ID   LRC41_BOVIN             Reviewed;         814 AA.
AC   Q29RR1;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Leucine-rich repeat-containing protein 41;
GN   Name=LRRC41;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Part of a E3 ubiquitin ligase complex with elongin BC complex
CC       (ELOB and ELOC), RBX1 and CUL5. {ECO:0000250}.
CC   -!- DOMAIN: The elongin BC complex binding domain is also known as BC-box
CC       with the consensus [APST]-L-x(3)-C-x(3)-[AILV]. {ECO:0000250}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-23 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; BC114065; AAI14066.1; -; mRNA.
DR   RefSeq; NP_001039338.1; NM_001045873.1.
DR   AlphaFoldDB; Q29RR1; -.
DR   SMR; Q29RR1; -.
DR   STRING; 9913.ENSBTAP00000040694; -.
DR   PaxDb; Q29RR1; -.
DR   PRIDE; Q29RR1; -.
DR   GeneID; 337889; -.
DR   KEGG; bta:337889; -.
DR   CTD; 10489; -.
DR   eggNOG; ENOG502R5T0; Eukaryota.
DR   InParanoid; Q29RR1; -.
DR   OrthoDB; 322569at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR026137; Leu_rpt_41.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR15354; PTHR15354; 1.
PE   2: Evidence at transcript level;
KW   Leucine-rich repeat; Phosphoprotein; Reference proteome; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..814
FT                   /note="Leucine-rich repeat-containing protein 41"
FT                   /id="PRO_0000292657"
FT   REPEAT          489..509
FT                   /note="LRR 1"
FT   REPEAT          520..532
FT                   /note="LRR 2"
FT   REPEAT          533..557
FT                   /note="LRR 3"
FT   REPEAT          615..637
FT                   /note="LRR 4"
FT   REPEAT          638..661
FT                   /note="LRR 5"
FT   REPEAT          703..730
FT                   /note="LRR 6"
FT   REPEAT          733..754
FT                   /note="LRR 7"
FT   REGION          45..54
FT                   /note="Interaction with Elongin BC complex"
FT                   /evidence="ECO:0000250"
FT   REGION          265..408
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        319..335
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        358..382
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         155
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15345"
FT   MOD_RES         276
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15345"
FT   MOD_RES         326
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15345"
FT   MOD_RES         327
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15345"
FT   MOD_RES         375
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15345"
SQ   SEQUENCE   814 AA;  88677 MW;  60608574DFB79A03 CRC64;
     MAAPEAWRAR SCWFCEVAAA TTMEATSREA APAKSSASGP SAPPALFELC GRAVSAHMGV
     LESGVWALPG PILQSILPLL NIYYLERIEE TALKKGLSTQ AIWRRLWDEL MKTRPSSLES
     VTCWRAKFME AFFSHVLRGT IDVSSDRRLC DQRFSPLLHS SRHVRQLTIC NMLQGATELV
     AEPNRRVLET LASSLHTLKF RHLLFSDVAA QQSLRQLLHQ LIHHGAVSQV SLYSWPVPES
     ALFILILTMS AGFWQPGPGG PPCRLCGEAS RGRAPSRDEG SLLLGSRRPR RDAAERCAAA
     LMASRRKSEA KQTARAAPAT RVTRRSTQES LTAGGTDSKR EPLPPATSHE APGTKRPPSA
     PATTSSASAS SSTSSSKRAP ASSAPQPKPL KRFKRAAGKK GARTRQGCGA ESEDLYDFVF
     IVAGEKEDGE EMEIGEVACG ALDGSDPSCL GLPALEASQR FRSISTLELF TVPLSTEAAL
     TLCHLLSSWV SLESLTLSYN GLGSNIFRLL DSLRALSVQA GCRLRALHLS DLFSPLPILE
     LTRAIVRALP LLRVLSIRVD HPSQRDNPAV PGNAGPPSNV IGDEEIPENC LEQLEMGFPR
     GAQPAPLLCS VLKASGSLQQ LSLDSATFAS PQDFGLVLQT LKEYNLTLKR LSFHDMNLAD
     CQSEVLFLLQ NLTLQEITFS FCRLFEKRPA QFLPEMVAAM KGNSTLKGLR LPGNRLGNAG
     LLALADVFSE DSSSSLCQLD ISSNCIKPDG LLEFAKRLER WGRGAFGHLR LFQNWLDQDA
     VTAREAIRRL RATCHVVSDS WDSSQAFADY VSTM