722; F:protein serine/threonine phosphatase activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 5.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 4.
DR SMART; SM00369; LRR_TYP; 13.
DR PROSITE; PS51450; LRR; 16.
PE 1: Evidence at protein level;
KW Leucine-rich repeat; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..602
FT /note="Leucine-rich repeat-containing protein 40"
FT /id="PRO_0000226259"
FT REPEAT 35..58
FT /note="LRR 1"
FT REPEAT 81..103
FT /note="LRR 2"
FT REPEAT 104..126
FT /note="LRR 3"
FT REPEAT 127..149
FT /note="LRR 4"
FT REPEAT 150..172
FT /note="LRR 5"
FT REPEAT 174..195
FT /note="LRR 6"
FT REPEAT 196..219
FT /note="LRR 7"
FT REPEAT 221..241
FT /note="LRR 8"
FT REPEAT 242..266
FT /note="LRR 9"
FT REPEAT 268..287
FT /note="LRR 10"
FT REPEAT 288..310
FT /note="LRR 11"
FT REPEAT 311..334
FT /note="LRR 12"
FT REPEAT 336..356
FT /note="LRR 13"
FT REPEAT 398..421
FT /note="LRR 14"
FT REPEAT 424..447
FT /note="LRR 15"
FT REPEAT 449..470
FT /note="LRR 16"
FT REPEAT 471..494
FT /note="LRR 17"
FT REPEAT 496..517
FT /note="LRR 18"
FT REPEAT 519..540
FT /note="LRR 19"
FT REPEAT 541..564
FT /note="LRR 20"
FT REPEAT 566..587
FT /note="LRR 21"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 71
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H9A6"
FT CONFLICT 4..5
FT /note="HM -> QL (in Ref. 1; BAC28900/BAE37277)"
FT /evidence="ECO:0000305"
FT CONFLICT 5
FT /note="M -> L (in Ref. 1; BAB27802)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 602 AA; 68076 MW; 52BB464BF82F29F6 CRC64;
MSRHMRAPRF DPRAGFHAEG KDRGPSVPQG LLKAARSSGQ LNLAGRNLGE VPQCVWRINV
DIPEEANQNL SFSSTERWWD QTDLTKLIIS SNKLQSLSDD LRLLPALTVL DIHDNQLTSL
PSAIRELDNL QKLNVSHNKL KILPEEITSL KNLRTLHLQH NELTCIPEGF EHLSCLEDLD
LSSNRLATVP ADFALLSSLL RLNLSSNQLK NLPAEISRMK RLKHLDCDAN LLETVPPDVG
SMESLELLYL RRNKLRVLPE FPSCRQLKEL HLAENQIEKL GAEHLQHLQA ILVLDLRGNK
LRSVPEEMAL LQSLERLDLS NNDISSLPCS LGNLHLKFLA LEGNPLRTIR REIIAKGTQE
VLKYLRSKIK DDRTNQNDSV PETAMTLPSE ARVNIHAIAT LKLLDYSDKQ ATLIPDDLFD
ATKTTLITSI NFSKNQLCEI PQRIVELKEM VLDINLSFNK LSFISHELCL LQKLTFLDLR
NNFLSSLPEE MSSLTKLQTI NLSFNRFKVF PEVLYRISTL EAVLISNNQV GSVDPQKMKL
MENLNTLDLQ NNDLLQIPPE LGNCVQLRTL LLDGNPFRVP RAAILMKGTA AVLEYLRDRI
PA
